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   Articles with "like molecules" as a keyword



High-Throughput Miniaturized Synthesis of PROTAC-Like Molecules.

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recommendations! Published in 2024 at "Small"

DOI: 10.1002/smll.202307215

Abstract: The development of miniaturized high-throughput in situ screening platforms capable of handling the entire process of drug synthesis to final screening is essential for advancing drug discovery in the future. In this study, an approach… read more here.

Keywords: high throughput; protac like; miniaturized synthesis; synthesis ... See more keywords

Using Membrane Partitioning Simulations To Predict Permeability of Forty-Nine Drug-Like Molecules

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recommendations! Published in 2019 at "Journal of chemical information and modeling"

DOI: 10.1021/acs.jcim.8b00744

Abstract: A simple descriptor calculated from molecular dynamics simulations of the membrane partitioning event is found to correlate well with experimental measurements of passive membrane permeation from the high-throughput MDCK-LE assay using a data set of… read more here.

Keywords: like molecules; membrane partitioning; drug; permeability ... See more keywords

Intramolecular Azo Coupling Reaction of Binaphthyl Compounds: Synthesis of Pyrazole-Containing Helicene-Like Molecules.

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recommendations! Published in 2023 at "Organic letters"

DOI: 10.1021/acs.orglett.3c00974

Abstract: A method for accessing pyrazole-containing helicene-like molecules from easily accessible NOBIN derivatives was developed. The reaction proceeded efficiently via diazonium salt intermediates, which provided a series of helicene-like molecular products in yields of 77%-89% regardless… read more here.

Keywords: containing helicene; reaction; helicene like; helicene ... See more keywords
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Synthesis and mesogenic property of new hockey-stick-like molecules

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recommendations! Published in 2017 at "Journal of Information Display"

DOI: 10.1080/15980316.2016.1267045

Abstract: ABSTRACT In this study, new hockey-stick-like molecules were synthesized and characterized. The desired bent-core molecules consist of two arms with different numbers of aromatic rings, each with its own flexible chain with a different number… read more here.

Keywords: hockey stick; like molecules; synthesis mesogenic; new hockey ... See more keywords
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Mucins and Pathogenic Mucin-Like Molecules Are Immunomodulators During Infection and Targets for Diagnostics and Vaccines

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recommendations! Published in 2019 at "Frontiers in Chemistry"

DOI: 10.3389/fchem.2019.00710

Abstract: Mucins and mucin-like molecules are highly O-glycosylated proteins present on the cell surface of mammals and other organisms. These glycoproteins are highly diverse in the apoprotein and glycan cores and play a central role in… read more here.

Keywords: molecules immunomodulators; mucins mucin; like molecules; mucins pathogenic ... See more keywords

The Enhanced Expression of Cruzipain-Like Molecules in the Phytoflagellate Phytomonas serpens Recovered From the Invertebrate and Plant Hosts

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recommendations! Published in 2022 at "Frontiers in Cellular and Infection Microbiology"

DOI: 10.3389/fcimb.2021.819133

Abstract: Phytomonas serpens is a protozoan parasite that alternates its life cycle between two hosts: an invertebrate vector and the tomato fruit. This phytoflagellate is able to synthesize proteins displaying similarity to the cysteine peptidase named… read more here.

Keywords: phytomonas serpens; cruzipain like; expression; expression cruzipain ... See more keywords

Cloning, Expression, and Functional Characterization of FUT1, a Key Gene for Histo-Blood Group Antigens Synthesis in Crassostrea gigas

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recommendations! Published in 2023 at "Current Issues in Molecular Biology"

DOI: 10.3390/cimb45050267

Abstract: Histo-blood group antigens (HBGAs) comprise a family of cell-surface carbohydrates that are considered norovirus-specific binding receptors or ligands. HBGA-like molecules have also been detected in oysters as common norovirus carriers, although the pathway involved in… read more here.

Keywords: gigas; expression; hbga like; histo blood ... See more keywords

Comparison of Selected Crystal Structures of Rod-like Molecules with Acid and Ester Terminal Groups

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recommendations! Published in 2025 at "Crystals"

DOI: 10.3390/cryst15020102

Abstract: The crystal structures of rod-like molecules with nitro-biphenyl or nitro-phenyl end groups and attached n-alkyl units with terminal acid or ester groups are determined by single crystal analysis and their arrangements are compared. The molecules… read more here.

Keywords: comparison selected; rod like; acid ester; like molecules ... See more keywords

Designing Next-Generation Drug-like Molecules for Medicinal Applications

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recommendations! Published in 2023 at "Molecules"

DOI: 10.3390/molecules28041860

Abstract: The development of new drugs/drug candidates for medical treatment remains an exciting but challenging process as only a limited number of synthetic compounds fit well into the discovery and development process after multiple experiments and… read more here.

Keywords: generation drug; drug like; next generation; designing next ... See more keywords