Circ‐Zfp644 acts as a pro‐hypertrophic mediator in an Ang‐II induced in vitro myocardial hypertrophy model
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DOI: 10.1002/cbin.11569
Abstract: Cardiac hypertrophy (CH) is a common risk factor for heart failure and even sudden cardiac death. Molecules have emerged as vital regulators in cardiac disorders. LIM domain kinase 1 (Limk1) is reported as a pro‐fibrotic… read more here.
Keywords: zfp644; mir; model; circ zfp644 ... See more keywords
LIMK1 nuclear translocation promotes hepatocellular carcinoma progression by increasing p-ERK nuclear shuttling and by activating c-Myc signalling upon EGF stimulation
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DOI: 10.1038/s41388-021-01736-2
Abstract: LIM kinase 1 (LIMK1) is a serine/threonine and tyrosine kinase that is predominantly located in the cytoplasm. In our study, nuclear translocation of LIMK1 in clinical hepatocellular carcinoma (HCC) samples was demonstrated for the first… read more here.
Keywords: hcc; nuclear translocation; nuclear limk1; limk1 ... See more keywords
Involvement of LIMK1/2 in actin assembly during mouse embryo development
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DOI: 10.1080/15384101.2018.1482138
Abstract: ABSTRACT LIMKs (LIMK1 and LIMK2) are serine/threonine protein kinases that involve in various cellular activities such as cell migration, morphogenesis and cytokinesis. However, its roles during mammalian early embryo development are still unclear. In the… read more here.
Keywords: actin; embryo development; limk1; limk1 activity ... See more keywords
Overexpression of LIMK1 in hippocampal excitatory neurons improves synaptic plasticity and social recognition memory in APP/PS1 mice
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DOI: 10.1186/s13041-021-00833-3
Abstract: Accumulating evidence indicates that the actin regulator cofilin is overactivated in Alzheimer’s Disease (AD), but whether this abnormality contributes to synaptic and cognitive impairments in AD is unclear. In addition, the brain region and cell… read more here.
Keywords: excitatory neurons; hippocampal excitatory; mice; limk1 ... See more keywords