Antidepressant‐like effect of flaxseed in rats exposed to chronic unpredictable stress
Sign Up to like & getrecommendations! Published in 2020 at "Brain and Behavior"
DOI: 10.1002/brb3.1626
Abstract: Depression is a serious mental illness. However, a significant proportion of patients with depression fail to achieve remission with antidepressant therapies. This study was conducted to explore the antidepressant‐like effect of flaxseed oil and flour… read more here.
Keywords: unpredictable stress; chronic unpredictable; like effect; effect flaxseed ... See more keywords
Activation of astrocytic sigma‐1 receptor exerts antidepressant‐like effect via facilitating CD38‐driven mitochondria transfer
Sign Up to like & getrecommendations! Published in 2020 at "Glia"
DOI: 10.1002/glia.23850
Abstract: Despite sigma‐1 receptor (Sig‐1R) is a promising therapeutic target in depression, little is known regarding the cellular mechanisms underlying its antidepressant responses. Here, we demonstrated that astrocyte can be a direct cellular target of Sig‐1R… read more here.
Keywords: like effect; activation; sigma receptor; sig ... See more keywords
Dihydromyricetin exerts a rapid antidepressant-like effect in association with enhancement of BDNF expression and inhibition of neuroinflammation
Sign Up to like & getrecommendations! Published in 2017 at "Psychopharmacology"
DOI: 10.1007/s00213-017-4761-z
Abstract: RationaleMajor depressive disorder (MDD) is a highly prevalent illness that affects large populations across the world, and increasing evidence suggests that neuroinflammation and levels of brain-derived neurotrophic factor (BDNF) are closely related to depression. Dihydromyricetin… read more here.
Keywords: depression; like effect; effect; antidepressant like ... See more keywords
The antidepressant-like effect of guanosine is dependent on GSK-3β inhibition and activation of MAPK/ERK and Nrf2/heme oxygenase-1 signaling pathways
Sign Up to like & getrecommendations! Published in 2019 at "Purinergic Signalling"
DOI: 10.1007/s11302-019-09681-2
Abstract: Although guanosine is an endogenous nucleoside that displays antidepressant-like properties in several animal models, the mechanism underlying its antidepressant-like effects is not well characterized. The present study aimed at investigating the involvement of ERK/GSK-3β and… read more here.
Keywords: like effect; gsk; effect guanosine; antidepressant like ... See more keywords
Antidepressant-Like Effect of the Endogenous Neuroprotective Amine, 1MeTIQ in Clonidine-Induced Depression: Behavioral and Neurochemical Studies in Rats
Sign Up to like & getrecommendations! Published in 2017 at "Neurotoxicity Research"
DOI: 10.1007/s12640-017-9715-z
Abstract: Biogenic amines such as norepinephrine, dopamine, and serotonin play a well-described role in the treatment of mood disorders especially depression. Animal models are widely used to study antidepressant-like effect in rodents; however, it should be… read more here.
Keywords: like effect; clonidine induced; clonidine; endogenous neuroprotective ... See more keywords
Antidepressant-like effect of pramipexole in an inflammatory model of depression
Sign Up to like & getrecommendations! Published in 2017 at "Behavioural Brain Research"
DOI: 10.1016/j.bbr.2016.11.007
Abstract: Graphical abstract Figure. No Caption available. HighlightsPramipexole (PPX) for 7 days prevented LPS‐induced depressant‐like behavior in mice.PPX prevented the LPS‐induced increase in IL‐1&bgr; in the hippocampus.PPX abolished the LPS‐induced increase in hippocampal protein 3‐nitrotyrosine.D2 receptor… read more here.
Keywords: like effect; ppx; inflammatory; effect ... See more keywords
Antidepressant-like effect of valproic acid—Possible involvement of PI3K/Akt/mTOR pathway
Sign Up to like & getrecommendations! Published in 2017 at "Behavioural Brain Research"
DOI: 10.1016/j.bbr.2017.04.015
Abstract: Rationale: Few studies suggest that antidepressants exert their effects by activating some signaling pathways, including the phosphatidylinositol 3‐kinase (PI3K). Moreover, valproic acid (VPA) activates the PI3K pathway. Thus, here we investigated the antidepressant‐like effect of… read more here.
Keywords: pi3k ggr; like effect; effect; mtor ... See more keywords
Potential antidepressant-like effect of piperazine derivative LQFM212 in mice: Role of monoaminergic pathway and brain-derived neurotrophic factor
Sign Up to like & getrecommendations! Published in 2021 at "Behavioural Brain Research"
DOI: 10.1016/j.bbr.2020.113066
Abstract: Major depression disorder (MDD) is one of the most widespread and debilitating psychiatric diseases and may be associated with other mental disorders such as anxiety. Despite advances in neurobiology studies, currently no established mechanism can… read more here.
Keywords: monoaminergic pathway; lqfm212; like effect; antidepressant like ... See more keywords
FGF-2 signaling activation in the hippocampus contributes to the behavioral and cellular responses to puerarin.
Sign Up to like & getrecommendations! Published in 2019 at "Biochemical pharmacology"
DOI: 10.1016/j.bcp.2019.06.025
Abstract: Puerarin, a well-studied isoflavone isolated from Pueraria lobata, produces an antidepressant-like effect. Fibroblast growth factor-2 (FGF-2) is essentially required in the central nervous system as it acts as both a neurotrophic or anti-inflammatory regulator for… read more here.
Keywords: fgf; hippocampus; puerarin; like effect ... See more keywords
A proposed "steric-like effect" for the slowdown of enrofloxacin antibiotic metabolism by ciprofloxacin, and its mechanism.
Sign Up to like & getrecommendations! Published in 2021 at "Chemosphere"
DOI: 10.1016/j.chemosphere.2021.131347
Abstract: The results of monitoring over the years have shown that the mixing and coexistence of various low-level antibiotic residual pollutants has increased significantly, among which, the problems of enrofloxacin (ENR) and ciprofloxacin (CIP) were more… read more here.
Keywords: enr; metabolism; like effect; effect ... See more keywords
Depletion of 5 hydroxy-triptamine (5-HT) affects the antidepressant-like effect of neuronal nitric oxide synthase inhibitor in mice
Sign Up to like & getrecommendations! Published in 2017 at "Neuroscience Letters"
DOI: 10.1016/j.neulet.2017.07.035
Abstract: Clinical and experimental evidence indicates that nitric oxide (NO) is involved in the genesis of depression as well as in antidepressant drug effects. Inhibitors of nitric oxide synthases (NOS) exert antidepressant-like effect in several animal… read more here.
Keywords: like effect; effect; like effects; nitric oxide ... See more keywords