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   Articles with "limbal stem" as a keyword



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Outcomes of Limbal Stem Cell Transplant: A Meta-analysis.

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recommendations! Published in 2020 at "JAMA ophthalmology"

DOI: 10.1001/jamaophthalmol.2020.1120

Abstract: Importance Limbal stem cell transplant (LSCT) can be categorized as direct autologous limbal transplant (AULT), direct allogenic limbal transplant (ALLT), cultivated autologous limbal stem cells transplant (cAULT), and cultivated allogenic limbal stem cells transplant (cALLT).… read more here.

Keywords: limbal stem; stem cell; stem; cell transplant ... See more keywords

Comparison of the efficacy of different cell sources for transplantation in total limbal stem cell deficiency

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recommendations! Published in 2019 at "Graefe's Archive for Clinical and Experimental Ophthalmology"

DOI: 10.1007/s00417-019-04316-z

Abstract: PurposeThe purpose of this study was to compare the efficacy of allogeneic cultured limbal epithelial transplantation (ACLET) and cultivated oral mucosal epithelial transplantation (COMET) in treating total limbal stem cell deficiency (LSCD).MethodsIn this retrospective cohort… read more here.

Keywords: aclet; limbal stem; stem cell; transplantation ... See more keywords

Autologous transplantation of conjunctiva by modifying simple limbal epithelial transplantation for limbal stem cell deficiency

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recommendations! Published in 2019 at "Japanese Journal of Ophthalmology"

DOI: 10.1007/s10384-019-00701-7

Abstract: Purpose As a treatment to replace regenerative medicine to treat limbal stem cell deficiency (LSCD), we performed 4 consecutive cases of autologous transplantation of conjunctival explants by modifying simple limbal epithelial transplantation (SLET). Study design… read more here.

Keywords: limbal stem; stem cell; transplantation; autologous transplantation ... See more keywords
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Influence of graft vascularization on graft survival following homologous limbo-keratoplasty

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recommendations! Published in 2022 at "International Ophthalmology"

DOI: 10.1007/s10792-022-02291-9

Abstract: Limbo-keratoplasty enables visual improvement and limbal stem cell transplantation at the same. During follow-up, most grafts show vascularization of the limbus. However, it is unclear whether vascularization is harmful due to immunologic effects or helpful… read more here.

Keywords: graft survival; vascularization; limbal stem; cell ... See more keywords
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Limbal Stem Cell Deficiency-Demography and Underlying Causes.

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recommendations! Published in 2018 at "American journal of ophthalmology"

DOI: 10.1016/j.ajo.2018.01.020

Abstract: PURPOSE To determine the demographic features of patients affected by limbal stem cell deficiency (LSCD), and to identify the underlying causes of LSCD. DESIGN Retrospective, multicenter case series. SETTING Two large tertiary care ophthalmology hospitals.… read more here.

Keywords: cause; ophthalmology; limbal stem; stem cell ... See more keywords
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Spectral-domain Optical Coherence Tomography in Limbal Stem Cell Deficiency. A Case-Control Study.

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recommendations! Published in 2018 at "American journal of ophthalmology"

DOI: 10.1016/j.ajo.2018.03.034

Abstract: PURPOSE To evaluate the efficacy of optical coherence tomography (OCT) as a noncontact method for imaging the ocular surface in limbal stem cell deficiency (LSCD) and normal eyes. DESIGN Retrospective case-control study. METHODS Setting: Institutional.… read more here.

Keywords: optical coherence; control; group; study ... See more keywords

A Small-Molecule Wnt Mimic Improves Human Limbal Stem Cell Ex Vivo Expansion

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recommendations! Published in 2020 at "iScience"

DOI: 10.1016/j.isci.2020.101075

Abstract: Summary Ex vivo cultured limbal stem/progenitor cells is an effective alternative to other surgical treatments for limbal stem cell deficiency, but a standard xenobiotic-free method for culturing the LSCs in vitro needs to be optimized.… read more here.

Keywords: expansion; wnt mimic; limbal stem; stem cell ... See more keywords
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Timolol induces necroptosis, apoptosis and senescence concentration-dependently in rabbit Limbal stem cells in vitro.

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recommendations! Published in 2021 at "Life sciences"

DOI: 10.1016/j.lfs.2021.119453

Abstract: Limbal stem cells (LSCs) are crucial for corneal transparency and vision. Any damages to LSCs might lead to limbal stem cell deficiency resulting in corneal opacification and even blindness. Here, we investigated the cytotoxicity of… read more here.

Keywords: caspase; apoptosis; senescence; limbal stem ... See more keywords
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Engraftment and Proliferation of Thermoreversible-Gelation-Polymer-Encapsulated Human Corneal Limbal-Stem-Cells on Ocular Surface of a Cadaver Cornea

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recommendations! Published in 2022 at "Current Eye Research"

DOI: 10.1080/02713683.2023.2180039

Abstract: Abstract Purpose Corneal limbal stem cell (LSC) transplantation has been reported as a potential approach to treat the damaged corneal epithelium. Scaffolds such as human amniotic membrane (hAM) are commonly employed for the in vitro… read more here.

Keywords: corneal limbal; limbal stem; gelation polymer; cornea ... See more keywords
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Limbal Stem Cell Transplantation and Complications

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recommendations! Published in 2018 at "Seminars in Ophthalmology"

DOI: 10.1080/08820538.2017.1353834

Abstract: ABSTRACT Corneal epithelial stem cells are adult somatic stem cells located at the limbus and represent the ultimate source of transparent corneal epithelium. When these limbal stem cells become dysfunctional or deficient, limbal stem cell… read more here.

Keywords: stem; limbal stem; cell transplantation; stem cell ... See more keywords
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Long-Term Comprehensive Management of Bilateral Limbal Stem Cell Deficiency Secondary to Severe Chemical Burn: 10 Years of Follow-Up.

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recommendations! Published in 2022 at "Ocular immunology and inflammation"

DOI: 10.1080/09273948.2022.2090965

Abstract: PURPOSE To describe the long-term management of bilateral limbal stem cell deficiency secondary to a severe chemical burn. METHODS Descriptive case report. IMPORTANCE This case highlights the importance of early intervention in ocular chemical burns… read more here.

Keywords: long term; limbal stem; stem cell; management bilateral ... See more keywords