Intranasal Delivery of Near‐Infrared and Magnetic Dual‐Response Nanospheres to Rapidly Produce Antidepressant‐Like and Cognitive Enhancement Effects
Sign Up to like & getrecommendations! Published in 2024 at "Advanced Materials"
DOI: 10.1002/adma.202405547
Abstract: Restricted by synaptic plasticity, dopamine receptor (DR) upregulation takes a long time to work. Moreover, the impact of the blood–brain barrier (BBB) on delivery efficiency restricts the development of drugs. Taking inspiration from snuff bottles,… read more here.
Keywords: delivery; like cognitive; cognitive enhancement; antidepressant like ... See more keywords
Involvement of acute neuroinflammation in postoperative delirium-like cognitive deficits in rats
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Anesthesia"
DOI: 10.1007/s00540-018-2504-x
Abstract: PurposeThe purpose of this study was to investigate the age-, time-, and brain region-dependent postoperative neuroinflammatory trajectory, and its association with neurocognitive outcomes in rats.MethodsAdult and aged rats were randomly assigned to one of three… read more here.
Keywords: delirium like; acute neuroinflammation; like cognitive; neuroinflammation ... See more keywords
Organophosphate Insecticide Malathion Induces Alzheimer's Disease-Like Cognitive Impairment in Mice: Evidence of the Microbiota-Gut-Brain Axis.
Sign Up to like & getrecommendations! Published in 2024 at "Environmental science & technology"
DOI: 10.1021/acs.est.4c07427
Abstract: Evidence suggests that exposure to organophosphate pesticides increases the risk of neurodegenerative diseases, but the mechanisms remain unclear. This study investigated the effects of malathion on Alzheimer's disease (AD)-like symptoms at environmentally relevant concentrations using… read more here.
Keywords: mice; cognitive impairment; disease; like cognitive ... See more keywords
The role of optogenetic stimulations of parvalbumin-positive interneurons in the prefrontal cortex and the ventral hippocampus on an acute MK-801 model of schizophrenia-like cognitive inflexibility
Sign Up to like & getrecommendations! Published in 2022 at "Schizophrenia Research"
DOI: 10.1101/2022.03.25.485752
Abstract: Background and Hypothesis Schizophrenia research arose in the last decades, focusing more on its neural basis. Executive functions such as decision making and cognitive flexibility are the main cognitive areas that are impaired and are… read more here.
Keywords: cognitive inflexibility; model; like cognitive; schizophrenia like ... See more keywords
Fingolimod ameliorates schizophrenia‐like cognitive impairments induced by phencyclidine in male rats
Sign Up to like & getrecommendations! Published in 2022 at "British Journal of Pharmacology"
DOI: 10.1111/bph.15954
Abstract: Improvement of cognitive deficits in schizophrenia remains an unmet need owing to the lack of new therapies and drugs. Recent studies have reported that fingolimod, an immunomodulatory drug for treating multiple sclerosis, demonstrates anti‐inflammatory and… read more here.
Keywords: impairments induced; ameliorates schizophrenia; fingolimod ameliorates; like cognitive ... See more keywords