Myeloid immune checkpoint ILT3/LILRB4/gp49B can co-tether fibronectin with integrin on macrophages.
Sign Up to like & getrecommendations! Published in 2022 at "International immunology"
DOI: 10.1093/intimm/dxac023
Abstract: LILRB4 (B4, also known as ILT3/CD85k) is an immune checkpoint of myeloid-lineage cells, albeit its mode of function remains obscure. Our recent identification of a common ligand for both human B4 and its murine ortholog… read more here.
Keywords: immune checkpoint; lilrb4; integrin; tether fibronectin ... See more keywords
Upregulation of leukocyte immunoglobulin-like receptor B4 on interstitial macrophages in COPD; their possible protective role against emphysema formation
Sign Up to like & getrecommendations! Published in 2021 at "Respiratory Research"
DOI: 10.1186/s12931-021-01828-3
Abstract: Background Leukocyte immunoglobulin-like receptor B4 (LILRB4) is one of the inhibitory receptors in various types of immune cells including macrophages. Previous reports suggested that LILRB4 could be involved in a negative feedback system to prevent… read more here.
Keywords: interstitial macrophages; lilrb4; emphysema; copd ... See more keywords
Characterization and functional analyses of novel chicken leukocyte immunoglobulin-like receptor subfamily B members 4 and 5.
Sign Up to like & getrecommendations! Published in 2019 at "Poultry science"
DOI: 10.3382/ps/pez442
Abstract: The inhibitory leukocyte immuno-globulin-like receptors (LILRBs) play an important role in innate immunity. Currently, no data exist regarding the role of LILRB4 and LILRB5 in the activation of immune signaling pathways in mammalian and avian… read more here.
Keywords: characterization functional; functional analyses; lilrb4; expression ... See more keywords
LILRB4 Decrease on uDCs Exacerbate Abnormal Pregnancy Outcomes Following Toxoplasma gondii Infection
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DOI: 10.3389/fmicb.2018.00588
Abstract: Toxoplasma gondii (T. gondii) infection in early pregnancy can result in miscarriage, dead fetus, and other abnormalities. The LILRB4 is a central inhibitory receptor in uterine dendritic cells (uDCs) that plays essential immune-regulatory roles at… read more here.
Keywords: gondii infection; lilrb4; infection; abnormal pregnancy ... See more keywords
Molecular regulatory mechanism of LILRB4 in the immune response
Sign Up to like & getrecommendations! Published in 2023 at "Central-European Journal of Immunology"
DOI: 10.5114/ceji.2023.125238
Abstract: Immune diseases are caused by the imbalance of immune regulation. This imbalance is regulated by many factors, both negative and positive. Leukocyte immunoglobulin-like receptor B4 (LILRB4) is a member of leukocyte immunoglobulin-like receptors (LILRs). LILRs… read more here.
Keywords: lilrb4 immune; lilrb4; molecular regulatory; immune response ... See more keywords