RANKL coordinates multiple osteoclastogenic pathways by regulating expression of ubiquitin ligase RNF146
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DOI: 10.1172/jci90527
Abstract: Bone undergoes continuous remodeling due to balanced bone formation and resorption mediated by osteoblasts and osteoclasts, respectively. Osteoclasts arise from the macrophage lineage, and their differentiation is dependent on RANKL, a member of the TNF… read more here.
Keywords: rnf146; ubiquitin ligase; expression; ligase rnf146 ... See more keywords