The E3 ubiquitin ligase HUWE1 acts through the N‐Myc‐DLL1‐NOTCH1 signaling axis to suppress glioblastoma progression
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DOI: 10.1002/cac2.12334
Abstract: Elucidation of the post‐transcriptional modification has led to novel strategies to treat intractable tumors, especially glioblastoma (GBM). The ubiquitin‐proteasome system (UPS) mediates a reversible, stringent and stepwise post‐translational modification which is closely associated with malignant… read more here.
Keywords: myc dll1; dll1 notch1; ubiquitin ligase; ligase huwe1 ... See more keywords
The giant E3 ligase HUWE1 is linked to tumorigenesis, spermatogenesis, intellectual disability, and inflammatory diseases
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DOI: 10.3389/fcimb.2022.905906
Abstract: E3 ubiquitin ligases determine the substrate specificity and catalyze the ubiquitination of lysine residues. HUWE1 is a catalytic HECT domain-containing giant E3 ligase that contains a substrate-binding ring structure, and mediates the ubiquitination of more… read more here.
Keywords: giant ligase; linked tumorigenesis; ligase huwe1; huwe1 ... See more keywords
Meta-analysis of gene expression alterations and clinical significance of the HECT domain-containing ubiquitin ligase HUWE1 in cancer
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DOI: 10.3892/ol.2019.10579
Abstract: E3 ubiquitin-protein ligase (HUWE1) has previously been identified as a HECT domain-containing ubiquitin ligase (E3) that is involved in several signaling pathways, transcriptional regulation, neural differentiation, DNA damage responses and apoptosis. However, the function of… read more here.
Keywords: hect domain; huwe1; ligase huwe1; expression ... See more keywords