Matrix‐Embedded Endothelial Cells Attain a Progenitor‐Like Phenotype
Sign Up to like & getrecommendations! Published in 2017 at "Advanced Biosystems"
DOI: 10.1002/adbi.201700057
Abstract: Culture of endothelial cells (ECs) embedded in 3D scaffolds of denatured collagen has shown tremendous therapeutic potential in clinical trials of tissue repair. It is postulated that these matrix‐embedded ECs (MEECs) attain a differential phenotype… read more here.
Keywords: phenotype; matrix embedded; expression; endothelial cells ... See more keywords
Gemcitabine‐induced epithelial‐mesenchymal transition‐like changes sustain chemoresistance of pancreatic cancer cells of mesenchymal‐like phenotype
Sign Up to like & getrecommendations! Published in 2019 at "Molecular Carcinogenesis"
DOI: 10.1002/mc.23090
Abstract: Growing body of evidence suggests that epithelial‐mesenchymal transition (EMT) is a critical process in tumor progression and chemoresistance in pancreatic cancer (PC). The aim of this study was to analyze the role of EMT‐like changes… read more here.
Keywords: phenotype; chemoresistance; cells mesenchymal; pancreatic cancer ... See more keywords
Holmes Tremor‐Like Phenotype in DYT1 Dystonia
Sign Up to like & getrecommendations! Published in 2018 at "Movement Disorders Clinical Practice"
DOI: 10.1002/mdc3.12585
Abstract: Fil: Rodriguez Quiroga, Sergio Alejandro. Gobierno de la Ciudad de Buenos Aires. Hospital General de Agudos "Ramos Mejia"; Argentina read more here.
Keywords: holmes tremor; dyt1 dystonia; phenotype dyt1; tremor like ... See more keywords
PSP‐Like Phenotype in Genetically Confirmed SCA12
Sign Up to like & getrecommendations! Published in 2022 at "Movement Disorders Clinical Practice"
DOI: 10.1002/mdc3.13590
Abstract: Spinocerebellar ataxia type 12 (SCA12) is an autosomal domi-nant cerebellar ataxia caused by CAG repeat expansions in the protein phosphatase 2 regulatory subunit B beta (PPP2R2B) gene in chromosome 5q. 1 The prevalence of SCA12… read more here.
Keywords: psp like; sca12; confirmed sca12; genetically confirmed ... See more keywords
H3K9me2 regulation of BDNF expression in the hippocampus and medial prefrontal cortex is involved in the depressive-like phenotype induced by maternal separation in male rats.
Sign Up to like & getrecommendations! Published in 2021 at "Psychopharmacology"
DOI: 10.1007/s00213-021-05896-7
Abstract: BACKGROUND Early life stress (ELS) induces a depressive-like phenotype and increases the risk of depression. Brain-derived neurotrophic factor (BDNF) has been confirmed to be involved in the pathophysiology of depression. However, the mechanism by which… read more here.
Keywords: expression hippocampus; depressive like; expression; bdnf ... See more keywords
Brain-derived neurotrophic factor-TrkB signaling in the medial prefrontal cortex plays a role in the anhedonia-like phenotype after spared nerve injury
Sign Up to like & getrecommendations! Published in 2018 at "European Archives of Psychiatry and Clinical Neuroscience"
DOI: 10.1007/s00406-018-0909-z
Abstract: Although depressive symptoms including anhedonia (i.e., loss of pleasure) frequently accompany pain, little is known about the risk factors contributing to individual differences in pain-induced anhedonia. In this study, we examined if signaling of brain-derived… read more here.
Keywords: pain induced; trkb signaling; anhedonia like; like phenotype ... See more keywords
Heterozygosity for ARID2 loss-of-function mutations in individuals with a Coffin–Siris syndrome-like phenotype
Sign Up to like & getrecommendations! Published in 2017 at "Human Genetics"
DOI: 10.1007/s00439-017-1757-z
Abstract: Chromatin remodeling is a complex process shaping the nucleosome landscape, thereby regulating the accessibility of transcription factors to regulatory regions of target genes and ultimately managing gene expression. The SWI/SNF (switch/sucrose nonfermentable) complex remodels the… read more here.
Keywords: coffin siris; mutations individuals; swi snf; gene ... See more keywords
Schlafen-11 expression is associated with immune signatures and basal-like phenotype in breast cancer
Sign Up to like & getrecommendations! Published in 2019 at "Breast Cancer Research and Treatment"
DOI: 10.1007/s10549-019-05313-w
Abstract: Breast cancer (BC) is a heterogeneous disorder, with variable response to systemic chemotherapy. Likewise, BC shows highly complex immune activation patterns, only in part reflecting classical histopathological subtyping. Schlafen-11 (SLFN11) is a nuclear protein we… read more here.
Keywords: breast cancer; activation; cancer; basal like ... See more keywords
Urolithin A Induces Brown-like Phenotype in 3T3-L1 White Adipocytes via β3-adrenergic Receptor-p38 MAPK Signaling Pathway
Sign Up to like & getrecommendations! Published in 2020 at "Biotechnology and Bioprocess Engineering"
DOI: 10.1007/s12257-020-0149-8
Abstract: Recently, pharmacological activation of thermogenesis in brown fat and induction of white fat browning (beiging) have been considered as promising strategies in the development of anti-obesity drugs. During the screening of natural compounds that may… read more here.
Keywords: brown like; white adipocytes; 3t3 white; phenotype 3t3 ... See more keywords
Chronic Intermittent Hypoxia Triggers a Senescence-like Phenotype in Human White Preadipocytes
Sign Up to like & getrecommendations! Published in 2020 at "Scientific Reports"
DOI: 10.1038/s41598-020-63761-7
Abstract: Obstructive sleep apnea (OSA) is a common sleep disorder associated with obesity. Emerging evidence suggest that OSA increases the risk of cardiovascular morbidity and mortality partly via accelerating the process of cellular aging. Thus, we… read more here.
Keywords: human white; senescence like; intermittent hypoxia; like phenotype ... See more keywords
‘Leukodystrophy-Like’ Phenotype in anti-MOG antibody-associated disorders
Sign Up to like & getrecommendations! Published in 2022 at "Neuropediatrics"
DOI: 10.1055/a-1740-9649
Abstract: ). A 7-year-old girl developed sudden-onset right-faciobrachial hemiparesis after 3-month period of progressive abnormal behavior and academic impairment without encephalopathy. Brain MRI at diagnosis showed an extensive and confluent bilateral white matter involvement and gadolinium… read more here.
Keywords: leukodystrophy like; anti mog; mog antibody; phenotype anti ... See more keywords