Hepatocyte‐like cells generated by direct reprogramming from murine somatic cells can repopulate decellularized livers
Sign Up to like & getrecommendations! Published in 2018 at "Biotechnology and Bioengineering"
DOI: 10.1002/bit.26784
Abstract: Direct reprogramming represents an easy technique to generate induced hepatocytes (iHeps) from somatic cells. However, current protocols are accompanied by several drawbacks as iHeps are heterogenous and lack fully mature phenotypes of primary hepatocytes. Here,… read more here.
Keywords: hepatocyte like; like cells; repopulate decellularized; direct reprogramming ... See more keywords
Knockdown of STAT3 targets a subpopulation of invasive melanoma stem‐like cells
Sign Up to like & getrecommendations! Published in 2019 at "Cell Biology International"
DOI: 10.1002/cbin.11134
Abstract: Transcription factor signal transducer and activator of transcription 3 (STAT3) is constitutively activated in many cancers, including melanomas. Active, phosphorylated STAT3 contributes to tumor growth and formation of the immunosuppressive tumor microenvironment. Recent evidence suggests… read more here.
Keywords: melanoma; melanoma cscs; like cells; stat3 ... See more keywords
mTOR Signaling in X/A‐Like Cells Contributes to Lipid Homeostasis in Mice
Sign Up to like & getrecommendations! Published in 2019 at "Hepatology"
DOI: 10.1002/hep.30229
Abstract: Gastric mechanistic target of rapamycin (mTOR) signaling is inversely associated with the expression and secretion of ghrelin, a 28‐aa peptide hormone produced by gastric X/A‐like cells. Ghrelin contributes to obesity and hepatic steatosis. We sought… read more here.
Keywords: like cells; mtor signaling; mtor; signaling like ... See more keywords
Direct chemical induction of hepatocyte‐like cells with capacity for liver repopulation
Sign Up to like & getrecommendations! Published in 2022 at "Hepatology"
DOI: 10.1002/hep.32686
Abstract: Background and Aims: Cell fate can be directly reprogrammed from accessible cell types (e.g., fibroblasts) into functional cell types by exposure to small molecule stimuli. However, no chemical reprogramming method has been reported to date… read more here.
Keywords: chemical reprogramming; hepatocyte; hepatocyte like; like cells ... See more keywords
Three‐dimensional spheroid cell culture of human MSC‐derived neuron‐like cells: New in vitro model to assess magnetite nanoparticle‐induced neurotoxicity effects
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Applied Toxicology"
DOI: 10.1002/jat.4292
Abstract: As nanoparticles (NPs) can access the brain and impact on CNS function, novel in vitro models for the evaluation of NPs‐induced neurotoxicity are advocated. Three‐dimensional spheroids of primary neuron‐like cells (hNLCs) of human origin have… read more here.
Keywords: cell; induced neurotoxicity; neuron like; three dimensional ... See more keywords
Exercise ameliorates high‐fat diet‐induced impairment of differentiation of adipose‐derived stem cells into neuron‐like cells in rats
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.26957
Abstract: Adipose‐derived stem cells (ADSCs) can differentiate into neurons under particular conditions. It remains largely unknown whether this differentiation potential is affected by physical conditions such as obesity, which modulates the functions of adipose tissue. In… read more here.
Keywords: hfd; adscs; like cells; differentiation ... See more keywords
Generation of insulin‐producing hepatocyte‐like cells from human Wharton's jelly mesenchymal stem cells as an alternative source of islet cells
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.28352
Abstract: Islet cell transplantation, as a treatment of type 1 diabetes, has a lot of complexity such as allograft rejections and an insufficient number of donors. The liver can be used as a replacement for endogenous… read more here.
Keywords: insulin; hepatocyte like; like cells; stem cells ... See more keywords
Enrichment of cancer stem‐like cells by the induction of epithelial‐mesenchymal transition using lentiviral vector carrying E‐cadherin shRNA in HT29 cell line
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.28855
Abstract: A better understanding of cancer stem cells (CSCs) may facilitate the prevention and treatment of cancers. Epithelial‐mesenchymal transition (EMT) is a process activated during invasion and metastasis of tumors. EMT induction in normal and tumor… read more here.
Keywords: cancer stem; cell line; like cells; cancer ... See more keywords
Effects of cell cycle phases on the induction of dental pulp stem cells toward dopaminergic‐like cells
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Tissue Engineering and Regenerative Medicine"
DOI: 10.1002/term.2401
Abstract: Parkinson's disease (PD) is characterized by tremors and cognitive issues, and is due to the death of dopaminergic (DA‐ergic) neurons in brain circuits that are responsible for producing neurotransmitter dopamine (DA). Currently, cell replacement therapies… read more here.
Keywords: stem cells; like cells; pulp stem; dental pulp ... See more keywords
In Vitro Generation of Stem Cell Memory-Like T Cells from Activated T Cells.
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DOI: 10.1007/978-1-0716-0266-9_11
Abstract: Adoptive T-cell therapy is an attractive strategy for cancer immunotherapy. The transfer of in vitro expanded tumor-associated antigen (TAA)-specific T cells from patients may effectively fight against the original tumor cells. The chimeric antigen receptor-engineered… read more here.
Keywords: stem cell; like cells; cell memory; activated cells ... See more keywords
In Vitro Conversion of Murine Fibroblasts into Cardiomyocyte-Like Cells.
Sign Up to like & getrecommendations! Published in 2021 at "Methods in molecular biology"
DOI: 10.1007/978-1-0716-0668-1_12
Abstract: Direct reprogramming of fibroblasts into induced cardiomyocytes (iCMs) holds great promise as a potential treatment for cardiovascular disease, many of which are associated with tremendous loss of functional cardiomyocytes and simultaneous formation of scar tissue.… read more here.
Keywords: cardiomyocyte like; fibroblasts cardiomyocyte; conversion murine; like cells ... See more keywords