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1
Published in 2019 at "Molecular Oncology"
DOI: 10.1002/1878-0261.12477
Abstract: Polo‐like kinase 1 (Plk1), a master regulator of mitosis and the DNA damage response, is considered to be an intriguing target in the research field of mitotic intervention. The observation that Plk1 is overexpressed in…
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Keywords:
plk1;
like kinase;
volasertib;
polo like ... See more keywords
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1
Published in 2022 at "Hepatology"
DOI: 10.1002/hep.32461
Abstract: Background and Aims: Prognosis of HCC remains poor due to lack of effective therapies. Immune checkpoint inhibitors (ICIs) have delayed response and are only effective in a subset of patients. Treatments that could effectively shrink…
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Keywords:
polo like;
dna;
inhibitor cfi;
like kinase ... See more keywords
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2
Published in 2023 at "Journal of Medical Virology"
DOI: 10.1002/jmv.28610
Abstract: Tick‐borne encephalitis virus (TBEV) is the causative agent of a potentially fatal neurological infection in humans. Investigating virus–host interaction is important for understanding the pathogenesis of TBEV and developing effective antiviral drugs against this virus.…
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Keywords:
borne encephalitis;
like kinase;
encephalitis virus;
mst3 ... See more keywords
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2
Published in 2022 at "Medicinal Research Reviews"
DOI: 10.1002/med.21928
Abstract: Over the past decade, Clk1 has been identified as a promising target for the treatment of various diseases, in which deregulated alternative splicing plays a role. First small molecules targeting Clk1 are in clinical trials…
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Keywords:
like kinase;
overview cdc2;
clk1;
alternative splicing ... See more keywords
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1
Published in 2017 at "Current Genetics"
DOI: 10.1007/s00294-017-0727-2
Abstract: Polo-like kinases are essential cell cycle regulators that are conserved from yeast to humans. Unlike higher eukaryotes, who express multiple Polo-like kinase family members that perform many important functions, budding yeast express only a single…
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Keywords:
dna damage;
like kinase;
cdc5;
polo like ... See more keywords
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0
Published in 2019 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2019.111769
Abstract: Polo-like kinase 1 (Plk1) is a validated target for the treatment of cancer. In this report, by analyzing amino acid residue differences among the ATP-binding pockets of Plk1, Plk2 and Plk3, novel selective Plk1 inhibitors…
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Keywords:
plk1;
like kinase;
plk1 inhibitors;
polo like ... See more keywords
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0
Published in 2018 at "International journal of biological macromolecules"
DOI: 10.1016/j.ijbiomac.2018.05.023
Abstract: Polo-like kinase-1 (PLK-1) plays a key role in cell cycle progression during mitosis. Overexpression/dysfunction of PLK-1 is directly associated with cancerous transformation and has been reported in different cancer types. Here, we employed high throughput…
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Keywords:
like kinase;
kinase;
polo like;
hesperidin ... See more keywords
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Published in 2017 at "Journal of the American College of Cardiology"
DOI: 10.1016/j.jacc.2017.07.162
Abstract: Activin receptor-like kinase 4 (ALK4), a downstream receptor of transforming growth factor-β superfamily, is highly expressed in the mammal heart. We recently reported that ALK4 is upregulated in pressure-overloaded heart and ALK4 haplodeficiency attenuated the…
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Keywords:
pressure overload;
like kinase;
receptor like;
activin receptor ... See more keywords
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1
Published in 2022 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.2c00614
Abstract: Polo-like kinase 1 (PLK1) plays an important role in a variety of cellular functions, including the regulation of mitosis, DNA replication, autophagy, and the epithelial-mesenchymal transition (EMT). PLK1 overexpression is often associated with cell proliferation…
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Keywords:
polo like;
like kinase;
development;
therapy ... See more keywords
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2
Published in 2023 at "ACS infectious diseases"
DOI: 10.1021/acsinfecdis.3c00025
Abstract: Protein kinases have proven to be a very productive class of therapeutic targets, and over 90 inhibitors are currently in clinical use primarily for the treatment of cancer. Repurposing these inhibitors as antimalarials could provide…
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Keywords:
polo like;
human polo;
like kinase;
kinase inhibitors ... See more keywords
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Published in 2018 at "Nature Communications"
DOI: 10.1038/s41467-018-04941-y
Abstract: Tousled-like kinases (TLKs) are required for genome stability and normal development in numerous organisms and have been implicated in breast cancer and intellectual disability. In humans, the similar TLK1 and TLK2 interact with each other…
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Keywords:
tlk2;
like kinase;
kinase;
activation ... See more keywords