Mechanosensing through Direct Binding of Tensed F-Actin by LIM Domains.
Sign Up to like & getrecommendations! Published in 2020 at "Developmental cell"
DOI: 10.1016/j.devcel.2020.09.022
Abstract: Mechanical signals transmitted through the cytoplasmic actin cytoskeleton must be relayed to the nucleus to control gene expression. LIM domains are protein-protein interaction modules found in cytoskeletal proteins and transcriptional regulators. Here, we identify three… read more here.
Keywords: lim domains; binding tensed; mechanosensing direct; tensed actin ... See more keywords
Computational analysis of the flexibility in the disordered linker region connecting LIM domains in cysteine–glycine-rich protein
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Genetics"
DOI: 10.3389/fgene.2023.1134509
Abstract: One of the key proteins that are present in the Z-disc of cardiac tissues, CSRP3, has been implicated in dilated and hypertrophic cardiomyopathy leading to heart failure. Although multiple cardiomyopathy-related mutations have been reported to… read more here.
Keywords: disordered linker; linker region; flexibility disordered; lim domains ... See more keywords