Using Membrane Partitioning Simulations To Predict Permeability of Forty-Nine Drug-Like Molecules
Sign Up to like & getrecommendations! Published in 2019 at "Journal of chemical information and modeling"
DOI: 10.1021/acs.jcim.8b00744
Abstract: A simple descriptor calculated from molecular dynamics simulations of the membrane partitioning event is found to correlate well with experimental measurements of passive membrane permeation from the high-throughput MDCK-LE assay using a data set of… read more here.
Keywords: like molecules; membrane partitioning; drug; permeability ... See more keywords
Intramolecular Azo Coupling Reaction of Binaphthyl Compounds: Synthesis of Pyrazole-Containing Helicene-Like Molecules.
Sign Up to like & getrecommendations! Published in 2023 at "Organic letters"
DOI: 10.1021/acs.orglett.3c00974
Abstract: A method for accessing pyrazole-containing helicene-like molecules from easily accessible NOBIN derivatives was developed. The reaction proceeded efficiently via diazonium salt intermediates, which provided a series of helicene-like molecular products in yields of 77%-89% regardless… read more here.
Keywords: containing helicene; reaction; helicene like; helicene ... See more keywords
Synthesis and mesogenic property of new hockey-stick-like molecules
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Information Display"
DOI: 10.1080/15980316.2016.1267045
Abstract: ABSTRACT In this study, new hockey-stick-like molecules were synthesized and characterized. The desired bent-core molecules consist of two arms with different numbers of aromatic rings, each with its own flexible chain with a different number… read more here.
Keywords: hockey stick; like molecules; synthesis mesogenic; new hockey ... See more keywords
Mucins and Pathogenic Mucin-Like Molecules Are Immunomodulators During Infection and Targets for Diagnostics and Vaccines
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Chemistry"
DOI: 10.3389/fchem.2019.00710
Abstract: Mucins and mucin-like molecules are highly O-glycosylated proteins present on the cell surface of mammals and other organisms. These glycoproteins are highly diverse in the apoprotein and glycan cores and play a central role in… read more here.
Keywords: molecules immunomodulators; mucins mucin; like molecules; mucins pathogenic ... See more keywords
The Enhanced Expression of Cruzipain-Like Molecules in the Phytoflagellate Phytomonas serpens Recovered From the Invertebrate and Plant Hosts
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cellular and Infection Microbiology"
DOI: 10.3389/fcimb.2021.819133
Abstract: Phytomonas serpens is a protozoan parasite that alternates its life cycle between two hosts: an invertebrate vector and the tomato fruit. This phytoflagellate is able to synthesize proteins displaying similarity to the cysteine peptidase named… read more here.
Keywords: phytomonas serpens; cruzipain like; expression; expression cruzipain ... See more keywords
Cloning, Expression, and Functional Characterization of FUT1, a Key Gene for Histo-Blood Group Antigens Synthesis in Crassostrea gigas
Sign Up to like & getrecommendations! Published in 2023 at "Current Issues in Molecular Biology"
DOI: 10.3390/cimb45050267
Abstract: Histo-blood group antigens (HBGAs) comprise a family of cell-surface carbohydrates that are considered norovirus-specific binding receptors or ligands. HBGA-like molecules have also been detected in oysters as common norovirus carriers, although the pathway involved in… read more here.
Keywords: gigas; expression; hbga like; histo blood ... See more keywords
Designing Next-Generation Drug-like Molecules for Medicinal Applications
Sign Up to like & getrecommendations! Published in 2023 at "Molecules"
DOI: 10.3390/molecules28041860
Abstract: The development of new drugs/drug candidates for medical treatment remains an exciting but challenging process as only a limited number of synthetic compounds fit well into the discovery and development process after multiple experiments and… read more here.
Keywords: generation drug; drug like; next generation; designing next ... See more keywords