LncRNA DGCR5 contributes to CSC‐like properties via modulating miR‐330‐5p/CD44 in NSCLC
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.26590
Abstract: Non‐coding RNAs can exert significant roles various cancers, including NSCLC. Previously, we indicated that lncRNA DGCR5 can promote lung cancer progression through inhibiting hsa‐mir‐22‐3p. In our current study, we investigated the role of DGCR5 in… read more here.
Keywords: nsclc; csc like; dgcr5; cd44 ... See more keywords
In Vivo Behavior of Ultrasmall Spherical Nucleic Acids.
Sign Up to like & getrecommendations! Published in 2023 at "Small"
DOI: 10.1002/smll.202300097
Abstract: The biological properties of spherical nucleic acids (SNAs) are largely independent of nanoparticle core identity but significantly affected by oligonucleotide surface density. Additionally, the payload-to-carrier (i.e., DNA-to-nanoparticle) mass ratio of SNAs is inversely proportional to… read more here.
Keywords: nanoparticle; like properties; vivo behavior; spherical nucleic ... See more keywords
The selective 5-HT1A receptor biased agonists, F15599 and F13714, show antidepressant-like properties after a single administration in the mouse model of unpredictable chronic mild stress
Sign Up to like & getrecommendations! Published in 2021 at "Psychopharmacology"
DOI: 10.1007/s00213-021-05849-0
Abstract: Rationale The prevalence of depression is ever-increasing throughout the population. However, available treatments are ineffective in around one-third of patients and there is a need for more effective and safer drugs. Objectives The antidepressant-like and… read more here.
Keywords: agonists f15599; f15599 f13714; unpredictable chronic; like properties ... See more keywords
Prion-like properties of disease-relevant proteins in amyotrophic lateral sclerosis
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Neural Transmission"
DOI: 10.1007/s00702-018-1851-y
Abstract: The hallmark of age-related neurodegenerative diseases is the appearance of cellular protein deposits and spreading of this pathology throughout the central nervous system. Growing evidence has shown the involvement and critical role of proteins with… read more here.
Keywords: properties disease; prion like; disease relevant; pathology ... See more keywords
Phosphofructokinase Relocalizes into Subcellular Compartments with Liquid-like Properties In Vivo.
Sign Up to like & getrecommendations! Published in 2020 at "Biophysical journal"
DOI: 10.1016/j.bpj.2020.08.002
Abstract: Although much is known about the biochemical regulation of glycolytic enzymes, less is understood about how they are organized inside cells. We systematically examine the dynamic subcellular localization of glycolytic protein phosphofructokinase-1/PFK-1.1 in Caenorhabditis elegans.… read more here.
Keywords: subcellular compartments; pfk condensates; phosphofructokinase; pfk ... See more keywords
Prion-like properties of assembled TDP-43
Sign Up to like & getrecommendations! Published in 2020 at "Current Opinion in Neurobiology"
DOI: 10.1016/j.conb.2019.11.018
Abstract: A neuropathological hallmark of most neurodegenerative diseases is the appearance of characteristic inclusions composed of misfolded proteins in brains of patients. Increasing evidence shows that aggregation-prone proteins such as tau, α-synuclein and TDP-43 are accumulated… read more here.
Keywords: prion like; prion; protein aggregates; properties assembled ... See more keywords
Prion-like properties of Tau assemblies
Sign Up to like & getrecommendations! Published in 2020 at "Current Opinion in Neurobiology"
DOI: 10.1016/j.conb.2019.11.022
Abstract: Emerging evidences linking pathological mechanisms of prions and tauopathies are accumulating. However, Tau assemblies do not yet fulfill all the criteria of prions. Here, we review recent data pointing similarities between prions and tauopathies and… read more here.
Keywords: tau assemblies; properties tau; prion like; neurobiology ... See more keywords
Drug-like properties and complete physicochemical profile of pyrazine‑2‑amidoxime: A combined multi-experimental and computational studies
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Molecular Liquids"
DOI: 10.1016/j.molliq.2018.11.147
Abstract: Abstract Pyrazine‑2‑amidoxime (PAOX) is a prototypical sp2-hybridized amidoxime. Although, we described first time in details PAOX structure in solid state, the profile of PAOX behavior in aqueous solution still needs to be improved. While, acid-base… read more here.
Keywords: pyrazine amidoxime; drug like; profile; like properties ... See more keywords
Conversion of a PROTAC Mutant Huntingtin Degrader into Small-Molecule Hydrophobic Tags Focusing on Drug-like Properties.
Sign Up to like & getrecommendations! Published in 2022 at "ACS medicinal chemistry letters"
DOI: 10.1021/acsmedchemlett.1c00500.s002
Abstract: The onset of neurodegenerative disorders (NDs), such as Alzheimer's disease, is associated with the accumulation of aggregates of misfolded proteins. We previously showed that chemical knockdown of ND-related aggregation-prone proteins can be achieved by proteolysis… read more here.
Keywords: like properties; hydrophobic tags; drug like; mutant huntingtin ... See more keywords
Acrylamide Functional Group Incorporation Improves Drug-like Properties: An Example with EGFR Inhibitors.
Sign Up to like & getrecommendations! Published in 2019 at "ACS medicinal chemistry letters"
DOI: 10.1021/acsmedchemlett.8b00270
Abstract: We demonstrate that the acrylamide group can be used to improve the drug-like properties of potential drug candidates. In the EGFR inhibitor development, both the solubility and membrane permeability properties of compounds 6a and 7,… read more here.
Keywords: acrylamide functional; group; drug; incorporation ... See more keywords
Prion-like properties of the mutant huntingtin protein in living organisms: the evidence and the relevance
Sign Up to like & getrecommendations! Published in 2021 at "Molecular Psychiatry"
DOI: 10.1038/s41380-021-01350-4
Abstract: If theories postulating that pathological proteins associated with neurodegenerative disorders behave similarly to prions were initially viewed with reluctance, it is now well-accepted that this occurs in several disease contexts. Notably, it has been reported… read more here.
Keywords: properties mutant; huntingtin protein; prion like; prion ... See more keywords