Optimization of the first small-molecule relaxin/insulin-like family peptide receptor (RXFP1) agonists: Activation results in an antifibrotic gene expression profile.
Sign Up to like & getrecommendations! Published in 2018 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2018.06.008
Abstract: A dose responsive quantitative high throughput screen (qHTS) of >350,000 compounds against a human relaxin/insulin-like family peptide receptor (RXFP1) transfected HEK293 cell line identified 2-acetamido-N-phenylbenzamides 1 and 3 with modest agonist activity. An extensive structure-activity study… read more here.
Keywords: like family; family peptide; insulin like; receptor rxfp1 ... See more keywords
Apolipoprotein B mRNA editing enzyme catalytic polypeptide‐like family genes activation and regulation during tumorigenesis
Sign Up to like & getrecommendations! Published in 2018 at "Cancer Science"
DOI: 10.1111/cas.13658
Abstract: Cancer is currently viewed as a disease of evolving genomic instability and abnormal epigenomic modifications. Most solid cancers harbor oncogenic gene mutations driven by both extrinsic and intrinsic factors. Apolipoprotein B mRNA editing catalytic polypeptide‐like… read more here.
Keywords: catalytic polypeptide; like family; polypeptide like; mrna editing ... See more keywords
Vestigial‐like family member 3 stimulates cell motility by inducing high‐mobility group AT‐hook 2 expression in cancer cells
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Cellular and Molecular Medicine"
DOI: 10.1111/jcmm.17279
Abstract: Vestigial‐like family member 3 (VGLL3) is a cofactor for TEA domain transcription factors (TEADs). Although VGLL3 is known to be highly expressed and stimulate cell proliferation in mesenchymal cancer cells, its involvement in mesenchymal phenotypes… read more here.
Keywords: cancer; vestigial like; expression; like family ... See more keywords
Analysis of the complete genome sequences of Clostridium perfringens strains harbouring the binary enterotoxin BEC gene and comparative genomics of pCP13-like family plasmids
Sign Up to like & getrecommendations! Published in 2022 at "BMC Genomics"
DOI: 10.1186/s12864-022-08453-4
Abstract: Background BEC-producing Clostridium perfringens is a causative agent of foodborne gastroenteritis. It was first reported in 2014, and since then, several isolates have been identified in Japan and the United Kingdom. The novel binary ADP-ribosylating… read more here.
Keywords: like family; pcp13 like; complete genome; bec ... See more keywords
What Does it Feel Like to Have a Family Member Go Through Cancer?
Sign Up to like & getrecommendations! Published in 2022 at "Clinical journal of oncology nursing"
DOI: 10.1188/22.cjon.456
Abstract: Cancer comes into our lives uninvited like a relative who drops their suitcase on your couch without warning. It is an alien intruder that takes its time to show up in ways that the medical… read more here.
Keywords: oncology; member cancer; feel like; like family ... See more keywords
Recognition of fold- and function-specific sites in the ligand-binding domain of the thyroid hormone receptor-like family
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Endocrinology"
DOI: 10.3389/fendo.2022.981090
Abstract: Background The thyroid hormone receptor-like (THR-like) family is the largest transcription factors family belonging to the nuclear receptor superfamily, which directly binds to DNA and regulates the gene expression and thereby controls various metabolic processes… read more here.
Keywords: family; thr like; hormone receptor; like family ... See more keywords