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   Articles with "limited sampling" as a keyword



Limited sampling strategy for predicting busulfan exposure in hematopoietic stem cell transplantation recipients

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recommendations! Published in 2017 at "International Journal of Clinical Pharmacy"

DOI: 10.1007/s11096-017-0481-z

Abstract: Background Optimization of the area under the concentration–time curve (AUC) of busulfan, an essential component of conditioning regimens, improves the outcomes in patients undergoing hematopoietic stem cell transplantation (HSCT). Traditional sampling methods for calculating AUC… read more here.

Keywords: busulfan; cell transplantation; limited sampling; stem cell ... See more keywords

A Limited Sampling Strategy to Estimate Exposure of Everolimus in Whole Blood and Peripheral Blood Mononuclear Cells in Renal Transplant Recipients Using Population Pharmacokinetic Modeling and Bayesian Estimators

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recommendations! Published in 2018 at "Clinical Pharmacokinetics"

DOI: 10.1007/s40262-018-0646-5

Abstract: Background and ObjectiveIntracellular exposure of everolimus may be a better marker of therapeutic effect than trough whole blood concentrations. We aimed to develop pharmacokinetic population models and Bayesian estimators based on a limited sampling strategy… read more here.

Keywords: exposure; limited sampling; renal transplant; blood ... See more keywords

Development of a Limited Sampling Strategy for the Estimation of Exposure to High-Dose Etoposide After Intravenous Infusion in Pediatric Patients

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recommendations! Published in 2017 at "Therapeutic Drug Monitoring"

DOI: 10.1097/ftd.0000000000000368

Abstract: Background: Etoposide (VP-16), a podophyllotoxin derivative, is used in conditioning regimens before allogeneic hematopoietic stem cell transplantation in children with acute lymphoblastic leukemia. The aim of this study was to develop a limited sampling strategy… read more here.

Keywords: estimation; infusion; limited sampling; strategy ... See more keywords
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Evaluation of Omeprazole Limited Sampling Strategies to Estimate Constitutive Cytochrome P450 2C19 Activity in Healthy Adults

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recommendations! Published in 2018 at "Therapeutic Drug Monitoring"

DOI: 10.1097/ftd.0000000000000554

Abstract: Background: Limited sampling strategy (LSS) is a validated method to estimate pharmacokinetic (PK) parameters from a reduced number of samples. Omeprazole is used to phenotype in vivo cytochrome P450 (CYP) 2C19 activity. This study examined… read more here.

Keywords: 2c19 activity; limited sampling; cytochrome p450; activity ... See more keywords

Limited Sampling Strategies Supporting Individualized Dose Adjustment of Intravenous Busulfan in Children and Young Adults.

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recommendations! Published in 2019 at "Therapeutic Drug Monitoring"

DOI: 10.1097/ftd.0000000000000700

Abstract: BACKGROUND AND AIMS Therapeutic drug monitoring (TDM) for busulfan supports dose adjustment during conditioning for stem cell transplantation. The authors aimed to develop and validate limited sampling strategies (LSS) of 4 to 5 samples for… read more here.

Keywords: sampling strategies; limited sampling; dose adjustment; busulfan ... See more keywords

Fexofenadine Plasma Concentrations to Estimate Systemic Exposure in Healthy Adults Using a Limited Sampling Strategy with a Population Pharmacokinetic Approach.

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recommendations! Published in 2023 at "Therapeutic drug monitoring"

DOI: 10.1097/ftd.0000000000001052

Abstract: BACKGROUND Fexofenadine is a recommended in vivo probe drug for phenotyping P-glycoprotein (P-gp) and organic anion transporting polypeptide (OATP) 1B1/3 transporter activities. This study evaluated a limited sampling strategy using a population pharmacokinetic approach to… read more here.

Keywords: percent; limited sampling; error; population pharmacokinetic ... See more keywords

Simulation-Based Optimization of Sampling Schedules for Model-Informed Precision Dosing of Once-Daily and 4-Times-Daily Busulfan in Pediatric Patients

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recommendations! Published in 2024 at "Therapeutic Drug Monitoring"

DOI: 10.1097/ftd.0000000000001217

Abstract: Supplemental Digital Content is Available in the Text. Background: Therapeutic drug monitoring (TDM) is crucial in optimizing the outcomes of hematopoietic stem cell transplantation by guiding busulfan (Bu) dosing. Limited sampling strategies show promise for… read more here.

Keywords: precision; pediatric patients; sampling schedules; model ... See more keywords

Limited sampling strategies for estimation of tacrolimus exposure in kidney transplant recipients receiving extended-release tacrolimus preparation.

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recommendations! Published in 2021 at "Clinical and translational science"

DOI: 10.1111/cts.12990

Abstract: Tacrolimus is the key component of most contemporary immunosuppressive drug regimens for the prevention of transplant rejection. Area under the concentration time curve over 24 h (AUC0-24 ) predicts efficacy, but predose (trough) tacrolimus blood… read more here.

Keywords: extended release; sampling strategies; kidney transplant; limited sampling ... See more keywords

RELATE: Relationship of limited sampling strategy and adverse effects of mycophenolate mofetil in pediatric renal transplant patients

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recommendations! Published in 2019 at "Pediatric Transplantation"

DOI: 10.1111/petr.13355

Abstract: MMF, a prodrug converted to the active form MPA, is an immunosuppressant used to prevent rejection in solid organ transplant recipients. MPA exposure, defined by AUC, can be estimated using limited sampling strategies (LSS). The… read more here.

Keywords: rejection; limited sampling; mpa auc; adverse effects ... See more keywords

Population Pharmacokinetic Modelling and Limited Sampling Strategies for Therapeutic Drug Monitoring of Pyrazinamide in Patients with Tuberculosis

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recommendations! Published in 2022 at "Antimicrobial Agents and Chemotherapy"

DOI: 10.1128/aac.00003-22

Abstract: Pyrazinamide is one of the first-line antituberculosis drugs. The efficacy of pyrazinamide is associated with the ratio of 24-h area under the concentration–time curve (AUC24) to MIC. ABSTRACT Pyrazinamide is one of the first-line antituberculosis… read more here.

Keywords: poppk model; therapeutic drug; limited sampling; population pharmacokinetic ... See more keywords

Photoacoustic imaging with limited sampling: a review of machine learning approaches.

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recommendations! Published in 2023 at "Biomedical optics express"

DOI: 10.1364/boe.483081

Abstract: Photoacoustic imaging combines high optical absorption contrast and deep acoustic penetration, and can reveal structural, molecular, and functional information about biological tissue non-invasively. Due to practical restrictions, photoacoustic imaging systems often face various challenges, such… read more here.

Keywords: learning approaches; limited sampling; photoacoustic imaging; machine learning ... See more keywords