Understanding Mesangial Pathobiology in AL-Amyloidosis and Monoclonal Ig Light Chain Deposition Disease
Sign Up to like & getrecommendations! Published in 2020 at "Kidney International Reports"
DOI: 10.1016/j.ekir.2020.07.013
Abstract: Patients with plasma cell dyscrasias produce free abnormal monoclonal Ig light chains that circulate in the blood stream. Some of them, termed glomerulopathic light chains, interact with the mesangial cells and trigger, in a manner… read more here.
Keywords: monoclonal light; disease; light; light chains ... See more keywords
The Proximal Tubule Toxicity of Immunoglobulin Light Chains
Sign Up to like & getrecommendations! Published in 2021 at "Kidney International Reports"
DOI: 10.1016/j.ekir.2021.02.026
Abstract: Plasma and B cells dyscrasias that overproduce monoclonal immunoglobulin free light chains (FLCs) affect the kidney frequently in various ways. The hematologic dyscrasia responsible for the production of FLCs may or may not meet the… read more here.
Keywords: immunoglobulin; proximal tubule; light chains; tubule toxicity ... See more keywords
Individual B cells transcribe multiple rearranged immunoglobulin light chains in teleost fish
Sign Up to like & getrecommendations! Published in 2021 at "iScience"
DOI: 10.1016/j.isci.2021.102615
Abstract: Summary B cells express a unique antibody protein which comprises two pairs of immunoglobulin (Ig) heavy (H) and light (L) chains. In addition to an invariable constant (C) region, IgH and IgL chains encompass a… read more here.
Keywords: cells transcribe; light; individual cells; light chains ... See more keywords
Kappa free light chains could predict early disease course in multiple sclerosis.
Sign Up to like & getrecommendations! Published in 2019 at "Multiple sclerosis and related disorders"
DOI: 10.1016/j.msard.2019.02.001
Abstract: BACKGROUND Cerebrospinal fluid (CSF) kappa free light chains (KFLC) have been suggested as quantitative alternative to oligoclonal bands (OB) in multiple sclerosis (MS) diagnosis. Despite OB have been associated to poor disease prognosis, little is… read more here.
Keywords: sclerosis; free light; multiple sclerosis; light chains ... See more keywords
Analytical and clinical concordance of free light chain assay
Sign Up to like & getrecommendations! Published in 2019 at "Practical Laboratory Medicine"
DOI: 10.1016/j.plabm.2018.e00112
Abstract: The analysis of serum for the presence of free light chains has become an important adjunct to testing by serum protein electrophoresis (SPE) and immunofixation electrophoresis (IFE) [1]. The first commercial free light chain assays… read more here.
Keywords: free light; concordance; light; light chains ... See more keywords
Unfolding and Aggregation Pathways of Variable Domains from Immunoglobulin Light Chains.
Sign Up to like & getrecommendations! Published in 2023 at "Biochemistry"
DOI: 10.1021/acs.biochem.2c00704
Abstract: Light chain amyloidosis is the most common form of systemic amyloidosis. This disease is caused by the formation and deposition of amyloid fibers made from immunoglobulin light chains. Environmental conditions such as pH and temperature… read more here.
Keywords: unfolding aggregation; aggregation; aggregation pathways; light chains ... See more keywords
Antibodies utilizing VL6-57 light chains target a convergent cryptic epitope on SARS-CoV-2 spike protein and potentially drive the genesis of Omicron variants
Sign Up to like & getrecommendations! Published in 2024 at "Nature Communications"
DOI: 10.1038/s41467-024-51770-3
Abstract: Continued evolution of SARS-CoV-2 generates variants to challenge antibody immunity established by infection and vaccination. A connection between population immunity and genesis of virus variants has long been suggested but its molecular basis remains poorly… read more here.
Keywords: sars cov; light chains; omicron variants; vl6 light ... See more keywords
The roles of grouper clathrin light chains in regulating the infection of a novel marine DNA virus, Singapore grouper iridovirus
Sign Up to like & getrecommendations! Published in 2019 at "Scientific Reports"
DOI: 10.1038/s41598-019-51725-5
Abstract: Clathrins, composed of clathrin heavy chains (CHCs) and clathrin light chains (CLCs), are usually hijacked by viruses for infection. However, the role of CLCs, especially in regulating fish virus infection, remains poorly understood. Here, two… read more here.
Keywords: clathrin light; sgiv; infection; light chains ... See more keywords
Exploring the sequence features determining amyloidosis in human antibody light chains
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DOI: 10.1038/s41598-021-93019-9
Abstract: The light chain (AL) amyloidosis is caused by the aggregation of light chain of antibodies into amyloid fibrils. There are plenty of computational resources available for the prediction of short aggregation-prone regions within proteins. However,… read more here.
Keywords: aggregation; antibody light; antibody; light ... See more keywords
Structural role of essential light chains in the apicomplexan glideosome
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DOI: 10.1038/s42003-020-01283-8
Abstract: Gliding, a type of motility based on an actin-myosin motor, is specific to apicomplexan parasites. Myosin A binds two light chains which further interact with glideosome associated proteins and assemble into the glideosome. The role… read more here.
Keywords: myoa; light; essential light; role ... See more keywords
Landscape of B Cell Receptor Repertoires in COVID-19 Patients Revealed Through CDR3 Sequencing of Immunoglobulin Heavy and Light Chains
Sign Up to like & getrecommendations! Published in 2022 at "Immunological Investigations"
DOI: 10.1080/08820139.2022.2092407
Abstract: ABSTRACT The outbreak and persistence of coronavirus disease 2019 (COVID-19) threaten human health. B cells play a vital role in fighting the infections caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Despite many studies… read more here.
Keywords: covid patients; immunoglobulin heavy; light chains; cdr3 sequencing ... See more keywords