Malformin C preferentially kills glioblastoma stem‐like cells via concerted induction of proteotoxic stress and autophagic flux blockade
Sign Up to like & getrecommendations! Published in 2024 at "Molecular Oncology"
DOI: 10.1002/1878-0261.13756
Abstract: Glioblastoma is a highly aggressive brain tumor for which there is no cure. The dire prognosis of this disease is largely attributable to a high level of heterogeneity, including the presence of a subpopulation of… read more here.
Keywords: malformin preferentially; like cells; malformin; autophagic flux ... See more keywords
MicroRNA‐Modified DNA Hexahedron‐Induced Hepatocyte‐Like Cells Integrating 3D Printed Scaffold for Acute Liver Failure Therapy
Sign Up to like & getrecommendations! Published in 2024 at "Advanced Functional Materials"
DOI: 10.1002/adfm.202402339
Abstract: Acute liver failure (ALF) involves extensive necrosis of liver cells and severe impairment of liver function. Hepatocyte transplantation holds promise for treating ALF by swiftly supporting liver functions and promoting liver regeneration. However, the scarcity… read more here.
Keywords: like cells; hepatocyte; hepatocyte like; acute liver ... See more keywords
SLPI⁺ AT2-Like Cells Orchestrate Lung Adenocarcinoma Invasion via Wnt Pathway Activation and Stromal Crosstalk in a Spatially Defined Margin Niche.
Sign Up to like & getrecommendations! Published in 2025 at "Advanced science"
DOI: 10.1002/advs.202516580
Abstract: The spatial organization of the tumor microenvironment (TME) profoundly influences cancer biology. However, the cell types and spatial distribution driving lung adenocarcinoma (LUAD) invasion remain poorly understood. By integrating spatially resolved transcriptomics with scRNA-seq data,… read more here.
Keywords: like cells; lung adenocarcinoma; slpi at2; tumor ... See more keywords
Hepatocyte‐like cells generated by direct reprogramming from murine somatic cells can repopulate decellularized livers
Sign Up to like & getrecommendations! Published in 2018 at "Biotechnology and Bioengineering"
DOI: 10.1002/bit.26784
Abstract: Direct reprogramming represents an easy technique to generate induced hepatocytes (iHeps) from somatic cells. However, current protocols are accompanied by several drawbacks as iHeps are heterogenous and lack fully mature phenotypes of primary hepatocytes. Here,… read more here.
Keywords: hepatocyte like; like cells; repopulate decellularized; direct reprogramming ... See more keywords
Knockdown of STAT3 targets a subpopulation of invasive melanoma stem‐like cells
Sign Up to like & getrecommendations! Published in 2019 at "Cell Biology International"
DOI: 10.1002/cbin.11134
Abstract: Transcription factor signal transducer and activator of transcription 3 (STAT3) is constitutively activated in many cancers, including melanomas. Active, phosphorylated STAT3 contributes to tumor growth and formation of the immunosuppressive tumor microenvironment. Recent evidence suggests… read more here.
Keywords: melanoma; melanoma cscs; like cells; stat3 ... See more keywords
Echinoderm Radial Glia‐Like Cells Express Vertebrate Glial Markers
Sign Up to like & getrecommendations! Published in 2025 at "Journal of Comparative Neurology"
DOI: 10.1002/cne.70096
Abstract: Radial glia‐like cells (RGLCs) are recognized as cells with morphological and molecular similarities to embryonic radial glia but present in the nervous system of adult organisms. They are well known for playing key roles in… read more here.
Keywords: vertebrate glial; like cells; echinoderm radial; markers echinoderm ... See more keywords
hiPSC‐Derived Astrocytes From Individuals With Schizophrenia Induce a Dystrophic Phenotype in Microglial‐Like Cells
Sign Up to like & getrecommendations! Published in 2025 at "Glia"
DOI: 10.1002/glia.70085
Abstract: Neuroinflammation, particularly astrocyte reactivity, is increasingly linked to schizophrenia (SCZ). Yet, the crosstalk between astrocytes and microglia in SCZ, especially under pro-inflammatory conditions, remains unclear. Here, we employed human induced-pluripotent stem cells to compare how… read more here.
Keywords: reactive scz; like cells; microglial like; scz astrocytes ... See more keywords
mTOR Signaling in X/A‐Like Cells Contributes to Lipid Homeostasis in Mice
Sign Up to like & getrecommendations! Published in 2019 at "Hepatology"
DOI: 10.1002/hep.30229
Abstract: Gastric mechanistic target of rapamycin (mTOR) signaling is inversely associated with the expression and secretion of ghrelin, a 28‐aa peptide hormone produced by gastric X/A‐like cells. Ghrelin contributes to obesity and hepatic steatosis. We sought… read more here.
Keywords: like cells; mtor signaling; mtor; signaling like ... See more keywords
Direct chemical induction of hepatocyte‐like cells with capacity for liver repopulation
Sign Up to like & getrecommendations! Published in 2022 at "Hepatology"
DOI: 10.1002/hep.32686
Abstract: Background and Aims: Cell fate can be directly reprogrammed from accessible cell types (e.g., fibroblasts) into functional cell types by exposure to small molecule stimuli. However, no chemical reprogramming method has been reported to date… read more here.
Keywords: chemical reprogramming; hepatocyte; hepatocyte like; like cells ... See more keywords
Three‐dimensional spheroid cell culture of human MSC‐derived neuron‐like cells: New in vitro model to assess magnetite nanoparticle‐induced neurotoxicity effects
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Applied Toxicology"
DOI: 10.1002/jat.4292
Abstract: As nanoparticles (NPs) can access the brain and impact on CNS function, novel in vitro models for the evaluation of NPs‐induced neurotoxicity are advocated. Three‐dimensional spheroids of primary neuron‐like cells (hNLCs) of human origin have… read more here.
Keywords: cell; induced neurotoxicity; neuron like; three dimensional ... See more keywords
Palmitic Acid Induced a Dedifferentiation Profile at the Transcriptome Level: A Collagen Synthesis but no Triglyceride Accumulation in Hepatocyte‐Like Cells Derived From Human‐Induced Pluripotent Stem Cells Cultivated Inside Organ on a Chip
Sign Up to like & getrecommendations! Published in 2024 at "Journal of Applied Toxicology"
DOI: 10.1002/jat.4714
Abstract: Nonalcoholic fatty liver disease (NAFLD) is one of the main causes of critical liver diseases leading to steatosis, steatohepatitis, fibrosis, and ultimately to liver cirrhosis and hepatic carcinoma. In this study, the effect of palmitic… read more here.
Keywords: like cells; hepatocyte like; accumulation; palmitic acid ... See more keywords