Building ubiquitination machineries: E3 ligase multi-subunit assembly and substrate targeting by PROTACs and molecular glues.
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DOI: 10.1016/j.sbi.2020.10.009
Abstract: E3 ubiquitin ligase machineries are emerging as attractive therapeutic targets because they confer specificity to substrate ubiquitination and can be hijacked for targeted protein degradation. In this review, we bring to focus our current structural… read more here.
Keywords: machineries ligase; ligase multi; ubiquitination machineries; multi subunit ... See more keywords