Immunoglobulinâlike transcript 2 blockade restores antitumor immune responses in glioblastoma
Sign Up to like & getrecommendations! Published in 2022 at "Cancer Science"
DOI: 10.1111/cas.15575
Abstract: Glioblastoma stands as the most frequent primary brain tumor. Despite the multimodal therapy for glioblastoma patients, the survival rate is very low, highlighting the need for novel therapies that improve patient outcomes. Immune checkpoint blockade… read more here.
Keywords: responses glioblastoma; transcript blockade; blockade; like transcript ... See more keywords
TREM-like transcript 1: a more sensitive marker of platelet activation than P-selectin in humans and mice.
Sign Up to like & getrecommendations! Published in 2018 at "Blood advances"
DOI: 10.1182/bloodadvances.2018017756
Abstract: Key Points Platelet activation in vitro results in a more rapid and greater upregulation of TLT-1 surface expression compared with P-selectin. TLT-1 is more rapidly translocated to the surface of activated platelets than P-selectin during… read more here.
Keywords: sensitive marker; trem like; platelet activation; activation ... See more keywords
Interleukin-6 is a key factor for immunoglobulin-like transcript-4-mediated immune injury in sepsis
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Intensive Care"
DOI: 10.1186/s40560-018-0294-8
Abstract: BackgroundILT4+ monocytes seem to be associated with poor prognosis of sepsis in humans, but the exact mechanisms are unknown. This study aimed to examine the biological behaviors and effects of immunoglobulin-like transcript-4 (ILT4) levels on… read more here.
Keywords: clp; sepsis; peripheral blood; like transcript ... See more keywords
Soluble TREM-like Transcript-1 Acts as a Damage-Associated Molecular Pattern through the TLR4/MD2 Pathway Contributing to Immune Dysregulation during Sepsis.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of immunology"
DOI: 10.4049/jimmunol.2200222
Abstract: Studies have shown that elevated plasma levels of platelet-derived soluble TREM-like transcript-1 (sTLT-1) are associated with an unfavorable outcome in patients with septic shock. However, the underlying molecular mechanisms are not well defined. This research… read more here.
Keywords: sepsis; tlr4 md2; trem like; soluble trem ... See more keywords