TCR-like antibody drug conjugates mediate killing of tumor cells with low peptide/HLA targets
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DOI: 10.1080/19420862.2017.1302630
Abstract: ABSTRACT The currently marketed antibody-drug conjugates (ADC) destabilize microtubule assembly in cancer cells and initiate apoptosis in patients. However, few tumor antigens (TA) are expressed at high densities on cancer lesions, potentially minimizing the therapeutic… read more here.
Keywords: drug conjugates; tcr like; like antibody; antibody drug ... See more keywords