Intranasal Delivery of circATF7IP siRNA via Lipid Nanoparticles Alleviates LPS‐induced Depressive‐Like Behaviors
Sign Up to like & getrecommendations! Published in 2024 at "Advanced Healthcare Materials"
DOI: 10.1002/adhm.202402219
Abstract: Major depressive disorder (MDD) is a prevalent mental disorder that significantly impacts social and psychological function, but no effective medication is currently available. Circular RNAs (circRNAs) have been reported to participate in the pathogenesis of… read more here.
Keywords: like behaviors; delivery; depressive like; circatf7ip ... See more keywords
Propofol Alleviates Anxiety‐Like Behaviors Associated with Pain by Inhibiting the Hyperactivity of PVNCRH Neurons via GABAA Receptor β3 Subunits
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DOI: 10.1002/advs.202309059
Abstract: Pain, a comorbidity of anxiety disorders, causes substantial clinical, social, and economic burdens. Emerging evidence suggests that propofol, the most commonly used general anesthetic, may regulate psychological disorders; however, its role in pain‐associated anxiety is… read more here.
Keywords: anxiety like; like behaviors; pvncrh neurons; pain ... See more keywords
Melatonin Ameliorates Depressive‐Like Behaviors in Ovariectomized Mice by Improving Tryptophan Metabolism via Inhibition of Gut Microbe Alistipes Inops
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DOI: 10.1002/advs.202309473
Abstract: Melatonin (N‐acetyl‐5‐methoxytryptamine) is reported to improve mood disorders in perimenopausal women and gut microbiome composition is altered during menopausal period. The possible role of microbiome in the treatment effect of melatonin on menopausal depression remains… read more here.
Keywords: like behaviors; operated mice; alistipes inops; depressive like ... See more keywords
Lysosomal TFEB‐TRPML1 Axis in Astrocytes Modulates Depressive‐like Behaviors
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DOI: 10.1002/advs.202403389
Abstract: Lysosomes are important cellular structures for human health as centers for recycling, signaling, metabolism and stress adaptation. However, the potential role of lysosomes in stress‐related emotions has long been overlooked. Here, it is found that… read more here.
Keywords: lysosomal tfeb; like behaviors; tfeb trpml1; trpml1 axis ... See more keywords
Brain Specific RagA Overexpression Triggers Depressive‐Like Behaviors in Mice via Activating ADORA2A Signaling Pathway
Sign Up to like & getrecommendations! Published in 2024 at "Advanced Science"
DOI: 10.1002/advs.202404188
Abstract: Neuroinflammation hallmarks the pathology of depression although the etiological complexity has not yet been resolved. Previous studies demonstrate that bacterial lipopolysaccharide induces depressive‐like behaviors by activating RagA‐mTOR‐p70S6K signaling pathway. The current project aims to investigate… read more here.
Keywords: like behaviors; raga overexpression; depressive like; signaling pathway ... See more keywords
Impulsivity and compulsivity as parallel mediators of emotion dysregulation in eating‐related addictive‐like behaviors, alcohol use, and compulsive exercise
Sign Up to like & getrecommendations! Published in 2021 at "Brain and Behavior"
DOI: 10.1002/brb3.2458
Abstract: Transdiagnostically relevant psychological traits associated with psychiatric disorders are increasingly being researched, notably in substance use and addictive behaviors. We investigated whether emotion dysregulation mediated by impulsivity and/or compulsivity could explain variance in binge eating,… read more here.
Keywords: compulsive exercise; alcohol use; addictive like; like behaviors ... See more keywords
Inhibition of Connexin 36 attenuates HMGB1‐mediated depressive‐like behaviors induced by chronic unpredictable mild stress
Sign Up to like & getrecommendations! Published in 2022 at "Brain and Behavior"
DOI: 10.1002/brb3.2470
Abstract: High mobility group box 1 (HMGB1) released by neurons and microglia was demonstrated to be an important mediator in depressive‐like behaviors induced by chronic unpredictable mild stress (CUMS), which could lead to the imbalance of… read more here.
Keywords: like behaviors; chronic unpredictable; behaviors induced; induced chronic ... See more keywords
Prognosis of rapid onset functional tic‐like behaviors: Prospective follow‐up over 6 months
Sign Up to like & getrecommendations! Published in 2022 at "Brain and Behavior"
DOI: 10.1002/brb3.2606
Abstract: The prognosis of rapid onset functional tic‐like behaviors (FTLBs) is unknown. This prospective cohort study describes the course and treatment of rapid onset FTLBs in adolescents (n = 20) and adults (n = 9) previously… read more here.
Keywords: onset functional; like behaviors; tic like; rapid onset ... See more keywords
Tuina Alleviates Anxiety‐Like Behaviors Associated With Neuropathic Pain Through the Modulation of Synaptic Plasticity in the Anterior Cingulate Cortex
Sign Up to like & getrecommendations! Published in 2025 at "Brain and Behavior"
DOI: 10.1002/brb3.70965
Abstract: As the disease progresses, neuropathic pain (NP) is often accompanied by anxiety‐like behaviors, which are associated with plastic changes in the synaptic structure and function within the anterior cingulate cortex (ACC). Tuina is a traditional… read more here.
Keywords: anxiety like; like behaviors; anterior cingulate; neuropathic pain ... See more keywords
Sex and age differences in locomotor and anxiety-like behaviors in rats: From adolescence to adulthood.
Sign Up to like & getrecommendations! Published in 2020 at "Developmental psychobiology"
DOI: 10.1002/dev.22037
Abstract: Risk-taking behaviors are a primary contributor to elevated adolescent injury and mortality. Locomotor and anxiety-like behaviors in rodents have been used to examine risk-taking. Here, we examined risk-taking behavior (i.e., changes in locomotor and anxiety-like… read more here.
Keywords: anxiety; locomotor anxiety; adolescence; anxiety like ... See more keywords
Cuminaldehyde, a Hopeful Agent, Mitigates Autistic‐Like Behaviors, Combating Hippocampal Neuroinflammation in Maternal Separation Stress Model in Male Mice
Sign Up to like & getrecommendations! Published in 2025 at "Developmental Neurobiology"
DOI: 10.1002/dneu.23008
Abstract: Autism spectrum disorder (ASD) is a neurodevelopmental disorder that appears in the earliest ages of the lifespan. The causes of ASD remain anonymous, although immunological, genetic, biological, and psychosocial theories have been proposed. Stresses during… read more here.
Keywords: mice; like behaviors; autistic like; cuminaldehyde ... See more keywords