Carvacrol suppresses inflammatory responses in rheumatoid arthritis fibroblast‐like synoviocytes
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.28098
Abstract: Fibroblast‐like synoviocytes (FLSs) play an essential role in the chronic inflammatory process of rheumatoid arthritis (RA). Carvacrol is a natural monoterpenic phenol that retains significant anti‐inflammatory activity. However, the effect of carvacrol on inflammatory response… read more here.
Keywords: suppresses inflammatory; fibroblast like; like synoviocytes; carvacrol suppresses ... See more keywords
Forkhead box o3a suppresses lipopolysaccharide‐stimulated proliferation and inflammation in fibroblast‐like synoviocytes through regulating tripartite motif‐containing protein 3
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.28615
Abstract: Fibroblast‐like synoviocytes (FLS), synovial tissue‐specific cells, are key effector cells during the pathogenesis of rheumatoid arthritis (RA). Our previous study has shown that tripartite motif‐containing protein 3 (TRIM3) overexpression inhibits the proliferation and cytokine secretion… read more here.
Keywords: foxo3a trim3; fibroblast like; like synoviocytes; foxo3a ... See more keywords
Sam68 Promotes Invasion, Migration, and Proliferation of Fibroblast-like Synoviocytes by Enhancing the NF-κB/P65 Pathway in Rheumatoid Arthritis
Sign Up to like & getrecommendations! Published in 2018 at "Inflammation"
DOI: 10.1007/s10753-018-0809-4
Abstract: Src-associated substrate during mitosis of 68 KDa (Sam68), also known as KH domain containing, RNA binding, signal transduction associated 1 (KHDRBS1), is the prototypic member of the signal transduction activator of RNA (STAR) family of RNA-binding… read more here.
Keywords: fibroblast like; like synoviocytes; proliferation; migration ... See more keywords
miR-410-3p Suppresses Cytokine Release from Fibroblast-Like Synoviocytes by Regulating NF-κB Signaling in Rheumatoid Arthritis
Sign Up to like & getrecommendations! Published in 2018 at "Inflammation"
DOI: 10.1007/s10753-018-0896-2
Abstract: AbstractmiR-410-3p acts as an oncogene or a tumor suppressor in some malignancies. However, its role in rheumatoid arthritis (RA) is unknown. The study was conducted to investigate the effect of miR-410-3p on the pathogenesis of… read more here.
Keywords: 410 suppresses; fibroblast like; regulating signaling; like synoviocytes ... See more keywords
A20 inhibits the release of inflammatory cytokines by suppressing the activation of the nuclear factor-kappa B pathway in osteoarthritic fibroblast-like synoviocytes.
Sign Up to like & getrecommendations! Published in 2019 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2018.12.030
Abstract: A growing number of studies suggest that synovitis plays an important role in the pathogenesis and progression of osteoarthritis (OA). As a negative mediator of the nuclear factor-kappa B (NF-κB) signaling pathway, the zinc finger… read more here.
Keywords: fibroblast like; like synoviocytes; inflammatory cytokines; factor kappa ... See more keywords
Antifibrotic effect of brown algae-derived fucoidans on osteoarthritic fibroblast-like synoviocytes.
Sign Up to like & getrecommendations! Published in 2022 at "Carbohydrate polymers"
DOI: 10.1016/j.carbpol.2022.119134
Abstract: Synovial fibrosis is a pathological process which contributes to joint pain and stiffness in several musculoskeletal disorders. Fucoidans, sulfated polysaccharides found in brown algae, have recently emerged as promising therapeutic agents. Despite the increasing amount… read more here.
Keywords: fibroblast like; like synoviocytes; effect; sulfated polysaccharides ... See more keywords
Imperatorin Inhibits Proliferation, Migration, and Inflammation via Blocking the NF-κB and MAPK Pathways in Rheumatoid Fibroblast-like Synoviocytes
Sign Up to like & getrecommendations! Published in 2022 at "ACS Omega"
DOI: 10.1021/acsomega.2c02766
Abstract: Rheumatoid arthritis (RA) is a chronic joint inflammatory disease associated with the aberrant activation of fibroblast-like synoviocytes (FLSs). Searching for natural compounds that may suppress the activation of FLSs has become a complementary approach for… read more here.
Keywords: proliferation migration; fibroblast like; flss; like synoviocytes ... See more keywords
Growth factors regulate phospholipid biosynthesis in human fibroblast-like synoviocytes obtained from osteoarthritic knees
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-14004-9
Abstract: Elevated levels of growth factors and phospholipids (PLs) have been found in osteoarthritic synovial fluid (SF), although the metabolic regulation of PLs is currently unknown. This study aimed to determine the effects of growth factors… read more here.
Keywords: biosynthesis; fibroblast like; like synoviocytes; growth factors ... See more keywords
(5R)-5-Hydroxytriptolide (LLDT-8) induces substantial epigenetic mediated immune response network changes in fibroblast-like synoviocytes from rheumatoid arthritis patients
Sign Up to like & getrecommendations! Published in 2019 at "Scientific Reports"
DOI: 10.1038/s41598-019-47411-1
Abstract: Tripterygium is a traditional Chinese medicine that has widely been used in the treatment of rheumatic disease. (5R)-5-hydroxytriptolide (LLDT-8) is an extracted compound from Tripterygium, which has been shown to have lower cytotoxicity and relatively… read more here.
Keywords: fibroblast like; network; lldt; like synoviocytes ... See more keywords
TNF induces glycolytic shift in fibroblast like synoviocytes via GLUT1 and HIF1A
Sign Up to like & getrecommendations! Published in 2021 at "Scientific Reports"
DOI: 10.1038/s41598-021-98651-z
Abstract: TNF is a central cytokine in the pathogenesis of rheumatoid arthritis (RA). Elevated level of TNF causes local inflammation that affects immune cells and fibroblast-like synoviocytes (FLS). Nowadays, only 20–30% of patients experience remission after… read more here.
Keywords: fibroblast like; tnf; like synoviocytes; fls ... See more keywords
sFRP3 and DKK1 Regulate Fibroblast-Like Synoviocytes Markers and Wnt Elements Expression Depending on Cellular Context
Sign Up to like & getrecommendations! Published in 2017 at "Immunological Investigations"
DOI: 10.1080/08820139.2016.1267204
Abstract: ABSTRACT Context: Fibroblast-like synoviocytes (FLS) from rheumatoid arthritis (RA) display pathogenic behavior. Various members of the Wnt pathway, especially the canonical Wnt/β-catenin cascade, may contribute to autonomous RA FLS activation. It has been shown that… read more here.
Keywords: fibroblast like; like synoviocytes; fls; expression ... See more keywords