E3 Ligases Meet Their Match: Fragment-Based Approaches to Discover New E3 Ligands and to Unravel E3 Biology
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DOI: 10.1021/acs.jmedchem.2c01882
Abstract: Ubiquitination is a key post-translational modification of proteins, affecting the regulation of multiple cellular processes. Cells are equipped with over 600 ubiquitin orchestrators, called E3 ubiquitin ligases, responsible for directing the covalent attachment of ubiquitin… read more here.
Keywords: fragment based; discover new; new ligands; ligases meet ... See more keywords