Longitudinal Associations of Blood Phosphorylated Tau181 and Neurofilament Light Chain With Neurodegeneration in Alzheimer Disease
Sign Up to like & getrecommendations! Published in 2021 at "JAMA Neurology"
DOI: 10.1001/jamaneurol.2020.4986
Abstract: Key Points Question What is the potential of blood-based biomarkers for predicting and monitoring the progression of Alzheimer disease neurodegeneration? Findings In this cohort study that included 1113 participants from the multicentric Alzheimer’s Disease Neuroimaging… read more here.
Keywords: neurofilament light; alzheimer disease; disease; neurodegeneration ... See more keywords
Challenges and Opportunities for the Promising Biomarker Blood Neurofilament Light Chain.
Sign Up to like & getrecommendations! Published in 2023 at "JAMA neurology"
DOI: 10.1001/jamaneurol.2023.0394
Abstract: This Viewpoint describes the benefits and limitations of using neurofilament light chain (NfL) as a marker of real-time disease activity and treatment response in multiple sclerosis. read more here.
Keywords: neurofilament light; challenges opportunities; opportunities promising; light chain ... See more keywords
Assessment of Pretreatment and Posttreatment Evolution of Neurofilament Light Chain Levels in Patients Who Develop Immune Effector Cell–Associated Neurotoxicity Syndrome
Sign Up to like & getrecommendations! Published in 2022 at "JAMA Oncology"
DOI: 10.1001/jamaoncol.2022.3738
Abstract: This cross-sectional study quantifies serial neurofilament light chain levels in patients undergoing cellular therapy. read more here.
Keywords: neurofilament light; light chain; chain levels; levels patients ... See more keywords
Comparison of SimoaTM and EllaTM to assess serum neurofilament‐light chain in multiple sclerosis
Sign Up to like & getrecommendations! Published in 2021 at "Annals of Clinical and Translational Neurology"
DOI: 10.1002/acn3.51355
Abstract: We compared SimoaTM and EllaTM immunoassays to assess serum neurofilament‐light chain levels in 203 multiple sclerosis patients from the OFSEP HD study. There was a strong correlation (ρ = 0.86, p < 0.0001) between both… read more here.
Keywords: serum neurofilament; neurofilament light; multiple sclerosis; light chain ... See more keywords
Neurofilament light chain and retinal layers' determinants and association: A population‐based study
Sign Up to like & getrecommendations! Published in 2022 at "Annals of Clinical and Translational Neurology"
DOI: 10.1002/acn3.51522
Abstract: Both retinal atrophy measured through optical coherence tomography and plasma neurofilament light chain (NfL) levels are markers of neurodegeneration, but their relationship is unknown. Therefore, we assessed their determinants and association in 4369 participants of… read more here.
Keywords: neurofilament light; retinal atrophy; determinants association; population based ... See more keywords
Development of an age‐adjusted model for blood neurofilament light chain
Sign Up to like & getrecommendations! Published in 2022 at "Annals of Clinical and Translational Neurology"
DOI: 10.1002/acn3.51524
Abstract: To develop an age‐adjustment model for neurofilament light chain (NfL), an emerging injury marker in patients with a range of neurologic conditions including multiple sclerosis (MS). read more here.
Keywords: neurofilament light; light chain; development age;
Decreased neurofilament light chain levels in estriol‐treated multiple sclerosis
Sign Up to like & getrecommendations! Published in 2022 at "Annals of Clinical and Translational Neurology"
DOI: 10.1002/acn3.51622
Abstract: Estrogens have neuroprotective actions depending on estrogen type, dose, and timing in both preclinical models and in women during health and disease. Serum neurofilament light chain is a putative biomarker of neurodegeneration in multiple sclerosis,… read more here.
Keywords: neurofilament light; multiple sclerosis; light chain;
Neurofilament light chain levels predict encephalopathy and outcome in community‐acquired pneumonia
Sign Up to like & getrecommendations! Published in 2022 at "Annals of Clinical and Translational Neurology"
DOI: 10.1002/acn3.51711
Abstract: Serum neurofilament light chain (sNfL) is a biomarker for neuroaxonal damage and has been found to be elevated in several neurological diseases with neuronal destruction. New onset of confusion is a hallmark of severity in… read more here.
Keywords: neurofilament light; light chain; acquired pneumonia; community acquired ... See more keywords
White matter hyperintensity, neurofilament light chain, and cognitive decline
Sign Up to like & getrecommendations! Published in 2022 at "Annals of Clinical and Translational Neurology"
DOI: 10.1002/acn3.51720
Abstract: We aimed to determine whether combining white matter hyperintensity (WMH) with neurofilament light chain (NfL) could provide additional information for cognition in older adults. read more here.
Keywords: white matter; neurofilament light; matter hyperintensity; light chain ... See more keywords
Stability and uniqueness of clonal immunoglobulin CDR3 sequences for MRD tracking in multiple myeloma
Sign Up to like & getrecommendations! Published in 2019 at "American Journal of Hematology"
DOI: 10.1002/ajh.25641
Abstract: Minimal residual disease (MRD) tracking, by next generation sequencing of immunoglobulin sequences, is moving towards clinical implementation in multiple myeloma. However, there is only sparse information available to address whether clonal sequences remain stable for… read more here.
Keywords: cdr3 sequences; mrd tracking; multiple myeloma; light chain ... See more keywords
Impact of minimal residual negativity using next generation flow cytometry on outcomes in light chain amyloidosis
Sign Up to like & getrecommendations! Published in 2020 at "American Journal of Hematology"
DOI: 10.1002/ajh.25746
Abstract: We evaluated bone marrow minimal residual disease (MRD) negativity in 44 patients with light chain (AL) amyloidosis using next generation flow cytometry (sensitivity ≥1 × 10−5; median events analyzed: 8.7 million, range: 4.8 to 9.7 million). All… read more here.
Keywords: minimal residual; mrd; response; mrd negative ... See more keywords