Pharmacological inhibition of LIM kinase pathway impairs platelets functionality and facilitates thrombolysis.
Sign Up to like & getrecommendations! Published in 2019 at "Experimental cell research"
DOI: 10.1016/j.yexcr.2019.06.003
Abstract: Actin is highly abundant in platelets, and its function is dependent on its structure. Actin filaments (F-actin) are dynamic structures involved in many cellular processes including platelet shape changes and adhesion. The actin cytoskeleton is… read more here.
Keywords: actin; inhibition; pharmacological inhibition; inhibition lim ... See more keywords
A Par3/LIM Kinase/Cofilin Pathway Mediates Human Airway Smooth Muscle Relaxation by TAS2R14.
Sign Up to like & getrecommendations! Published in 2023 at "American journal of respiratory cell and molecular biology"
DOI: 10.1165/rcmb.2022-0303oc
Abstract: Bitter taste receptors (TAS2Rs) are G protein-coupled receptors expressed on human airway smooth muscle (HASM) cells; when activated by receptor agonists they evoke marked airway relaxation. In both taste and HASM cells, TAS2Rs activate a… read more here.
Keywords: lim kinase; tas2r14; relaxation; human airway ... See more keywords