SALL4 ‐ KHDRBS3 network enhances stemness by modulating CD44 splicing in basal‐like breast cancer
Sign Up to like & getrecommendations! Published in 2018 at "Cancer Medicine"
DOI: 10.1002/cam4.1296
Abstract: Understanding the mechanism by which cancer cells enhance stemness facilitates cancer therapies. Here, we revealed that a stem cell transcription factor, SALL4, functions to enhance stemness in basal‐like breast cancer cells. We used shRNA‐mediated knockdown… read more here.
Keywords: stemness; like breast; breast cancer; cancer ... See more keywords
Impact of estrogen receptor α on the tamoxifen response and prognosis in luminal-A-like and luminal-B-like breast cancer
Sign Up to like & getrecommendations! Published in 2019 at "Clinical and Experimental Medicine"
DOI: 10.1007/s10238-019-00583-6
Abstract: The luminal-A-like and luminal-B-like breast cancer groups have distinct biological features that lead to differences in the treatment response and clinical outcome. The aim of this study was to examine the value of the distribution… read more here.
Keywords: response; like breast; luminal like; breast cancer ... See more keywords
Aurora B induces epithelial–mesenchymal transition by stabilizing Snail1 to promote basal-like breast cancer metastasis
Sign Up to like & getrecommendations! Published in 2020 at "Oncogene"
DOI: 10.1038/s41388-020-1165-z
Abstract: Aurora B is a serine/threonine kinase that has been implicated in regulating cell proliferation in distinct cancers, including breast cancer. Here we show that Aurora B expression is elevated in basal-like breast cancer (BLBC) compared… read more here.
Keywords: breast; like breast; breast cancer; metastasis ... See more keywords
Single-cell profiling defines the prognostic benefit of CD39high tissue resident memory CD8+ T cells in luminal-like breast cancer
Sign Up to like & getrecommendations! Published in 2021 at "Communications Biology"
DOI: 10.1038/s42003-021-02595-z
Abstract: Luminal-like breast cancer (BC) constitutes the majority of BC subtypes, but, differently from highly aggressive triple negative BC, is poorly infiltrated by the immune system. The quality of the immune infiltrate in luminal-like BCs has… read more here.
Keywords: single cell; breast; like breast; luminal like ... See more keywords
Hippo-TAZ signaling is the master regulator of the onset of triple-negative basal-like breast cancers
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2123134119
Abstract: Significance A universal oncogenic driver of basal-like breast cancer (BLBC) has resisted identification. We show that continuous transcriptional coactivator with PDZ-binding motif (TAZ) activation in precancerous murine luminal cells generates luminal cancers that later become… read more here.
Keywords: like breast; basal like; taz signaling; hippo taz ... See more keywords
Pentraxin-3 is a PI3K signaling target that promotes stem cell–like traits in basal-like breast cancers
Sign Up to like & getrecommendations! Published in 2017 at "Science Signaling"
DOI: 10.1126/scisignal.aah4674
Abstract: PI3K-stimulated induction of pentraxin-3 links innate immune signaling with the growth of basal-like breast cancer. Pentraxin-3 promotes growth of stem-like cancers The phosphoinositide 3-kinase (PI3K) pathway is activated in various cancers. Unfortunately, PI3K inhibitors have… read more here.
Keywords: pi3k; basal like; breast; like breast ... See more keywords
YAP and β-Catenin Cooperate to Drive Oncogenesis in Basal Breast Cancer
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DOI: 10.1158/0008-5472.can-20-2801
Abstract: These findings show that YAP cooperates with β-catenin in basal-like breast cancer to regulate CSCs and that targeting this interaction may be a novel CSC therapy for patients with basal-like breast cancer. Targeting cancer stem… read more here.
Keywords: breast; basal like; like breast; basal ... See more keywords
Network Analysis Identifies Regulators of Basal-Like Breast Cancer Reprogramming and Endocrine Therapy Vulnerability
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DOI: 10.1158/0008-5472.can-21-0621
Abstract: A network model enables investigation of mechanisms regulating the basal-to-luminal transition in breast cancer, identifying BCL11A and HDAC1/2 as optimal targets that can induce basal-like breast cancer reprogramming and endocrine therapy sensitivity. Basal-like breast cancer… read more here.
Keywords: basal like; like breast; cancer; breast cancer ... See more keywords
Abstract P5-07-09: Identification of miRNA biomarkers for early diagnosis of basal-like breast cancer
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DOI: 10.1158/1538-7445.sabcs17-p5-07-09
Abstract: The routine screening for breast cancer relies primarily on imaging techniques such as mammography and ultrasonography, but it is often not sensitive enough for early detection and requires complementary approaches. Recent studies suggest that microRNAs… read more here.
Keywords: biomarkers early; like breast; breast cancer; cancer ... See more keywords
Abstract A12: YAP and cancer stem cells in basal-like breast cancer
Sign Up to like & getrecommendations! Published in 2020 at "Molecular Cancer Research"
DOI: 10.1158/1557-3125.hippo19-a12
Abstract: Cancer stem cells (CSCs) are responsible for minimal residual disease tumor relapse. Appearing as the optimal target for therapy, these cells are very difficult to target due to their ability to resist proapoptotic stimuli. In… read more here.
Keywords: stem cells; cancer stem; like breast; cancer ... See more keywords
Identification of key genes unique to the luminal a and basal-like breast cancer subtypes via bioinformatic analysis
Sign Up to like & getrecommendations! Published in 2020 at "World Journal of Surgical Oncology"
DOI: 10.1186/s12957-020-02042-z
Abstract: Background Breast cancer subtypes are statistically associated with prognosis. The search for markers of breast tumor heterogeneity and the development of precision medicine for patients are the current focuses of the field. Methods We used… read more here.
Keywords: cancer; basal like; like breast; breast cancer ... See more keywords