Impact of Philadelphia chromosome‐like alterations on efficacy and safety of blinatumomab in adults with relapsed/refractory acute lymphoblastic leukemia: A post hoc analysis from the phase 3 TOWER study
Sign Up to like & getrecommendations! Published in 2021 at "American Journal of Hematology"
DOI: 10.1002/ajh.26281
Abstract: Philadelphia chromosome (Ph)-like acute lymphoblastic leukemia (ALL) is a high-risk subgroup of precursor B-cell (BCP) ALL. In the phase 3 TOWER trial (NCT02013167), blinatumomab demonstrated superior overall survival (OS) than standard of care chemotherapy (SOC)… read more here.
Keywords: efficacy safety; safety blinatumomab; blinatumomab; patients like ... See more keywords
Terpenoid‐rich Elettaria cardamomum extract prevents Alzheimer‐like alterations induced in diabetic rats via inhibition of GSK3&bgr; activity, oxidative stress and pro‐inflammatory cytokines
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DOI: 10.1016/j.cyto.2018.10.017
Abstract: Purpose: Recent studies suggested that the non‐familiar form of Alzheimer's disease (AD) could be consequence of metabolic syndrome and neuroinflammation. Elettaria cardamomum extract (EC) has exhibited antidiabetic, antioxidant and anti‐inflammatory properties. This research was conducted… read more here.
Keywords: t2dm rats; bgr; elettaria cardamomum; cardamomum extract ... See more keywords
Early Blockade of CB1 Receptors Ameliorates Schizophrenia-like Alterations in the Neurodevelopmental MAM Model of Schizophrenia
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DOI: 10.3390/biom12010108
Abstract: In agreement with the neurodevelopmental hypothesis of schizophrenia, prenatal exposure of Sprague-Dawley rats to the antimitotic agent methylazoxymethanol acetate (MAM) at gestational day 17 produces long-lasting behavioral alterations such as social withdrawal and cognitive impairment… read more here.
Keywords: like alterations; blockade cb1; cb1 receptors; early blockade ... See more keywords