New insight into functional limb regeneration: A to Z approaches
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Tissue Engineering and Regenerative Medicine"
DOI: 10.1002/term.2727
Abstract: Limb/digit amputation is a common event in humans caused by trauma, medical illness, or surgery. Although the loss of a digit is not lethal, it affects quality of life and imposes high costs on amputees.… read more here.
Keywords: tissue engineering; functional limb; limb regeneration; regeneration ... See more keywords
Evolution and Regulation of Limb Regeneration in Arthropods.
Sign Up to like & getrecommendations! Published in 2019 at "Results and problems in cell differentiation"
DOI: 10.1007/978-3-030-23459-1_17
Abstract: Regeneration has fascinated both scientists and non-scientists for centuries. Many organisms can regenerate, and arthropod limbs are no exception although their ability to regenerate is a product shaped by natural and sexual selection. Recent studies… read more here.
Keywords: regeneration arthropods; regeneration; regulation limb; evolution regulation ... See more keywords
Expression and function of WNT4 involved in larvae development and limb regeneration in Portunus trituberculatus
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Oceanology and Limnology"
DOI: 10.1007/s00343-020-9291-6
Abstract: The wingless-related integration site (WNT) proteins are a family of secreted glycoproteins that are evolutionarily conserved and are believed to be involved in evolution in vertebrates and invertebrates. WNT signaling pathways may be associated with… read more here.
Keywords: trituberculatus; wnt4; expression; limb regeneration ... See more keywords
A Tissue-Mapped Axolotl De Novo Transcriptome Enables Identification of Limb Regeneration Factors.
Sign Up to like & getrecommendations! Published in 2017 at "Cell reports"
DOI: 10.1016/j.celrep.2016.12.063
Abstract: Mammals have extremely limited regenerative capabilities; however, axolotls are profoundly regenerative and can replace entire limbs. The mechanisms underlying limb regeneration remain poorly understood, partly because the enormous and incompletely sequenced genomes of axolotls have… read more here.
Keywords: novo transcriptome; regeneration; tissue mapped; mapped axolotl ... See more keywords
Transcriptomic landscape of the blastema niche in regenerating adult axolotl limbs at single-cell resolution
Sign Up to like & getrecommendations! Published in 2018 at "Nature Communications"
DOI: 10.1038/s41467-018-07604-0
Abstract: Regeneration of complex multi-tissue structures, such as limbs, requires the coordinated effort of multiple cell types. In axolotl limb regeneration, the wound epidermis and blastema have been extensively studied via histology, grafting, and bulk-tissue RNA-sequencing.… read more here.
Keywords: single cell; blastema; regeneration; adult axolotl ... See more keywords
Osteoclast-mediated resorption primes the skeleton for successful integration during axolotl limb regeneration
Sign Up to like & getrecommendations! Published in 2022 at "eLife"
DOI: 10.1101/2022.04.27.489662
Abstract: Early events during axolotl limb regeneration include an immune response and the formation of a wound epithelium. These events are linked to a clearance of damaged tissue prior to blastema formation and regeneration of the… read more here.
Keywords: resorption; regeneration; successful integration; limb regeneration ... See more keywords
Using transcriptomics to enable a plethodontid salamander (Bolitoglossa ramosi) for limb regeneration research
Sign Up to like & getrecommendations! Published in 2018 at "BMC Genomics"
DOI: 10.1186/s12864-018-5076-0
Abstract: BackgroundTissue regeneration is widely distributed across the tree of life. Among vertebrates, salamanders possess an exceptional ability to regenerate amputated limbs and other complex structures. Thus far, molecular insights about limb regeneration have come from… read more here.
Keywords: plethodontid salamander; regeneration; salamander bolitoglossa; limb regeneration ... See more keywords
Identification of axolotl BH3-only proteins and expression in axolotl organs and apoptotic limb regeneration tissue
Sign Up to like & getrecommendations! Published in 2018 at "Biology Open"
DOI: 10.1242/bio.036293
Abstract: ABSTRACT Like other urodela amphibians, axolotls are able to regenerate lost appendages, even as adults, rendering them unique among higher vertebrates. In reaction to the severe trauma of a lost limb, apoptosis seems to be… read more here.
Keywords: limb regeneration; bcl family; axolotl; tissue ... See more keywords