Pharmacological basis for sedative and hypnotic like effects of Pyrus pashia using in vivo experimental models
Sign Up to like & getrecommendations! Published in 2019 at "International Journal of Geriatric Psychiatry"
DOI: 10.1002/gps.5059
Abstract: Pyrus pashia has traditionally been used as a therapeutic agent including sedative. In this regard, hydroethanolic extract of Pyrus pashia (HEPP) was screened for phytochemical investigation, acute toxicity, and sedative‐hypnotic activity to provide a scientific… read more here.
Keywords: hypnotic like; basis sedative; sedative hypnotic; pyrus pashia ... See more keywords
Assessing potential reinforcement-like effects of brief stimuli unrelated to food reinforcers.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of the experimental analysis of behavior"
DOI: 10.1002/jeab.580
Abstract: It is widely assumed that reinforcers are biologically relevant stimuli, or stimuli that have been associated with biologically relevant stimuli. However, brief, arbitrary stimuli have also been reported to have reinforcement-like effects, despite being unrelated… read more here.
Keywords: brief stimuli; reinforcement like; like effects; potential reinforcement ... See more keywords
Delta Opioid Receptors and Modulation of Mood and Emotion.
Sign Up to like & getrecommendations! Published in 2018 at "Handbook of experimental pharmacology"
DOI: 10.1007/164_2017_42
Abstract: Depression is a pervasive and debilitating mental disorder that is inadequately treated by current pharmacotherapies in a majority of patients. Although opioids have long been known to regulate mood states, the use of opioids to… read more here.
Keywords: dor agonists; like effects; mood; delta opioid ... See more keywords
The anxiolytic-like effects of puerarin are associated with the changes of monoaminergic neurotransmitters and biosynthesis of allopregnanolone in the brain
Sign Up to like & getrecommendations! Published in 2017 at "Metabolic Brain Disease"
DOI: 10.1007/s11011-017-0127-9
Abstract: Anxiety disorder is a serious and burdensome psychiatric illness that frequently turn into chronic clinical conditions. Puerarin have been shown to be effective in the therapy of depression. However, few studies are concerned about the… read more here.
Keywords: biosynthesis allopregnanolone; effects puerarin; anxiolytic like; like effects ... See more keywords
Cannabidiol Induces Rapid and Sustained Antidepressant-Like Effects Through Increased BDNF Signaling and Synaptogenesis in the Prefrontal Cortex
Sign Up to like & getrecommendations! Published in 2018 at "Molecular Neurobiology"
DOI: 10.1007/s12035-018-1143-4
Abstract: Currently available antidepressants have a substantial time lag to induce therapeutic response and a relatively low efficacy. The development of drugs that addresses these limitations is critical to improving public health. Cannabidiol (CBD), a non-psychotomimetic… read more here.
Keywords: rapid sustained; like effects; sustained antidepressant; antidepressant like ... See more keywords
Pharmacological evidence for the relationship between the NMDA receptor and nitric oxide pathway and the antidepressant-like effects of glucagon-like peptide-2 in the mouse forced-swim test
Sign Up to like & getrecommendations! Published in 2019 at "Behavioural Brain Research"
DOI: 10.1016/j.bbr.2019.02.028
Abstract: Highlightsd‐serine and l‐arginine inhibited the antidepressant‐like effects of GLP‐2 in the mouse FST.PDE5 inhibitor inhibited the antidepressant‐like effects of GLP‐2.GLP‐2 and NMDA receptor‐NO‐cGMP pathway exerted synergistic effects in the FST. &NA; We previously demonstrated that… read more here.
Keywords: effects glp; nmda receptor; like effects; nitric oxide ... See more keywords
Fucoidan exerts antidepressant-like effects in mice via regulating the stability of surface AMPARs.
Sign Up to like & getrecommendations! Published in 2019 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2019.10.043
Abstract: The inflammatory hypothesis is one of the most important mechanisms of depression. Fucoidan is a bioactive sulfated polysaccharide abundant in brown seaweeds with anti-inflammatory activity. However, the antidepressant effects of fucoidan on chronic stress-induced depressive-like… read more here.
Keywords: exerts antidepressant; like effects; depressive like; fucoidan exerts ... See more keywords
Antidepressant-like effects of ginsenoside Rg2 in a chronic mild stress model of depression
Sign Up to like & getrecommendations! Published in 2017 at "Brain Research Bulletin"
DOI: 10.1016/j.brainresbull.2017.08.009
Abstract: Major depression is a common neuropsychiatric disease with high lifetime prevalence and high incidence of suicide. This study aimed to evaluate the antidepressant effects of ginsenoside Rg2 in mice, and the possible mechanism was also… read more here.
Keywords: effects ginsenoside; like effects; chronic mild; mild stress ... See more keywords
Repeated arctigenin treatment produces antidepressant- and anxiolytic-like effects in mice
Sign Up to like & getrecommendations! Published in 2019 at "Brain Research Bulletin"
DOI: 10.1016/j.brainresbull.2018.12.005
Abstract: Depression is the root of various diseases. It is one of the most debilitating conditions globally. Antidepressant drugs are usually the first-line of depression treatment. Arctigenin (ARC), one of active ingredient of Arctium lappa L,… read more here.
Keywords: arc administration; antidepressant anxiolytic; treatment; like effects ... See more keywords
Anxiolytic and panicolytic-like effects of environmental enrichment seem to be modulated by serotonin neurons located in the dorsal subnucleus of the dorsal raphe
Sign Up to like & getrecommendations! Published in 2019 at "Brain Research Bulletin"
DOI: 10.1016/j.brainresbull.2019.06.012
Abstract: In a previous study, we showed that exposure of rats to a one-week environmental enrichment (EE) protocol decreases elevated T-maze (ETM) avoidance responses, an anxiolytic-like effect, without altering escape reactions, in clinical terms related to… read more here.
Keywords: anxiolytic panicolytic; panicolytic like; like effects; dorsal ... See more keywords
Intranasal administration of transforming growth factor-β1 elicits rapid-acting antidepressant-like effects in a chronic social defeat stress model: A role of TrkB signaling
Sign Up to like & getrecommendations! Published in 2021 at "European Neuropsychopharmacology"
DOI: 10.1016/j.euroneuro.2021.04.010
Abstract: (R,S)-ketamine causes rapid-acting and sustained antidepressant effects in treatment-resistant patients with depression although the precise molecular mechanisms underlying its antidepressant action remain unclear. We recently reported that transforming growth factor (TGF)-β1 might contribute to the… read more here.
Keywords: trkb signaling; rapid acting; like effects; intranasal administration ... See more keywords