Beta-strand-mediated dimeric formation of the Ig-like domains of human lamin A/C and B1.
Sign Up to like & getrecommendations! Published in 2021 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2021.02.102
Abstract: Lamins are nuclear intermediate filament proteins that play an essential role in maintaining the nuclear structure by forming a 3-D meshwork. Lamins consist of the N-terminal unstructured head, the coiled-coil rod domain, and the C-terminal… read more here.
Keywords: human lamin; like domain; beta strand; structure ... See more keywords
Amyloid-like Assembly Activates a Phosphatase in the Developing Drosophila Embryo
Sign Up to like & getrecommendations! Published in 2019 at "Cell"
DOI: 10.1016/j.cell.2019.08.019
Abstract: Prion-like proteins can assume distinct conformational and physical states in the same cell. Sequence analysis suggests that prion-like proteins are prevalent in various species; however, it remains unclear what functional space they occupy in multicellular… read more here.
Keywords: like assembly; amyloid like; prion like; prion ... See more keywords
A compact embedding result for anisotropic Sobolev spaces associated to a strip-like domain and some applications
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Mathematical Analysis and Applications"
DOI: 10.1016/j.jmaa.2019.123490
Abstract: Abstract Let m ≥ 1 and d ≥ 2 be integers and consider a strip-like domain O × R d , where O ⊂ R m is a bounded Euclidean domain with smooth boundary. Furthermore,… read more here.
Keywords: applications compact; compact embedding; like domain; strip like ... See more keywords
d-Stereoisomer preference of the OmpA-like domain of Pal in peptidoglycan of Acinetobacter baumannii
Sign Up to like & getrecommendations! Published in 2017 at "Process Biochemistry"
DOI: 10.1016/j.procbio.2017.01.009
Abstract: Abstract OmpA-like domain proteins bind to peptidoglycan by interacting with the d -amino acid moiety of meso -diaminopimelate in peptidoglycan, but it is still not clear how this domain recognizes the d -amino region of… read more here.
Keywords: stereoisomer preference; like domain; ompa like; diaminopimelate ... See more keywords
Targeting the Hemopexin-like Domain of Latent Matrix Metalloproteinase-9 (proMMP-9) with a Small Molecule Inhibitor Prevents the Formation of Focal Adhesion Junctions
Sign Up to like & getrecommendations! Published in 2017 at "ACS Chemical Biology"
DOI: 10.1021/acschembio.7b00758
Abstract: A lack of target specificity has greatly hindered the success of inhibitor development against matrix metalloproteinases (MMPs) for the treatment of various cancers. The MMP catalytic domains are highly conserved, whereas the hemopexin-like domains of… read more here.
Keywords: hemopexin; hemopexin like; like domain; targeting hemopexin ... See more keywords
Molecular mechanism of calcium induced trimerization of C1q-like domain of otolin-1 from human and zebrafish
Sign Up to like & getrecommendations! Published in 2021 at "Scientific Reports"
DOI: 10.1038/s41598-021-92129-8
Abstract: The C1q superfamily includes proteins involved in innate immunity, insulin sensitivity, biomineralization and more. Among these proteins is otolin-1, which is a collagen-like protein that forms a scaffold for the biomineralization of inner ear stones… read more here.
Keywords: gc1q otolin; like domain; molecular mechanism; c1q like ... See more keywords
SMCHD1's ubiquitin-like domain is required for N-terminal dimerization and chromatin localization
Sign Up to like & getrecommendations! Published in 2021 at "Biochemical Journal"
DOI: 10.1042/bcj20210278
Abstract: Structural maintenance of chromosomes flexible hinge domain-containing 1 (SMCHD1) is an epigenetic regulator that mediates gene expression silencing at targeted sites across the genome. Our current understanding of SMCHD1's molecular mechanism, and how substitutions within… read more here.
Keywords: like domain; chromatin; smchd1; dimerization ... See more keywords
Evolution and diversification of the ACT-like domain associated with plant basic helix-loop-helix transcription factors.
Sign Up to like & getrecommendations! Published in 2023 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2219469120
Abstract: Basic helix-loop-helix (bHLH) proteins are one of the largest families of transcription factor (TF) in eukaryotes, and ~30% of all flowering plants' bHLH TFs contain the aspartate kinase, chorismate mutase, and TyrA (ACT)-like domain at… read more here.
Keywords: act; act like; like domain; helix ... See more keywords
A prion-like domain of TFEB mediates the co-aggregation of TFEB and mHTT
Sign Up to like & getrecommendations! Published in 2022 at "Autophagy"
DOI: 10.1080/15548627.2022.2083857
Abstract: ABSTRACT The aggregation of mutant HTT (huntingtin; mHTT) is a hallmark of Huntington disease (HD). mHTT aggregates interact and sequester dozens of proteins and affect diverse key cellular functions. Here we report that TFEB (transcription… read more here.
Keywords: tfeb; aggregation; prion like; mhtt ... See more keywords
Pleckstrin homology-like domain family A, member 3, a miR-19a-3p-regulated gene, suppresses tumor growth in osteosarcoma by downregulating the Akt pathway
Sign Up to like & getrecommendations! Published in 2022 at "Bioengineered"
DOI: 10.1080/21655979.2022.2031404
Abstract: ABSTRACT Pleckstrin homology-like domain family A, member 3 (PHLDA3), is emerging as a critical regulator for multiple cancers. Nevertheless, the expression and role of PHLDA3 in osteosarcoma remain unknown. Herein, we purposed to elucidate the… read more here.
Keywords: homology like; osteosarcoma; mir 19a; pleckstrin homology ... See more keywords
Role of the lectin-like domain of thrombomodulin in septic cardiomyopathy.
Sign Up to like & getrecommendations! Published in 2022 at "Life sciences"
DOI: 10.2139/ssrn.4051242
Abstract: AIMS Septic cardiomyopathy is a severe complication of sepsis and septic shock. This study aimed to evaluate the role of thrombomodulin and its lectin-like domain (LLD-TM) in the development of septic cardiomyopathy and the link… read more here.
Keywords: lectin like; septic cardiomyopathy; cardiac function; like domain ... See more keywords