Germinal Center B Cells Replace Their Antigen Receptors in Dark Zones and Fail Light Zone Entry when Immunoglobulin Gene Mutations are Damaging
Sign Up to like & getrecommendations! Published in 2018 at "Immunity"
DOI: 10.1016/j.immuni.2018.08.025
Abstract: SUMMARY Adaptive immunity involves the development of bespoke antibodies in germinal centers (GCs) through immunoglobulin somatic hypermutation (SHM) in GC dark zones (DZs) and clonal selection in light zones (LZs). Accurate selection requires that cells… read more here.
Keywords: germinal center; dark zones; center cells; cells replace ... See more keywords
A Spatially Resolved Dark- versus Light-Zone Microenvironment Signature Subdivides Germinal Center-Related Aggressive B Cell Lymphomas
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DOI: 10.1016/j.isci.2020.101562
Abstract: Summary We applied digital spatial profiling for 87 immune and stromal genes to lymph node germinal center (GC) dark- and light-zone (DZ/LZ) regions of interest to obtain a differential signature of these two distinct microenvironments.… read more here.
Keywords: germinal center; cell lymphomas; signature; spatially resolved ... See more keywords
Positive Selection in the Light Zone of Germinal Centers
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DOI: 10.3389/fimmu.2021.661678
Abstract: Germinal centers (GCs) are essential sites for the production of high-affinity antibody secreting plasma cells (PCs) and memory-B cells (MBCs), which form the framework of vaccination. Affinity maturation and permissive selection in GCs are key… read more here.
Keywords: positive selection; selection; selection light; germinal centers ... See more keywords