Branched short elastin‐like peptides with temperature responsiveness obtained by EDTA‐mediated multimerization
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Peptide Science"
DOI: 10.1002/psc.3449
Abstract: Elastin‐like peptides (ELPs) exhibit a reversible phase transition, known as coacervation, triggered by temperature changes. This property makes them useful as stimuli‐responsive molecular materials for various applications. Among ELPs, short peptide chain lengths have some… read more here.
Keywords: like peptides; elastin like; temperature; multimerization ... See more keywords
Role of glucagon-like peptides in inflammatory bowel diseases—current knowledge and future perspectives
Sign Up to like & getrecommendations! Published in 2019 at "Naunyn-Schmiedeberg's Archives of Pharmacology"
DOI: 10.1007/s00210-019-01698-z
Abstract: Inflammatory bowel diseases (IBD), including Crohn’s disease (CD) and ulcerative colitis (UC), are chronic, relapsing, intestinal inflammatory disorders with complex and yet unrevealed pathogenesis in which genetic, immunological, and environmental factors play a role. Nowadays,… read more here.
Keywords: glucagon like; inflammatory bowel; current knowledge; bowel diseases ... See more keywords
Identification of Rubisco anxiolytic-like peptides (rALPs) by comprehensive analysis of spinach green leaf protein digest.
Sign Up to like & getrecommendations! Published in 2018 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2018.09.195
Abstract: Rubisco, an enzyme for photosynthetic carbon dioxide fixation, is a major green leaf protein and known as the most abundant protein on the Earth. We found that Rubisco digested mimicking gastrointestinal enzymatic conditions exhibited anxiolytic-like… read more here.
Keywords: protein; ralp ralp; ralp; green leaf ... See more keywords
Increased Akt signaling in the fat body of Anopheles stephensi extends lifespan and increases lifetime fecundity through modulation of insulin-like peptides.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of insect physiology"
DOI: 10.1016/j.jinsphys.2019.103932
Abstract: Insulin-like peptides (ILPs) and the insulin/insulin-like growth factor 1 signaling (IIS) cascade regulate numerous physiological functions, including lifespan, reproduction, immunity, and metabolism, in diverse eukaryotes. We previously demonstrated that in female Anopheles stephensi and Aedes… read more here.
Keywords: fat body; lifetime fecundity; insulin like; like peptides ... See more keywords
Isolation and characterization of FMRFamide-like peptides in the venoms of solitary sphecid wasps
Sign Up to like & getrecommendations! Published in 2021 at "Peptides"
DOI: 10.1016/j.peptides.2021.170575
Abstract: Purification of small peptide components in the venoms of the solitary sphecid wasps, Sphex argentatus argentatus and Isodontia harmandi, led to the isolation of several major peptides. Analysis of MS/MS spectra by MALDI-TOF/TOF revealed the… read more here.
Keywords: sphecid wasps; fmrfamide like; solitary sphecid; venoms solitary ... See more keywords
Precision Loading and Delivery of Molecular Cargo by Size-Controlled Coacervation of Gold Nanoparticles Functionalized with Elastin-like Peptides.
Sign Up to like & getrecommendations! Published in 2024 at "Biomacromolecules"
DOI: 10.1021/acs.biomac.3c01312
Abstract: Thermoresponsive elastin-like peptides (ELPs) have been extensively investigated in biotechnology and medicine, but little attention has been paid to the process by which coacervation causes ELP-decorated particles to aggregate. Using gold nanoparticles (AuNPs) functionalized with… read more here.
Keywords: like peptides; size; molecular cargo; elastin like ... See more keywords
Structure of Designer Antibody-like Peptides Binding to the Human C5a with Potential to Modulate the C5a Receptor Signaling.
Sign Up to like & getrecommendations! Published in 2024 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.4c00961
Abstract: C5a is an integral glycoprotein of the complement system that plays an important role in inflammation and immunity. The physiological concentration of C5a is observed to be elevated under various immunoinflammatory pathophysiological conditions in humans.… read more here.
Keywords: antibody like; c5a; like peptides; designer antibody ... See more keywords
Exploration of the hierarchical assembly space of collagen-like peptides beyond the triple helix
Sign Up to like & getrecommendations! Published in 2024 at "Nature Communications"
DOI: 10.1038/s41467-024-54560-z
Abstract: The de novo design of self-assembling peptides has garnered significant attention in scientific research. While alpha-helical assemblies have been extensively studied, exploration of polyproline type II helices, such as those found in collagen, remains relatively… read more here.
Keywords: like peptides; collagen; exploration; beyond triple ... See more keywords
Insulin signaling in Drosophila melanogaster mediates Aβ toxicity
Sign Up to like & getrecommendations! Published in 2019 at "Communications Biology"
DOI: 10.1038/s42003-018-0253-x
Abstract: Alzheimer’s disease (AD) and diabetes are clinically positively correlated. However, the connection between them is not clarified. Here, using Drosophila as a model system, we show that reducing insulin signaling can effectively suppress the toxicity… read more here.
Keywords: insulin; insulin like; toxicity; signaling drosophila ... See more keywords
Reinforcement learning-driven exploration of peptide space: accelerating generation of drug-like peptides
Sign Up to like & getrecommendations! Published in 2024 at "Briefings in Bioinformatics"
DOI: 10.1093/bib/bbae444
Abstract: Abstract Using amino acid residues in peptide generation has solved several key problems, including precise control of amino acid sequence order, customized peptides for property modification, and large-scale peptide synthesis. Proteins contain unknown amino acid… read more here.
Keywords: like peptides; generation; drug like; drug ... See more keywords
Sublethal concentration of λ‐cyhalothrin inhibits insulin‐like peptides and leads to reproductive toxicity in Chrysoperla sinica
Sign Up to like & getrecommendations! Published in 2024 at "Insect Science"
DOI: 10.1111/1744-7917.13463
Abstract: Insulin‐like peptides (ILPs) act as crucial reproductive neuropeptides in insects, regulating insect reproduction through the insulin signaling pathway (ISP). Our previous studies have found that the sublethal concentrations (LC1 and LC10) of lambda‐cyhalothrin (λCy) could… read more here.
Keywords: insulin like; chrysoperla sinica; reproductive toxicity; like peptides ... See more keywords