Citronellal Exerts Sedative‐Like Effects and Augments Diazepam's Action in Swiss Mice, Possibly Through the GABAergic Pathway
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DOI: 10.1002/brb3.70446
Abstract: Citronellal (CTL), a monoterpenoid, exhibits notable neurological activity, including anxiolytic, and anticonvulsant effects, primarily through GABAergic pathways. Our current study aimed to explore CTL's sedative potential using in vitro, in vivo, and in silico approaches… read more here.
Keywords: citronellal; like effects; citronellal exerts; sedative like ... See more keywords
Pharmacological basis for sedative and hypnotic like effects of Pyrus pashia using in vivo experimental models
Sign Up to like & getrecommendations! Published in 2019 at "International Journal of Geriatric Psychiatry"
DOI: 10.1002/gps.5059
Abstract: Pyrus pashia has traditionally been used as a therapeutic agent including sedative. In this regard, hydroethanolic extract of Pyrus pashia (HEPP) was screened for phytochemical investigation, acute toxicity, and sedative‐hypnotic activity to provide a scientific… read more here.
Keywords: hypnotic like; basis sedative; sedative hypnotic; pyrus pashia ... See more keywords
Assessing potential reinforcement-like effects of brief stimuli unrelated to food reinforcers.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of the experimental analysis of behavior"
DOI: 10.1002/jeab.580
Abstract: It is widely assumed that reinforcers are biologically relevant stimuli, or stimuli that have been associated with biologically relevant stimuli. However, brief, arbitrary stimuli have also been reported to have reinforcement-like effects, despite being unrelated… read more here.
Keywords: brief stimuli; reinforcement like; like effects; potential reinforcement ... See more keywords
Delta Opioid Receptors and Modulation of Mood and Emotion.
Sign Up to like & getrecommendations! Published in 2018 at "Handbook of experimental pharmacology"
DOI: 10.1007/164_2017_42
Abstract: Depression is a pervasive and debilitating mental disorder that is inadequately treated by current pharmacotherapies in a majority of patients. Although opioids have long been known to regulate mood states, the use of opioids to… read more here.
Keywords: dor agonists; like effects; mood; delta opioid ... See more keywords
Beyond fixed sets: boundary conditions for obtaining SNARC-like effects with continuous semantic magnitudes
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DOI: 10.1007/s00426-024-01972-7
Abstract: Previous research has demonstrated the presence of an effect (i.e., the spatial-numerical association of response codes or SNARC) in both numerical parity and magnitude judgment tasks in which smaller numerical magnitudes are manually responded to… read more here.
Keywords: snarc like; fixed sets; like effects; beyond fixed ... See more keywords
The anxiolytic-like effects of puerarin are associated with the changes of monoaminergic neurotransmitters and biosynthesis of allopregnanolone in the brain
Sign Up to like & getrecommendations! Published in 2017 at "Metabolic Brain Disease"
DOI: 10.1007/s11011-017-0127-9
Abstract: Anxiety disorder is a serious and burdensome psychiatric illness that frequently turn into chronic clinical conditions. Puerarin have been shown to be effective in the therapy of depression. However, few studies are concerned about the… read more here.
Keywords: biosynthesis allopregnanolone; effects puerarin; anxiolytic like; like effects ... See more keywords
Cannabidiol Induces Rapid and Sustained Antidepressant-Like Effects Through Increased BDNF Signaling and Synaptogenesis in the Prefrontal Cortex
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DOI: 10.1007/s12035-018-1143-4
Abstract: Currently available antidepressants have a substantial time lag to induce therapeutic response and a relatively low efficacy. The development of drugs that addresses these limitations is critical to improving public health. Cannabidiol (CBD), a non-psychotomimetic… read more here.
Keywords: rapid sustained; like effects; sustained antidepressant; antidepressant like ... See more keywords
Fast-acting antidepressant-like effects of ketamine in aged male rats
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DOI: 10.1007/s43440-024-00636-y
Abstract: The aging process causes anatomical and physiological changes that predispose to the development of late-life depression while reduces the efficacy of classical antidepressants. Novel fast-acting antidepressants such as ketamine might be good candidates to be… read more here.
Keywords: fast acting; effects ketamine; like effects; acting antidepressant ... See more keywords
Pharmacological evidence for the relationship between the NMDA receptor and nitric oxide pathway and the antidepressant-like effects of glucagon-like peptide-2 in the mouse forced-swim test
Sign Up to like & getrecommendations! Published in 2019 at "Behavioural Brain Research"
DOI: 10.1016/j.bbr.2019.02.028
Abstract: Highlightsd‐serine and l‐arginine inhibited the antidepressant‐like effects of GLP‐2 in the mouse FST.PDE5 inhibitor inhibited the antidepressant‐like effects of GLP‐2.GLP‐2 and NMDA receptor‐NO‐cGMP pathway exerted synergistic effects in the FST. &NA; We previously demonstrated that… read more here.
Keywords: effects glp; nmda receptor; like effects; nitric oxide ... See more keywords
Fucoidan exerts antidepressant-like effects in mice via regulating the stability of surface AMPARs.
Sign Up to like & getrecommendations! Published in 2019 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2019.10.043
Abstract: The inflammatory hypothesis is one of the most important mechanisms of depression. Fucoidan is a bioactive sulfated polysaccharide abundant in brown seaweeds with anti-inflammatory activity. However, the antidepressant effects of fucoidan on chronic stress-induced depressive-like… read more here.
Keywords: exerts antidepressant; like effects; depressive like; fucoidan exerts ... See more keywords
Antidepressant-like effects of ginsenoside Rg2 in a chronic mild stress model of depression
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DOI: 10.1016/j.brainresbull.2017.08.009
Abstract: Major depression is a common neuropsychiatric disease with high lifetime prevalence and high incidence of suicide. This study aimed to evaluate the antidepressant effects of ginsenoside Rg2 in mice, and the possible mechanism was also… read more here.
Keywords: effects ginsenoside; like effects; chronic mild; mild stress ... See more keywords