Clinical features, pathogenesis, and management of stroke-like episodes due to MELAS.
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DOI: 10.1007/s11011-021-00772-x
Abstract: Mitochondrial encephalomyopathy with lactic acidosis and stroke-like episodes (MELAS) is a disease that should be considered as a differential diagnosis to acute ischemic stroke taking into account its onset pattern and neurological symptoms, which are… read more here.
Keywords: clinical features; like episodes; pathogenesis management; stroke like ... See more keywords
Survival analysis of a cohort of Chinese patients with mitochondrial encephalomyopathy with lactic acidosis and stroke-like episodes (MELAS) based on clinical features
Sign Up to like & getrecommendations! Published in 2018 at "Journal of the Neurological Sciences"
DOI: 10.1016/j.jns.2017.12.033
Abstract: BACKGROUND Mitochondrial encephalomyopathy with lactic acidosis and stroke-like episodes (MELAS) is a common mitochondrial syndrome. The aim of this study was to conduct a survival analysis based on the clinical features of a Chinese MELAS… read more here.
Keywords: cohort; survival analysis; like episodes; stroke like ... See more keywords
Therapeutic management of stroke-like episodes varies from that of encephalitis
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DOI: 10.1097/md.0000000000019141
Abstract: Abstract Introduction: Stroke-like episodes (SLEs) are typical cerebral manifestations of certain mitochondrial disorders (MIDs). They are characterised by a vasogenic edema in a non-vascular distribution. Patients concerns: none Diagnosis: SLEs show up on cerebral MRI… read more here.
Keywords: therapeutic management; like episodes; chronic stage; stroke ... See more keywords
Diffuse posterior leukoencephalopathy in MELAS without stroke-like episodes: A case report
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DOI: 10.1097/md.0000000000033725
Abstract: Rationale: Mitochondrial encephalopathy, lactic acidosis, and stroke-like episodes (MELAS) is the most common subtype of mitochondrial encephalopathy. In the past, it was believed that most hereditary white matter lesions were lysosome storage disorders or peroxisome… read more here.
Keywords: stroke like; like episodes; matter lesions; white matter ... See more keywords
Clinical and radiological description of 120 pediatric stroke-like episodes.
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DOI: 10.1111/ene.15821
Abstract: Stroke‐like episodes (SLEs) are defined as acute onset of neurological symptoms mimicking a stroke and radiological lesions non‐congruent to vascular territory. We aimed to analyze the acute clinical and radiological features of SLEs to determine… read more here.
Keywords: stroke like; clinical radiological; radiological description; description 120 ... See more keywords
L-arginine in Mitochondrial Encephalopathy, Lactic Acidosis, and Stroke-like Episodes: A Systematic Review.
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DOI: 10.1212/wnl.0000000000200299
Abstract: OBJECTIVE Stroke management in the context of primary mitochondrial disease is clinically challenging and the best treatment options for patients with stroke-like episodes remain uncertain. We sought to perform a systematic review on the safety… read more here.
Keywords: like episodes; treatment; arginine; stroke like ... See more keywords
Stroke-like Episodes in m.3243A≥G Carriers Need to Be Monitored by MRI Starting with the Onset of Clinical Manifestations
Sign Up to like & getrecommendations! Published in 2020 at "American Journal of Neuroradiology"
DOI: 10.3174/ajnr.a6418
Abstract: With interest, we read the article by Bhatia et al[1][1] about a retrospective study of 8 patients with genetically confirmed mitochondrial encephalopathy with lactic acidosis and stroke-like episodes (MELAS). It was found that among 31… read more here.
Keywords: episodes 3243a; like episodes; stroke like; carriers need ... See more keywords
The Usefulness of Muscle Biopsy in Initial Diagnostic Evaluation of Mitochondrial Encephalomyopathy, Lactic Acidosis, and Stroke-Like Episodes
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DOI: 10.3349/ymj.2019.60.1.98
Abstract: Purpose The disease entity mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes (MELAS) is characterized by an early onset of stroke-like episodes. MELAS is the most dominant subtype of mitochondrial disease. Molecular genetic testing is important… read more here.
Keywords: muscle; muscle biopsy; pathology; like episodes ... See more keywords
Can Intestinal Pseudo-Obstruction Drive Recurrent Stroke-Like Episodes in Late-Onset MELAS Syndrome? A Case Report and Review of the Literature
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DOI: 10.3389/fneur.2019.00038
Abstract: Mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes (MELAS) syndrome is a maternally inherited mitochondrial disorder that is most commonly caused by the m. 3243A>G mutation in the MT-TL1 mitochondrial DNA gene, resulting in impairment of… read more here.
Keywords: pseudo obstruction; melas syndrome; like episodes; intestinal pseudo ... See more keywords
Mitochondrial encephalomyopathy with lactic acidosis and stroke-like episodes with an MT-TL1 m.3243A>G point mutation: Neuroradiological features and their implications for underlying pathogenesis
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Neuroscience"
DOI: 10.3389/fnins.2022.1028762
Abstract: Objective Mitochondrial encephalomyopathy with lactic acidosis and stroke−like episodes (MELAS) is one of the most common inherited mitochondrial disorders. Due to the high clinical and genetic heterogeneity of MELAS, it is still a major challenge… read more here.
Keywords: stroke like; lactic acidosis; like episodes; encephalomyopathy lactic ... See more keywords