YAP/STAT3 promotes the immune escape of larynx carcinoma by activating VEGFR1-TGFβ signaling to facilitate PD-L1 expression in M2-like TAMs.
Sign Up to like & getrecommendations! Published in 2021 at "Experimental cell research"
DOI: 10.1016/j.yexcr.2021.112655
Abstract: Larynx carcinoma (LC) is the most prevalent head and neck cancer among adults. LC xenograft mouse model was generated to verify the effect of VEGF on macrophage polarization and tumor growth in vivo. EdU assay… read more here.
Keywords: larynx carcinoma; like tams; activating vegfr1; expression ... See more keywords
Depletion of tumor‐associated macrophages inhibits lung cancer growth and enhances the antitumor effect of cisplatin
Sign Up to like & getrecommendations! Published in 2022 at "Cancer Science"
DOI: 10.1111/cas.15671
Abstract: In lung cancer, tumor‐associated macrophages (TAMs), especially M2‐like TAMs, represent the main tumor progression components in the tumor microenvironment (TME). Therefore, M2‐like TAMs may serve as a therapeutic target. The purpose of this study was… read more here.
Keywords: lung cancer; mcp; like tams; tumor ... See more keywords
Tumor Microenvironment Remodeling via Targeted Depletion of M2-like Tumor-Associated Macrophages for Cancer Immunotherapy.
Sign Up to like & getrecommendations! Published in 2023 at "Acta biomaterialia"
DOI: 10.2139/ssrn.4185626
Abstract: M2-like tumor-associated macrophages (TAMs) typically exhibit numerous tumor-promoting properties. Reducing the abundance of M2-like TAMs would shed light on the relief of immunosuppressive tumor microenvironment (TME), activation of the host immune system, infiltration of CD8+… read more here.
Keywords: immunotherapy; depletion like; like tams; tumor ... See more keywords
M2-like tumour-associated macrophage-secreted IGF promotes thyroid cancer stemness and metastasis by activating the PI3K/AKT/mTOR pathway
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DOI: 10.3892/mmr.2021.12249
Abstract: M2-like tumour-associated macrophages (TAMs) have been demonstrated to promote the growth of anaplastic thyroid carcinoma (ATC). However, the underlying mechanism of M2-like TAMs in ATC remains unclear. Thus, in the present study, the role and… read more here.
Keywords: stemness; like tams; pi3k akt; igf ... See more keywords