Comparative Analysis of Small-Molecule LIMK1/2 Inhibitors: Chemical Synthesis, Biochemistry, and Cellular Activity
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DOI: 10.1021/acs.jmedchem.2c00751
Abstract: LIM domain kinases 1 and 2 (LIMK1 and LIMK2) regulate actin dynamics and subsequently key cellular functions such as proliferation and migration. LIMK1 and LIMK2 phosphorylate and inactivate cofilin leading to increased actin polymerization. As… read more here.
Keywords: comparative analysis; small molecule; analysis small; limk1 inhibitors ... See more keywords