Involvement of acute neuroinflammation in postoperative delirium-like cognitive deficits in rats
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DOI: 10.1007/s00540-018-2504-x
Abstract: PurposeThe purpose of this study was to investigate the age-, time-, and brain region-dependent postoperative neuroinflammatory trajectory, and its association with neurocognitive outcomes in rats.MethodsAdult and aged rats were randomly assigned to one of three… read more here.
Keywords: delirium like; acute neuroinflammation; like cognitive; neuroinflammation ... See more keywords
The role of optogenetic stimulations of parvalbumin-positive interneurons in the prefrontal cortex and the ventral hippocampus on an acute MK-801 model of schizophrenia-like cognitive inflexibility
Sign Up to like & getrecommendations! Published in 2022 at "Schizophrenia Research"
DOI: 10.1101/2022.03.25.485752
Abstract: Background and Hypothesis Schizophrenia research arose in the last decades, focusing more on its neural basis. Executive functions such as decision making and cognitive flexibility are the main cognitive areas that are impaired and are… read more here.
Keywords: cognitive inflexibility; model; like cognitive; schizophrenia like ... See more keywords
Fingolimod ameliorates schizophrenia‐like cognitive impairments induced by phencyclidine in male rats
Sign Up to like & getrecommendations! Published in 2022 at "British Journal of Pharmacology"
DOI: 10.1111/bph.15954
Abstract: Improvement of cognitive deficits in schizophrenia remains an unmet need owing to the lack of new therapies and drugs. Recent studies have reported that fingolimod, an immunomodulatory drug for treating multiple sclerosis, demonstrates anti‐inflammatory and… read more here.
Keywords: impairments induced; ameliorates schizophrenia; fingolimod ameliorates; like cognitive ... See more keywords