Mechanisms of decreased cholinergic arousal in focal seizures: In vivo whole-cell recordings from the pedunculopontine tegmental nucleus
Sign Up to like & getrecommendations! Published in 2019 at "Experimental Neurology"
DOI: 10.1016/j.expneurol.2018.11.008
Abstract: &NA; Focal limbic seizures often impair consciousness/awareness with major negative impact on quality of life. Recent work has shown that limbic seizures depress brainstem arousal systems, including reduced action potential firing in a key node:… read more here.
Keywords: whole cell; cholinergic neurons; pedunculopontine tegmental; limbic seizures ... See more keywords
Unraveling the Effects of GSK-3β Isoform Modulation against Limbic Seizures and in the 6 Hz Electrical Kindling Model for Epileptogenesis.
Sign Up to like & getrecommendations! Published in 2022 at "ACS chemical neuroscience"
DOI: 10.1021/acschemneuro.1c00782
Abstract: Two closely related glycogen synthase kinase-3 (GSK-3) isoforms have been identified in mammals: GSK-3α and GSK-3β. GSK-3β is the most prominent in the central nervous system and was previously shown to control neuronal excitability. We… read more here.
Keywords: gsk gsk; kindling model; model; mice ... See more keywords
Up and Down States of Cortical Neurons in Focal Limbic Seizures.
Sign Up to like & getrecommendations! Published in 2019 at "Cerebral cortex"
DOI: 10.1093/cercor/bhz295
Abstract: Recent work suggests an important role for cortical-subcortical networks in seizure-related loss of consciousness. Temporal lobe seizures disrupt subcortical arousal systems, which may lead to depressed cortical function and loss of consciousness. Extracellular recordings show… read more here.
Keywords: focal limbic; states cortical; limbic seizures; loss consciousness ... See more keywords
Cortical low‐frequency power correlates with behavioral impairment in animal model of focal limbic seizures
Sign Up to like & getrecommendations! Published in 2021 at "Epilepsia"
DOI: 10.1111/epi.16964
Abstract: Impairment in consciousness is a debilitating symptom during and after seizures; however, its mechanism remains unclear. Limbic seizures have been shown to spread to arousal circuitry to result in a "network inhibition" phenomenon. However, prior… read more here.
Keywords: cortical low; frequency power; animal model; limbic seizures ... See more keywords
Noradrenaline and seizures: a perspective on the role of adrenergic receptors in limbic seizures.
Sign Up to like & getrecommendations! Published in 2022 at "Current neuropharmacology"
DOI: 10.2174/1570159x20666220327213615
Abstract: BACKGROUND Noradrenergic fibers originating from the locus coeruleus densely innervate limbic structures including the piriform cortex, which is the limbic structure with the lowest seizure threshold. Noradrenaline (NA) modulates limbic seizures, while stimulating autophagy through… read more here.
Keywords: seizure; piriform cortex; role; limbic seizures ... See more keywords