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   Articles with "like protease" as a keyword



The S2 Pocket Governs the Genus‐Specific Substrate Selectivity of Coronavirus 3C‐Like Protease

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recommendations! Published in 2024 at "Advanced Science"

DOI: 10.1002/advs.202407766

Abstract: Coronavirus 3C‐like protease (CoV 3CLpro) is essential for viral replication, providing an attractive target for monitoring the evolution of CoV and developing anti‐CoV drugs. Here, the substrate‐binding modes of 3CLpros from four CoV genera are… read more here.

Keywords: like protease; coronavirus like; pocket; genus specific ... See more keywords

SARS‐CoV‐2 Papain‐Like Protease: Structure, Function and Inhibition

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recommendations! Published in 2022 at "Chembiochem"

DOI: 10.1002/cbic.202200327

Abstract: Emerging variants of SARS‐CoV‐2 and potential novel epidemic coronaviruses underline the importance of investigating various viral proteins as potential drug targets. The papain‐like protease of coronaviruses has been less explored than other viral proteins; however,… read more here.

Keywords: like protease; papain like; structure function; sars cov ... See more keywords

Mass spectrometric assays reveal discrepancies in inhibition profiles for the SARS-CoV-2 papain-like protease.

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recommendations! Published in 2022 at "ChemMedChem"

DOI: 10.1002/cmdc.202200016

Abstract: The two SARS-CoV-2 proteases, i.e. the main protease (M pro ) and the papain-like protease (PL pro ), which hydrolyze the viral polypeptide chain giving functional non-structural proteins, are essential for viral replication and are… read more here.

Keywords: pro inhibitors; sars cov; mass; papain like ... See more keywords
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Sulforaphane is a reversible covalent inhibitor of 3‐chymotrypsin‐like protease of SARS‐CoV‐2

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recommendations! Published in 2023 at "Journal of Medical Virology"

DOI: 10.1002/jmv.28609

Abstract: The ongoing pandemic of coronavirus disease 2019 (COVID‐19) caused by severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) has posed a major public health threat worldwide and emphasizes an urgent need for effective therapeutics. Recently, Ordonez… read more here.

Keywords: sulforaphane; inhibitor; like protease; chymotrypsin like ... See more keywords

Papain‐Like Protease of SARS‐CoV‐2 Induces Intestinal Inflammation via the ISG15 Pathway: Identification of Natural Compound Inhibitors

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recommendations! Published in 2025 at "Journal of Medical Virology"

DOI: 10.1002/jmv.70448

Abstract: The SARS‐CoV‐2 papain‐like protease (PLpro) is a multifunctional viral protein that facilitates viral assembly and disrupts host immune responses by removing interferon‐stimulated gene 15 (ISG15) modifications from target proteins. However, the mechanisms by which PLpro‐mediated… read more here.

Keywords: sars cov; intestinal inflammation; like protease; papain like ... See more keywords

In Silico Analysis of Inhibiting Papain-like Protease from SARS-CoV-2 by Using Plant-Derived Peptides

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recommendations! Published in 2022 at "International Journal of Peptide Research and Therapeutics"

DOI: 10.1007/s10989-021-10331-8

Abstract: SARS-CoV-2 is a corona virus that has been the cause for one of the deadliest pandemics of history, started since 2019. Suppressing the activity of the critical enzymes in the SARS-CoV-2 could potentially inhibit a… read more here.

Keywords: papain like; plant derived; like protease; sars cov ... See more keywords

Exploring naphthyl derivatives as SARS-CoV papain-like protease (PLpro) inhibitors and its implications in COVID-19 drug discovery

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recommendations! Published in 2021 at "Molecular Diversity"

DOI: 10.1007/s11030-021-10198-3

Abstract: Abstract Novel coronavirus disease 2019 (COVID-19) emerges as a serious threat to public health globally. The rapid spreading of COVID-19, caused by severe acute respiratory syndrome (SARS) coronavirus 2 (SARS-CoV-2), proclaimed the multitude of applied… read more here.

Keywords: naphthyl derivatives; like protease; papain like; sars cov ... See more keywords

Porcine epidemic diarrhea virus papain-like protease 2 can be noncompetitively inhibited by 6-thioguanine

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recommendations! Published in 2018 at "Antiviral Research"

DOI: 10.1016/j.antiviral.2018.08.011

Abstract: Abstract Porcine epidemic diarrhea virus (PEDV) is a coronavirus (CoV) discovered in the 1970s that infects the intestinal tract of pigs, resulting in diarrhea and vomiting. It can cause extreme dehydration and death in neonatal… read more here.

Keywords: porcine epidemic; epidemic diarrhea; like protease; papain like ... See more keywords

Merbromin is a mixed-type inhibitor of 3-chyomotrypsin like protease of SARS-CoV-2

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recommendations! Published in 2021 at "Biochemical and Biophysical Research Communications"

DOI: 10.1016/j.bbrc.2021.12.108

Abstract: 3-chyomotrypsin like protease (3CLpro) has been considered as a promising target for developing anti-SARS-CoV-2 drugs. Herein, about 6000 compounds were analyzed by high-throughput screening using enzyme activity model, and Merbromin, an antibacterial agent, was identified… read more here.

Keywords: merbromin mixed; sars cov; inhibitor; like protease ... See more keywords

A novel rennin like protease from Lactobacillus plantarum 1.13 isolated from Indonesian fermented meat (Bakasam)

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recommendations! Published in 2020 at "Biocatalysis and agricultural biotechnology"

DOI: 10.1016/j.bcab.2020.101818

Abstract: Abstract Cheese processing requires rennin during curdling process. A rennin like protease was extracted from Lactobacillus plantarum 1.13 isolated from Bakasam (traditional fermented meat) and characterized. The novel rennin like protease was purified by ammonium… read more here.

Keywords: rennin; like protease; plantarum isolated; rennin like ... See more keywords

Development of potent and selective inhibitors targeting the papain-like protease of SARS-CoV-2

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recommendations! Published in 2021 at "Cell Chemical Biology"

DOI: 10.1016/j.chembiol.2021.04.020

Abstract: The COVID-19 pandemic has been disastrous to society and effective drugs are urgent needed. The papain-like protease domain (PLpro) of SARS-CoV-2 (SCoV2) is indispensable for viral replication and represents a putative target for pharmacological intervention.… read more here.

Keywords: development potent; potent selective; like protease; papain like ... See more keywords