Ligustrazine Protects Homocysteine-Induced Apoptosis in Human Umbilical Vein Endothelial Cells by Modulating Mitochondrial Dysfunction
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cardiovascular Translational Research"
DOI: 10.1007/s12265-019-09900-6
Abstract: Ligustrazine is one of the alkaloid compounds isolated from the traditional Chinese herb, which shows protective effects on cardiovascular disorders. High homocysteine (Hcy) level can predict cardiovascular-related events including death. In this study, we used… read more here.
Keywords: apoptosis; dysfunction; human umbilical; umbilical vein ... See more keywords
Ligustrazine modulates renal cysteine biosynthesis in rats exposed to cadmium.
Sign Up to like & getrecommendations! Published in 2017 at "Environmental toxicology and pharmacology"
DOI: 10.1016/j.etap.2017.07.003
Abstract: The objective of this study was to determine the effect of ligustrazine (TMP) on cadmium (Cd)-induced nephrotoxicity and its relevant mechanism. TMP (50mg/kg) was injected intraperitoneally (i.p.) into rats 1h prior to CdCl2 exposure (at… read more here.
Keywords: biosynthesis; rats exposed; cadmium; ligustrazine ... See more keywords
Elucidating the Novel Mechanism of Ligustrazine in Preventing Postoperative Peritoneal Adhesion Formation
Sign Up to like & getrecommendations! Published in 2022 at "Oxidative Medicine and Cellular Longevity"
DOI: 10.1155/2022/9226022
Abstract: Postoperative peritoneal adhesion (PPA) is a major clinical complication after open surgery or laparoscopic procedure. Ligustrazine is the active ingredient extracted from the natural herb Ligusticum chuanxiong Hort, which has promising antiadhesion properties. This study… read more here.
Keywords: postoperative peritoneal; ligustrazine; peritoneal adhesion; ppa ... See more keywords
Induction of ligustrazine apoptosis of A549 cells through activation of death receptor pathway
Sign Up to like & getrecommendations! Published in 2022 at "Translational Cancer Research"
DOI: 10.21037/tcr-22-455
Abstract: Background The aim of this study was to evaluate the effect of ligustrazine on the apoptosis of A549 cells and clarify the mechanism of ligustrazine-induced apoptosis. Methods Ligustrazine was prepared with medium according to the… read more here.
Keywords: death receptor; apoptosis; a549 cells; ligustrazine ... See more keywords