Limiting RyR2 open time prevents Alzheimer's disease-related deficits in the 3xTG-AD mouse model.
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DOI: 10.1002/jnr.24936
Abstract: Increasing evidence suggests that Alzheimer's disease (AD) progression is driven by a vicious cycle of soluble β-amyloid (Aβ)-induced neuronal hyperactivity. Thus, breaking this vicious cycle by suppressing neuronal hyperactivity may represent a logical approach to… read more here.
Keywords: open time; limiting ryr2; mouse model; ryr2 open ... See more keywords