Human ERG oncoprotein represses a Drosophila LIM domain binding protein-coding gene Chip.
Sign Up to like & getrecommendations! Published in 2023 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2211189119
Abstract: Human ETS Related Gene, ERG, a master transcription factor, turns oncogenic upon its out-of-context activation in diverse developmental lineages. However, the mechanism underlying its lineage-specific activation of Notch (N), Wnt, or EZH2-three well-characterized oncogenic targets… read more here.
Keywords: represses drosophila; lim domain; erg; domain binding ... See more keywords
Direct Knockdown of PDZ and LIM Domain 1 Using an Adenoviral Delivery System Accelerates Osteogenesis and Fracture Healing in Mice.
Sign Up to like & getrecommendations! Published in 2023 at "Human gene therapy"
DOI: 10.1089/hum.2023.009
Abstract: Substantial advances have been made in understanding the role of partial PDZ and LIM domain (PDLIM) family's proteins in skeletal-related diseases. Yet, little is known about the effect of Pdlim1 on osteogenesis and fracture repair.… read more here.
Keywords: pdlim1; fracture; pdz lim; osteogenesis fracture ... See more keywords
Discovery of Novel Small-Molecule Inhibitors of LIM Domain Kinase for Inhibiting HIV-1
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Virology"
DOI: 10.1128/jvi.02418-16
Abstract: ABSTRACT A dynamic actin cytoskeleton is necessary for viral entry, intracellular migration, and virion release. For HIV-1 infection, during entry, the virus triggers early actin activity by hijacking chemokine coreceptor signaling, which activates a host… read more here.
Keywords: domain kinase; kinase; small molecule; discovery ... See more keywords
LIM-Domain-Binding Protein 1 Mediates Cell Proliferation and Drug Resistance in Colorectal Cancer
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Surgery"
DOI: 10.3389/fsurg.2021.790380
Abstract: Objective: It has been shown that LIM-domain-binding protein 1 (LDB1) is involved in the tumorigenesis of several cancers, but its function in colorectal cancer (CRC) has not been fully explained. This study is aimed to… read more here.
Keywords: drug; ldb1; lim domain; cell ... See more keywords