An integrated and continuous downstream process for microbial virus‐like particle vaccine biomanufacture
Sign Up to like & getrecommendations! Published in 2022 at "Biotechnology and Bioengineering"
DOI: 10.1002/bit.28118
Abstract: In this study, we present the first integrated and continuous downstream process for the production of microbial virus‐like particle vaccines. Modular murine polyomavirus major capsid VP1 with integrated J8 antigen was used as a model… read more here.
Keywords: continuous downstream; process; downstream process; integrated continuous ... See more keywords
Axion-like particle searches at DarkQuest
Sign Up to like & getrecommendations! Published in 2022 at "Journal of High Energy Physics"
DOI: 10.1007/jhep02(2022)036
Abstract: Abstract Axion-like particles (ALPs) interacting with the Standard Model can be abundantly produced in proton beam fixed-target experiments. Looking for their displaced decays is therefore an effective search strategy for ALPs with a mass in… read more here.
Keywords: searches darkquest; like particle; axion like; particle searches ... See more keywords
A split NanoLuc complementation-based human norovirus-like particle entry assay facilitates evaluation of anti-norovirus antibodies in live cells.
Sign Up to like & getrecommendations! Published in 2021 at "Antiviral research"
DOI: 10.1016/j.antiviral.2021.105231
Abstract: Human noroviruses (NoVs) are the most common cause of acute gastroenteritis worldwide. One major obstacle in developing NoV vaccines is the lack of robust cell culture for efficacy evaluation. In this study, we successfully developed… read more here.
Keywords: entry; like particle; entry assay; lgbit ... See more keywords
Virus-like Particle Display of the α-Gal Carbohydrate for Vaccination against Leishmania Infection
Sign Up to like & getrecommendations! Published in 2017 at "ACS Central Science"
DOI: 10.1021/acscentsci.7b00311
Abstract: Secreted and surface-displayed carbohydrates are essential for virulence and viability of many parasites, including for immune system evasion. We have identified the α-Gal trisaccharide epitope on the surface of the protozoan parasites Leishmania infantum and… read more here.
Keywords: like particle; virus like; infection; leishmania infection ... See more keywords
Virus-like particle display of HER2 induces potent anti-cancer responses
Sign Up to like & getrecommendations! Published in 2018 at "Oncoimmunology"
DOI: 10.1080/2162402x.2017.1408749
Abstract: ABSTRACT Overexpression of human epidermal growth factor receptor-2 (HER2) occurs in 20–30% of invasive breast cancers. Monoclonal antibody therapy is effective in treating HER2-driven mammary carcinomas, but its utility is limited by high costs, side… read more here.
Keywords: like particle; potent anti; virus like; cancer ... See more keywords
Virus-like particle vaccine by intranasal vaccination elicits protective immunity against respiratory syncytial viral infection in mice
Sign Up to like & getrecommendations! Published in 2017 at "Acta Biochimica et Biophysica Sinica"
DOI: 10.1093/abbs/gmw118
Abstract: Respiratory syncytial virus (RSV) is a leading cause of lower respiratory infection in infants and children, but there is still no licensed vaccine available. In this report, we developed virus-like particle (VLP) vaccines based on… read more here.
Keywords: like particle; respiratory syncytial; virus like; rsv ... See more keywords
A chikungunya virus–like particle vaccine induces broadly neutralizing and protective antibodies against alphaviruses in humans
Sign Up to like & getrecommendations! Published in 2023 at "Science Translational Medicine"
DOI: 10.1126/scitranslmed.ade8273
Abstract: Chikungunya virus (CHIKV) is a mosquito-transmitted alphavirus that causes epidemics of acute and chronic musculoskeletal disease. Here, we analyzed the human B cell response to a CHIKV-like particle–adjuvanted vaccine (PXVX0317) from samples obtained from a… read more here.
Keywords: broadly neutralizing; chikungunya virus; chikv; vaccine ... See more keywords
An Infrared Dye–Conjugated Virus-like Particle for the Treatment of Primary Uveal Melanoma
Sign Up to like & getrecommendations! Published in 2017 at "Molecular Cancer Therapeutics"
DOI: 10.1158/1535-7163.mct-17-0953
Abstract: The work outlined herein describes AU-011, a novel recombinant papillomavirus-like particle (VLP) drug conjugate and its initial evaluation as a potential treatment for primary uveal melanoma. The VLP is conjugated with a phthalocyanine photosensitizer, IRDye… read more here.
Keywords: like particle; primary uveal; treatment primary; treatment ... See more keywords
An Interlaboratory Study to Identify Potential Visible Protein-Like Particle Standards
Sign Up to like & getrecommendations! Published in 2022 at "AAPS PharmSciTech"
DOI: 10.1208/s12249-022-02457-9
Abstract: Visible protein-like particle standards may improve visual inspection and/or appearance testing practices used in the biotechnology industry. They may improve assay performance resulting in better alignment and more standardized training among different companies. The National… read more here.
Keywords: interlaboratory study; particle standards; protein like; visible protein ... See more keywords
Zika virus-like particle (VLP) based vaccine
Sign Up to like & getrecommendations! Published in 2017 at "PLoS Neglected Tropical Diseases"
DOI: 10.1371/journal.pntd.0005608
Abstract: The newly emerged mosquito-borne Zika virus poses a major public challenge due to its ability to cause significant birth defects and neurological disorders. The impact of sexual transmission is unclear but raises further concerns about… read more here.
Keywords: like particle; vaccine; virus like; zika virus ... See more keywords
Universal protection against influenza viruses by multi-subtype neuraminidase and M2 ectodomain virus-like particle
Sign Up to like & getrecommendations! Published in 2022 at "PLoS Pathogens"
DOI: 10.1371/journal.ppat.1010755
Abstract: Annual influenza vaccination is recommended to update the variable hemagglutinin antigens. Here, we first designed a virus-like particle (VLP) displaying consensus multi-neuraminidase (NA) subtypes (cN1, cN2, B cNA) and M2 ectodomain (M2e) tandem repeat (m-cNA-M2e… read more here.
Keywords: cna m2e; vlp; influenza; virus like ... See more keywords