Articles with "lin28" as a keyword



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LncRNA HOTAIR Promotes LPS-Induced Inflammation and Apoptosis of Cardiomyocytes via Lin28-Mediated PDCD4 Stability.

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Published in 2021 at "Inflammation"

DOI: 10.1007/s10753-021-01431-0

Abstract: Sepsis is one of the primary causes of death in intensive care units. Recently, increasing evidence has identified lncRNA HOTAIR is involved in septic cardiomyopathy. However, the potential mechanism underlying HOTAIR on septic cardiomyopathy is… read more here.

Keywords: lps induced; pdcd4; apoptosis; hotair ... See more keywords
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The heterochronic gene Lin28 regulates amphibian metamorphosis through disturbance of thyroid hormone function.

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Published in 2017 at "Developmental biology"

DOI: 10.1016/j.ydbio.2017.03.026

Abstract: Metamorphosis is a classic example of developmental transition, which involves important morphological and physiological changes that prepare the organism for the adult life. It has been very well established that amphibian metamorphosis is mainly controlled… read more here.

Keywords: amphibian metamorphosis; lin28; metamorphosis; thyroid hormone ... See more keywords
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Molecular Dynamics Simulations for Deciphering the Structural Basis of Recognition of Pre-let-7 miRNAs by LIN28.

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Published in 2017 at "Biochemistry"

DOI: 10.1021/acs.biochem.6b00837

Abstract: LIN28 protein inhibits biogenesis of miRNAs belonging to the let-7 family by binding to precursor forms of miRNAs. Overexpression of LIN28 and low levels of let-7 miRNAs are associated with several forms of cancer cells.… read more here.

Keywords: let mirnas; molecular dynamics; pre let; recognition ... See more keywords
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Trisubstituted Pyrrolinones as Small-Molecule Inhibitors Disrupting the Protein–RNA Interaction of LIN28 and Let-7

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Published in 2021 at "ACS Medicinal Chemistry Letters"

DOI: 10.1021/acsmedchemlett.0c00546

Abstract: Modulation of protein–RNA interaction (PRI) using small molecules is a promising strategy to develop therapeutics. LIN28 is an RNA-binding protein that blocks the maturation of the tumor suppressor let-7 microRNAs. Herein, we performed a fluorescence… read more here.

Keywords: protein; rna interaction; lin28; interaction ... See more keywords
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RNA-binding protein complex LIN28/MSI2 enhances cancer stem cell-like properties by modulating Hippo-YAP1 signaling and independently of Let-7

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Published in 2022 at "Oncogene"

DOI: 10.1038/s41388-022-02198-w

Abstract: The RNA binding protein LIN28 directly modulates the stability and translation of target mRNAs independently of Let-7; however, the key downstream targets of LIN28 in this process are largely unknown. Here, we revealed that Hippo… read more here.

Keywords: rna binding; binding protein; like properties; yap1 ... See more keywords
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ETMR-18. TARGETING Lin28 IN ETMR WITH ODC1 INHIBITOR DFMO

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Published in 2020 at "Neuro-Oncology"

DOI: 10.1093/neuonc/noaa222.221

Abstract: Abstract Embryonal tumor with multilayered rosettes (ETMR), is an aggressive brain tumor primarily occurring in young patients ( read more here.

Keywords: etmr; odc1 inhibitor; dfmo; lin28 ... See more keywords
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Lin28 promoting the protective effect of PMSCs on hepatic ischaemia–reperfusion injury by regulating glucose metabolism

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Published in 2023 at "Journal of Cellular and Molecular Medicine"

DOI: 10.1111/jcmm.17739

Abstract: Human placental mesenchymal stem cells (PMSCs) can prevent liver ischaemia–reperfusion injury (LIRI). However, their therapeutic effects are limited. Therefore, additional research is required to elucidate the mechanisms of PMSC‐mediated LIRI prevention and enhance the related… read more here.

Keywords: pmscs; lin28; glucose metabolism; ischaemia reperfusion ... See more keywords
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Lin28 Regulates Cancer Cell Stemness for Tumour Progression

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Published in 2022 at "Cancers"

DOI: 10.3390/cancers14194640

Abstract: Simple Summary Cancer stem cells (CSCs) are a small population of tumour cells bearing stemness characteristics. They have been deemed as a root of cancer development and a promising drug target for anticancer therapy. Herein,… read more here.

Keywords: tumour progression; lin28; cancer; cancer cell ... See more keywords
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Trophectoderm-Specific Knockdown of LIN28 Decreases Expression of Genes Necessary for Cell Proliferation and Reduces Elongation of Sheep Conceptus

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Published in 2020 at "International Journal of Molecular Sciences"

DOI: 10.3390/ijms21072549

Abstract: LIN28 inhibits let-7 miRNA maturation which prevents cell differentiation and promotes proliferation. We hypothesized that the LIN28-let-7 axis regulates proliferation-associated genes in sheep trophectoderm in vivo. Day 9-hatched sheep blastocysts were incubated with lentiviral particles… read more here.

Keywords: elongation; proliferation; lin28; sheep conceptus ... See more keywords