Dual Functioned Hexapeptide-Coated Lipid-Core Nanomicelles Suppress Toll-Like Receptor-Mediated Inflammatory Responses through Endotoxin Scavenging and Endosomal pH Modulation.
Sign Up to like & getrecommendations! Published in 2023 at "Advanced science"
DOI: 10.1002/advs.202301230
Abstract: Excessive activation of Toll-like receptor (TLR) signaling pathways and the circulating endotoxin are key players in the pathogenesis of many acute and chronic inflammatory diseases. Regulation of TLR-mediated inflammatory responses by bioactive nanodevices represents a promising… read more here.
Keywords: core nanomicelles; like receptor; toll like; lipid core ... See more keywords
Genetic variants in toll‐like receptor 4 are associated with lack of steroid‐responsiveness in pediatric ITP patients
Sign Up to like & getrecommendations! Published in 2020 at "American Journal of Hematology"
DOI: 10.1002/ajh.25716
Abstract: Although the most common front‐line therapies for immune thrombocytopenia (ITP) have been in use for decades, it is still not possible to predict an individual patient's clinical course and response to therapy. Patients are managed… read more here.
Keywords: toll like; response; itp patients; like receptor ... See more keywords
Toll‐like Receptor 4 Signaling in Neurons Enhances Calcium‐Permeable AMPA Receptor Currents and Drives Post‐Traumatic Epileptogenesis
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DOI: 10.1002/ana.25698
Abstract: Traumatic brain injury is a major risk factor for acquired epilepsies, and understanding the mechanisms underlying the early pathophysiology could yield viable therapeutic targets. Growing evidence indicates a role for inflammatory signaling in modifying neuronal… read more here.
Keywords: toll like; epileptogenesis; like receptor; receptor signaling ... See more keywords
Development and validation of a leukocyte‐associated immunoglobulin‐like receptor‐1 prognostic signature for lower‐grade gliomas
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DOI: 10.1002/cam4.4945
Abstract: Leukocyte‐associated immunoglobulin‐like receptor‐1 (LAIR‐1), is an immunosuppressive receptor, widely expressed by immune cells, but the part of LAIR‐1 in glioma progression remains unclear. The purpose of this study was to explore the relationship between LAIR‐1… read more here.
Keywords: like receptor; associated immunoglobulin; leukocyte associated; receptor ... See more keywords
Conjugation of a Toll‐Like Receptor Agonist to Glycans of an HIV Native‐Like Envelope Trimer Preserves Neutralization Epitopes
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DOI: 10.1002/cbic.202200236
Abstract: Small molecule adjuvants are attractive for enhancing broad protection and durability of immune responses elicited by subunit vaccines. Covalent attachment of an adjuvant to an immunogen is particularly attractive because it simultaneously delivers both entities… read more here.
Keywords: envelope trimer; native like; toll like; like receptor ... See more keywords
Applying Modeling and Simulations for Rational Dose Selection of Novel Toll‐Like Receptor 7/8 Inhibitor Enpatoran for Indications of High Medical Need
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DOI: 10.1002/cpt.2606
Abstract: Dual toll‐like receptor (TLR) 7 and TLR8 inhibitor enpatoran is under investigation as a treatment for lupus and coronavirus disease 2019 (COVID‐19) pneumonia. Population pharmacokinetic/pharmacodynamic (PopPK/PD) model‐based simulations, using PK and PD (inhibition of ex… read more here.
Keywords: toll like; like receptor; dose selection; inhibitor enpatoran ... See more keywords
NOD‐like receptor protein 3 activation causes spontaneous inflammation and fibrosis that mimics human NASH
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DOI: 10.1002/hep.32320
Abstract: The NOD‐like receptor protein 3 (NLRP3) inflammasome is a central contributor to human acute and chronic liver disease, yet the molecular and cellular mechanisms by which its activation precipitates injury remain incompletely understood. Here, we… read more here.
Keywords: nod like; like receptor; inflammation fibrosis; receptor protein ... See more keywords
MiR‐150 alleviates neuropathic pain via inhibiting toll‐like receptor 5
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DOI: 10.1002/jcb.26269
Abstract: MicroRNAs (miRNAs) are reported as vital participators in the pathophysiological course of neuropathic pain. However, the underlying mechanisms of the functional roles of miRNAs in neuropathic pain are largely unknown. This study was designed to… read more here.
Keywords: toll like; like receptor; mir 150; neuropathic pain ... See more keywords
Toll like receptor signaling pathway as a potential therapeutic target in colorectal cancer
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DOI: 10.1002/jcp.26273
Abstract: Toll like receptor (TLR) signaling is involved in activating innate and adaptive immune responses and plays a critical role in inflammation‐induced diseases such as colorectal cancer (CRC). Dysregulation of this signaling pathway can result in… read more here.
Keywords: toll like; colorectal cancer; like receptor; signaling pathway ... See more keywords
Melatonin, a toll‐like receptor inhibitor: Current status and future perspectives
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DOI: 10.1002/jcp.27698
Abstract: Toll‐like receptors (TLRs) are crucial activators of inflammatory responses, they are considered immune receptors. TLRs are of fundamental importance in the pathophysiology of disorders related to inflammation including neurodegenerative diseases and cancer. Melatonin is a… read more here.
Keywords: melatonin toll; toll like; receptor inhibitor; like receptor ... See more keywords
Localization of vasoactive intestinal peptide and toll‐like receptor 2 immunoreactive cells in endostyle of urochordate Styela plicata (Lesueur, 1823)
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DOI: 10.1002/jemt.24119
Abstract: The endostyle is the first component of the ascidian digestive tract, it is shaped like a through and is located in the pharynx's ventral wall. This organ is divided longitudinally into nine zones that are… read more here.
Keywords: toll like; intestinal peptide; styela plicata; like receptor ... See more keywords