Nanomaterials‐Mediated Co‐Stimulation of Toll‐Like Receptors and CD40 for Antitumor Immunity
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DOI: 10.1002/adma.202207486
Abstract: Toll‐like receptors (TLRs) and CD40‐related signaling pathways represent critical bridges between innate and adaptive immune responses. Here, an immunotherapy regimen that enables co‐stimulation of TLR7/8‐ and CD40‐mediated pathways is developed. TLR7/8 agonist resiquimod (R848) derived… read more here.
Keywords: toll like; immunity; stimulation; nanomaterials mediated ... See more keywords
Isobavachalcone suppresses the TRIF‐dependent signaling pathway of Toll‐like receptors
Sign Up to like & getrecommendations! Published in 2021 at "Archiv der Pharmazie"
DOI: 10.1002/ardp.202100404
Abstract: Toll‐like receptors (TLRs) are integral membrane‐bound receptors that are central to innate and adaptive immune responses. They are known to activate a cascade of downstream signals to induce the secretion of inflammatory cytokines, chemokines, and… read more here.
Keywords: dependent signaling; trif dependent; signaling pathways; like receptors ... See more keywords
Satellite glial cells in human trigeminal ganglia have a broad expression of functional Toll‐like receptors
Sign Up to like & getrecommendations! Published in 2017 at "European Journal of Immunology"
DOI: 10.1002/eji.201746989
Abstract: Toll‐like receptors (TLRs) orchestrate immune responses to a wide variety of danger‐ and pathogen‐associated molecular patterns. Compared to the central nervous system (CNS), expression profile and function of TLRs in the human peripheral nervous system… read more here.
Keywords: toll like; satellite glial; glial cells; trigeminal ganglia ... See more keywords
Impact of curcumin on toll‐like receptors
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DOI: 10.1002/jcp.28103
Abstract: Toll‐like receptors (TLRs) have a pivotal role in the activation of innate immune response and inflammation. TLRs can be divided into two subgroups including extracellular TLRs that recognize microbial membrane components (TLR1, 2, 4, 5,… read more here.
Keywords: like receptors; toll like; impact curcumin; effect ... See more keywords
Toll‐like receptors in the functional orientation of cardiac progenitor cells
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DOI: 10.1002/jcp.28738
Abstract: Cardiac progenitor cells (CPCs) have the potential to differentiate into several cell lineages with the ability to restore in cardiac tissue. Multipotency and self‐renewal activity are the crucial characteristics of CPCs. Also, CPCs have promising… read more here.
Keywords: toll like; progenitor cells; receptors functional; cardiac progenitor ... See more keywords
Individual genetic variability mainly of Proinflammatory cytokines, cytokine receptors, and toll‐like receptors dictates pathophysiology of COVID‐19 disease
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Medical Virology"
DOI: 10.1002/jmv.27849
Abstract: Innate and acquired immunity responses are crucial for viral infection elimination. However, genetic variations in coding genes may exacerbate the inflammation or initiate devastating cytokine storms which poses severe respiratory conditions in coronavirus disease‐19 (COVID‐19).… read more here.
Keywords: toll like; cytokine receptors; cytokines cytokine; proinflammatory cytokines ... See more keywords
The function of NOD‐like receptors in central nervous system diseases
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DOI: 10.1002/jnr.24004
Abstract: NOD‐like receptors (NLRs) are critical cytoplasmic pattern‐recognition receptors (PRRs) that play an important role in the host innate immune response and immunity homeostasis. There is a growing body of evidence that NLRs are involved in… read more here.
Keywords: nervous system; central nervous; nod like; like receptors ... See more keywords
Possible Role for Toll-Like Receptors in Interaction of Fasciola hepatica Excretory-Secretory Products with Human Monocyte Cell Line.
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DOI: 10.1007/978-1-0716-0475-5_12
Abstract: This chapter presents a proteomic approach to purify and identify native excretory-secretory products (ESPs) in the range of >10-30 kDa proteins capable of interacting with toll-like receptors (TLRs). Here we present a protocol to fractionate the… read more here.
Keywords: toll like; excretory secretory; secretory products; fasciola hepatica ... See more keywords
Structural Biology of NOD-Like Receptors.
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DOI: 10.1007/978-981-13-9367-9_6
Abstract: The nucleotide-binding domain (NBD) and leucine-rich repeat (LRR) containing (NLR) proteins are a large family of intracellular immune receptors conserved in both animals and plants. Mammalian NLRs function as pattern recognition receptors (PRRs) to sense… read more here.
Keywords: structural biology; biology nod; nod like; biology ... See more keywords
The regulatory role of Toll-like receptors after ischemic stroke: neurosteroids as TLR modulators with the focus on TLR2/4
Sign Up to like & getrecommendations! Published in 2018 at "Cellular and Molecular Life Sciences"
DOI: 10.1007/s00018-018-2953-2
Abstract: Ischemic stroke is the most common cerebrovascular disease and considered as a worldwide leading cause of death. After cerebral ischemia, different pathophysiological processes including neuroinflammation, invasion and aggregation of inflammatory cells and up-regulation of cytokines… read more here.
Keywords: regulatory role; toll like; ischemic stroke; role ... See more keywords
NOD2 and reproduction-associated NOD-like receptors have been lost during the evolution of pangolins
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DOI: 10.1007/s00251-021-01230-9
Abstract: NOD-like receptors (NLRs) are sensors of pathogen-associated molecular patterns with critical roles in the control of immune responses and programmed cell death. Recent studies have revealed inter-species differences in mammalian innate immune genes and a… read more here.
Keywords: reproduction associated; nod2 reproduction; nod like; like receptors ... See more keywords