Gasotransmitter‐Nanodonor for Spatial Regulation of Anxiety‐Like Behavior and Bone Metastasis
Sign Up to like & getrecommendations! Published in 2025 at "Advanced Materials"
DOI: 10.1002/adma.202416481
Abstract: Anxiety is highly prevalent among cancer patients, significantly impacting their prognosis. Current cancer therapies typically lack anxiolytic properties and may even exacerbate anxiety. Here, a gasotransmitter‐nanodonors (GND) system is presented that exerts dual anxiolytic and… read more here.
Keywords: anxiety like; gasotransmitter nanodonor; like behavior; tumor ... See more keywords
Distinct Thalamo‐Subcortical Circuits Underlie Painful Behavior and Depression‐Like Behavior Following Nerve Injury
Sign Up to like & getrecommendations! Published in 2024 at "Advanced Science"
DOI: 10.1002/advs.202401855
Abstract: Clinically, chronic pain and depression often coexist in multiple diseases and reciprocally reinforce each other, which greatly escalates the difficulty of treatment. The neural circuit mechanism underlying the chronic pain/depression comorbidity remains unclear. The present… read more here.
Keywords: like behavior; depression; distinct thalamo; painful behavior ... See more keywords
Evaluation of p21 expression and related autism‐like behavior in Bisphenol‐A exposed offspring of Wistar albino rats
Sign Up to like & getrecommendations! Published in 2022 at "Birth Defects Research"
DOI: 10.1002/bdr2.2022
Abstract: Bisphenol A (BPA), an endocrine disruptor, may be involved in the etiology of autism spectrum disorders (ASD); however, the mechanism of neuronal and astrocytic damage remains ambiguous. A possible role of altered expression of p21… read more here.
Keywords: autism; evaluation p21; expression related; like behavior ... See more keywords
A behavioral and molecular study; ameliorated anxiety‐like behavior and cognitive dysfunction in a rat model of chronic unpredictable stress treated with oregano extract
Sign Up to like & getrecommendations! Published in 2022 at "Brain and Behavior"
DOI: 10.1002/brb3.2727
Abstract: Chronic stress is considered a severe risk factor leading to various disorders, including anxiety and cognitive decline. The present study aimed to investigate the effects of Origanum vulgare (oregano) extract on improving anxiety‐like behavior and… read more here.
Keywords: stress; anxiety like; oregano extract; chronic unpredictable ... See more keywords
Sensitization of depressive-like behavior is attenuated by disruption of prostaglandin synthesis days following brief early attachment-figure isolation.
Sign Up to like & getrecommendations! Published in 2022 at "Developmental psychobiology"
DOI: 10.1002/dev.22237
Abstract: Childhood psychological trauma appears to sensitize stress-related neuroinflammatory systems to increase later vulnerability for depression and other stress-related mental disorders. Isolation of guinea pig pups from the maternal attachment figure for 3 h in threatening surroundings… read more here.
Keywords: attachment figure; like behavior; isolation; sensitization ... See more keywords
Environmental enrichment decreases anxiety‐like behavior in zebrafish larvae
Sign Up to like & getrecommendations! Published in 2022 at "Developmental Psychobiology"
DOI: 10.1002/dev.22255
Abstract: Abstract The development of anxiety disorders is often linked to individuals’ negative experience. In many animals, development of anxiety‐like behavior is modeled by manipulating individuals’ exposure to environmental enrichment. We investigated whether environmental enrichment during… read more here.
Keywords: anxiety like; environmental enrichment; larvae; like behavior ... See more keywords
Limited bedding nesting paradigm alters maternal behavior and pup's early developmental milestones but did not induce anxiety- or depressive-like behavior in two different inbred mice.
Sign Up to like & getrecommendations! Published in 2022 at "Developmental psychobiology"
DOI: 10.1002/dev.22357
Abstract: Animal models are crucial to understanding the mechanisms underlying the deleterious consequences of early-life stress. Here, we aimed to examine the effect of the limited bedding nesting (LBN) paradigm on early life development milestones and… read more here.
Keywords: limited bedding; maternal behavior; behavior; mice ... See more keywords
Protein kinase C beta relieves autism‐like behavior in EN2 knockout mice via upregulation of the FTO/PGC‐1α/UCP1 axis
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Biochemical and Molecular Toxicology"
DOI: 10.1002/jbt.23236
Abstract: Increasing evidence suggests that disruption of neuron activity contributes to the autistic phenotype. Thus, we aimed in this study to explore the role of protein kinase C beta (PKCβ) in the regulation of neuron activity… read more here.
Keywords: fto; protein; like behavior; autism like ... See more keywords
Maternal prenatal stress and depression‐like behavior associated with hippocampal and cortical neuroinflammation in the offspring: An experimental study
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Developmental Neuroscience"
DOI: 10.1002/jdn.10176
Abstract: Prenatal stress can negatively impact neonatal health, growth, and bonding with the mother. However, molecular basis of these modifications is not completely understood. The aim of this experimental study was to test the hypothesis that… read more here.
Keywords: stress; neuroinflammation; depression; prenatal stress ... See more keywords
Sex and estrous‐phase dependent alterations in depression‐like behavior following mild traumatic brain injury in adolescent rats
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Neuroscience Research"
DOI: 10.1002/jnr.24989
Abstract: Following mild traumatic brain injury (TBI), high school and collegiate‐aged females tend to report more emotional symptoms than males. Adolescent male and female rats (35 days old) were subjected to mild TBI and evaluated for… read more here.
Keywords: like behavior; phase; following mild; injury ... See more keywords
Sex-specific contribution of glucocorticoid receptor alpha isoforms to anxiety and depressive-like behavior in mice.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of neuroscience research"
DOI: 10.1002/jnr.25032
Abstract: Adolescent stress predisposes individuals to increased risk for anxiety and depression in adulthood. The stress response is mediated by the glucocorticoid receptor (GR) via regulation of GR-responsive genes involved in brain reaction to stress. Although… read more here.
Keywords: like behavior; glucocorticoid receptor; stress; anxiety depressive ... See more keywords