Targeting SCF E3 Ligases for Cancer Therapies.
Sign Up to like & getrecommendations! Published in 2020 at "Advances in experimental medicine and biology"
DOI: 10.1007/978-981-15-1025-0_9
Abstract: SKP1-cullin-1-F-box-protein (SCF) E3 ubiquitin ligase complex is responsible for the degradation of proteins in a strictly regulated manner, through which it exerts pivotal roles in regulating various key cellular processes including cell cycle and division,… read more here.
Keywords: scf ligases; biology; cancer; ligases cancer ... See more keywords
E3 ubiquitin ligases in cancer and implications for therapies
Sign Up to like & getrecommendations! Published in 2017 at "Cancer and Metastasis Reviews"
DOI: 10.1007/s10555-017-9703-z
Abstract: E3 ligases are a class of enzymes that can transfer ubiquitin to substrates for their degradation, which are of importance in cellular homeostasis. Since many oncogenic or tumor-suppressive proteins are reported to be regulated by… read more here.
Keywords: cancer implications; ubiquitin ligases; implications therapies; cancer ... See more keywords
Ubiquitin Ligases in Cancer Immunotherapy - Balancing Antitumor and Autoimmunity.
Sign Up to like & getrecommendations! Published in 2019 at "Trends in molecular medicine"
DOI: 10.1016/j.molmed.2019.02.002
Abstract: Considerable progress has been made in understanding the contribution of E3 ubiquitin ligases to health and disease, including the pathogenesis of immunological disorders. Ubiquitin ligases exert exquisite spatial and temporal control over protein stability and… read more here.
Keywords: immunotherapy balancing; ubiquitin ligases; cancer immunotherapy; autoimmunity ... See more keywords
HECT-Type E3Â Ubiquitin Ligases in Cancer.
Sign Up to like & getrecommendations! Published in 2019 at "Trends in biochemical sciences"
DOI: 10.1016/j.tibs.2019.08.004
Abstract: Ubiquitination, a post-translational modification that involves a covalent attachment of ubiquitin to a protein substrate, is essential for cellular homeostatic maintenance. At the end of a three-enzyme cascade, E3 ubiquitin ligases (E3s) recruit substrates and… read more here.
Keywords: ligases cancer; type ubiquitin; hect type; ubiquitin ligases ... See more keywords
Cancer-Associated Dysregulation of Sumo Regulators: Proteases and Ligases
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DOI: 10.3390/ijms23148012
Abstract: SUMOylation is a post-translational modification that has emerged in recent decades as a mechanism involved in controlling diverse physiological processes and that is essential in vertebrates. The SUMO pathway is regulated by several enzymes, proteases… read more here.
Keywords: ligases cancer; dysregulation sumo; proteases ligases; cancer ... See more keywords