Hydra-Elastin-like Polypeptides Increase Rapamycin Potency When Targeting Cell Surface GRP78.
Sign Up to like & getrecommendations! Published in 2022 at "Biomacromolecules"
DOI: 10.1021/acs.biomac.2c00048
Abstract: Rapalogues are powerful therapeutic modalities for breast cancer; however, they suffer from low solubility and dose-limiting side effects. To overcome these challenges, we developed a long-circulating multiheaded drug carrier called 5FA, which contains rapamycin-binding domains… read more here.
Keywords: like polypeptides; cell surface; carrier; elastin like ... See more keywords
Sequence Context and Complex Hofmeister Salt Interactions Dictate Phase Separation Propensity of Resilin-like Polypeptides.
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DOI: 10.1021/acs.biomac.2c01027
Abstract: Resilin is an elastic material found in insects with exceptional durability, resilience, and extensibility, making it a promising biomaterial for tissue engineering. The monomeric precursor, pro-resilin, undergoes thermo-responsive self-assembly through liquid-liquid phase separation (LLPS). Understanding… read more here.
Keywords: phase separation; sequence; resilin like; like polypeptides ... See more keywords
Sequence Control of the Self-Assembly of Elastin-Like Polypeptides into Hydrogels with Bespoke Viscoelastic and Structural Properties
Sign Up to like & getrecommendations! Published in 2022 at "Biomacromolecules"
DOI: 10.1021/acs.biomac.2c01405
Abstract: The biofabrication of structural proteins with controllable properties via amino acid sequence design is interesting for biomedicine and biotechnology, yet a complete framework that connects amino acid sequence to material properties is unavailable, despite great… read more here.
Keywords: structural properties; control; sequence; elastin like ... See more keywords
Rapid and simple purification of elastin-like polypeptides directly from whole cells and cell lysates by organic solvent extraction.
Sign Up to like & getrecommendations! Published in 2018 at "Biomaterials science"
DOI: 10.1039/c8bm00124c
Abstract: Elastin-like polypeptides (ELP) are a well-known class of proteins that are being increasingly utilized in a variety of biomedical applications, due to their beneficial physicochemical properties. A unifying feature of ELP is their demonstration of… read more here.
Keywords: extraction; like polypeptides; elp; elastin like ... See more keywords
Globule and fiber formation with elastin-like polypeptides: a balance of coacervation and crosslinking.
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DOI: 10.1039/d2sm00049k
Abstract: Elastic fiber assembly is a complex process that requires the coacervation and cross-linking of the protein building block tropoelastin. To date, the order, timing, and interplay of coacervation and crosslinking is not completely understood, despite… read more here.
Keywords: formation; coacervation crosslinking; coacervation; elastin like ... See more keywords
Elastin-like polypeptides: the power of design for smart cell encapsulation
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DOI: 10.1080/17425247.2016.1206072
Abstract: ABSTRACT Introduction: Cell encapsulation technology is still a challenging issue. Innovative methodologies such as additive manufacturing, and alternative bioprocesses, such as cell therapeutic delivery, where cell encapsulation is a key tool are rapidly gaining importance… read more here.
Keywords: medicine; like polypeptides; elastin like; cell encapsulation ... See more keywords
Engineered elastin-like polypeptides: An efficient platform for enhanced cancer treatment
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2022.1113079
Abstract: Drug delivery systems (DDSs) have recently gained widespread attention for improving drug loading and delivery efficiency in treating many cancers. Elastin-like polypeptides (ELPs) are synthetic peptides derived from a precursor of elastin (tropoelastin), reserving similar… read more here.
Keywords: elastin like; like polypeptides; cancer treatment; delivery ... See more keywords