Nilotinib Deregulates Cell Cycle Checkpoints, ABC Transporters Genes and JAK-STAT Signaling Pathway of CD34+/Lin- Cells in Chronic-Phase Chronic Myeloid Leukemia (CP-CML) Patients after 12 Months of Treatment
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DOI: 10.1182/blood-2018-99-112188
Abstract: Introduction Chronic myeloid leukemia (CML) is a stem cell disease characterized by the constitutive activity of the oncoprotein BCR-ABL that activates multiple signal transduction pathways. Tyrosine-kinase inhibitor (TKI) nilotinib successfully inhibits the activation and the… read more here.
Keywords: cd34 lin; lin cells; membership entity; months nilotinib ... See more keywords
Cholesterol and lipid-associated transcriptional signature in chronic myeloid leukemia patients with nilotinib-induced hypercholesterolemia
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DOI: 10.1182/blood-2025-6768
Abstract: The efficacy of nilotinib in patients with newly diagnosed Chronic Myeloid Leukemia (CML) has been extensively demonstrated in clinical trials (Sacha et al., Future Oncol. 2019). Although nilotinib provides superior overall survival and deeper molecular… read more here.
Keywords: treatment; cd34 lin; lin; lin cells ... See more keywords
Safety and Feasibility of Lin- Cells Administration to ALS Patients: A Novel View on Humoral Factors and miRNA Profiles
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DOI: 10.3390/ijms19051312
Abstract: Therapeutic options for amyotrophic lateral sclerosis (ALS) are still limited. Great hopes, however, are placed in growth factors that show neuroprotective abilities (e.g., nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), and vascular endothelial growth… read more here.
Keywords: als patients; lin cells; csf plasma; cells administration ... See more keywords