SARS‐CoV‐2 Papain‐Like Protease: Structure, Function and Inhibition
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DOI: 10.1002/cbic.202200327
Abstract: Emerging variants of SARS‐CoV‐2 and potential novel epidemic coronaviruses underline the importance of investigating various viral proteins as potential drug targets. The papain‐like protease of coronaviruses has been less explored than other viral proteins; however,… read more here.
Keywords: like protease; papain like; structure function; sars cov ... See more keywords
Mass spectrometric assays reveal discrepancies in inhibition profiles for the SARS-CoV-2 papain-like protease.
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DOI: 10.1002/cmdc.202200016
Abstract: The two SARS-CoV-2 proteases, i.e. the main protease (M pro ) and the papain-like protease (PL pro ), which hydrolyze the viral polypeptide chain giving functional non-structural proteins, are essential for viral replication and are… read more here.
Keywords: pro inhibitors; sars cov; mass; papain like ... See more keywords
Sulforaphane is a reversible covalent inhibitor of 3‐chymotrypsin‐like protease of SARS‐CoV‐2
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Medical Virology"
DOI: 10.1002/jmv.28609
Abstract: The ongoing pandemic of coronavirus disease 2019 (COVID‐19) caused by severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) has posed a major public health threat worldwide and emphasizes an urgent need for effective therapeutics. Recently, Ordonez… read more here.
Keywords: sulforaphane; inhibitor; like protease; chymotrypsin like ... See more keywords
In Silico Analysis of Inhibiting Papain-like Protease from SARS-CoV-2 by Using Plant-Derived Peptides
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DOI: 10.1007/s10989-021-10331-8
Abstract: SARS-CoV-2 is a corona virus that has been the cause for one of the deadliest pandemics of history, started since 2019. Suppressing the activity of the critical enzymes in the SARS-CoV-2 could potentially inhibit a… read more here.
Keywords: papain like; plant derived; like protease; sars cov ... See more keywords
Exploring naphthyl derivatives as SARS-CoV papain-like protease (PLpro) inhibitors and its implications in COVID-19 drug discovery
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DOI: 10.1007/s11030-021-10198-3
Abstract: Abstract Novel coronavirus disease 2019 (COVID-19) emerges as a serious threat to public health globally. The rapid spreading of COVID-19, caused by severe acute respiratory syndrome (SARS) coronavirus 2 (SARS-CoV-2), proclaimed the multitude of applied… read more here.
Keywords: naphthyl derivatives; like protease; papain like; sars cov ... See more keywords
Porcine epidemic diarrhea virus papain-like protease 2 can be noncompetitively inhibited by 6-thioguanine
Sign Up to like & getrecommendations! Published in 2018 at "Antiviral Research"
DOI: 10.1016/j.antiviral.2018.08.011
Abstract: Abstract Porcine epidemic diarrhea virus (PEDV) is a coronavirus (CoV) discovered in the 1970s that infects the intestinal tract of pigs, resulting in diarrhea and vomiting. It can cause extreme dehydration and death in neonatal… read more here.
Keywords: porcine epidemic; epidemic diarrhea; like protease; papain like ... See more keywords
Merbromin is a mixed-type inhibitor of 3-chyomotrypsin like protease of SARS-CoV-2
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DOI: 10.1016/j.bbrc.2021.12.108
Abstract: 3-chyomotrypsin like protease (3CLpro) has been considered as a promising target for developing anti-SARS-CoV-2 drugs. Herein, about 6000 compounds were analyzed by high-throughput screening using enzyme activity model, and Merbromin, an antibacterial agent, was identified… read more here.
Keywords: merbromin mixed; sars cov; inhibitor; like protease ... See more keywords
A novel rennin like protease from Lactobacillus plantarum 1.13 isolated from Indonesian fermented meat (Bakasam)
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DOI: 10.1016/j.bcab.2020.101818
Abstract: Abstract Cheese processing requires rennin during curdling process. A rennin like protease was extracted from Lactobacillus plantarum 1.13 isolated from Bakasam (traditional fermented meat) and characterized. The novel rennin like protease was purified by ammonium… read more here.
Keywords: rennin; like protease; plantarum isolated; rennin like ... See more keywords
Development of potent and selective inhibitors targeting the papain-like protease of SARS-CoV-2
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DOI: 10.1016/j.chembiol.2021.04.020
Abstract: The COVID-19 pandemic has been disastrous to society and effective drugs are urgent needed. The papain-like protease domain (PLpro) of SARS-CoV-2 (SCoV2) is indispensable for viral replication and represents a putative target for pharmacological intervention.… read more here.
Keywords: development potent; potent selective; like protease; papain like ... See more keywords
Targeting multiple conformations of SARS-CoV2 Papain-Like Protease for drug repositioning: An in-silico study
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DOI: 10.1016/j.compbiomed.2021.104295
Abstract: Papain-Like Protease (PLpro) is a key protein for SARS-CoV-2 viral replication which is the cause of the emerging COVID-19 pandemic. Targeting PLpro can suppress viral replication and provide treatment options for COVID-19. Due to the… read more here.
Keywords: drug repositioning; targeting multiple; multiple conformations; like protease ... See more keywords
The development of Coronavirus 3C-Like protease (3CLpro) inhibitors from 2010 to 2020
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DOI: 10.1016/j.ejmech.2020.112711
Abstract: Abstract This review fully describes the coronavirus 3CLpro peptidomimetic inhibitors and nonpeptidic small molecule inhibitors developed from 2010 to 2020. Specifically, the structural characteristics, binding modes and SARs of these 3CLpro inhibitors are expounded in… read more here.
Keywords: 2010 2020; development coronavirus; 3clpro inhibitors; coronavirus like ... See more keywords