Improved Metal-Free Approach for the Synthesis of Protected Thiol Containing Thymidine Nucleoside Phosphoramidite and Its Application for the Synthesis of Ligatable Oligonucleotide Conjugates
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DOI: 10.3390/pharmaceutics15010248
Abstract: Oligonucleotide conjugates are versatile scaffolds that can be applied in DNA-based screening platforms and ligand display or as therapeutics. Several different chemical approaches are available for functionalizing oligonucleotides, which are often carried out on the… read more here.
Keywords: application; ligatable oligonucleotide; synthesis; nucleoside phosphoramidite ... See more keywords