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Published in 2021 at "Inflammation"
DOI: 10.1007/s10753-021-01431-0
Abstract: Sepsis is one of the primary causes of death in intensive care units. Recently, increasing evidence has identified lncRNA HOTAIR is involved in septic cardiomyopathy. However, the potential mechanism underlying HOTAIR on septic cardiomyopathy is…
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Keywords:
lps induced;
pdcd4;
apoptosis;
hotair ... See more keywords
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Published in 2017 at "Developmental biology"
DOI: 10.1016/j.ydbio.2017.03.026
Abstract: Metamorphosis is a classic example of developmental transition, which involves important morphological and physiological changes that prepare the organism for the adult life. It has been very well established that amphibian metamorphosis is mainly controlled…
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Keywords:
amphibian metamorphosis;
lin28;
metamorphosis;
thyroid hormone ... See more keywords
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Published in 2017 at "Biochemistry"
DOI: 10.1021/acs.biochem.6b00837
Abstract: LIN28 protein inhibits biogenesis of miRNAs belonging to the let-7 family by binding to precursor forms of miRNAs. Overexpression of LIN28 and low levels of let-7 miRNAs are associated with several forms of cancer cells.…
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Keywords:
let mirnas;
molecular dynamics;
pre let;
recognition ... See more keywords
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Published in 2021 at "ACS Medicinal Chemistry Letters"
DOI: 10.1021/acsmedchemlett.0c00546
Abstract: Modulation of protein–RNA interaction (PRI) using small molecules is a promising strategy to develop therapeutics. LIN28 is an RNA-binding protein that blocks the maturation of the tumor suppressor let-7 microRNAs. Herein, we performed a fluorescence…
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Keywords:
protein;
rna interaction;
lin28;
interaction ... See more keywords
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Published in 2022 at "Oncogene"
DOI: 10.1038/s41388-022-02198-w
Abstract: The RNA binding protein LIN28 directly modulates the stability and translation of target mRNAs independently of Let-7; however, the key downstream targets of LIN28 in this process are largely unknown. Here, we revealed that Hippo…
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Keywords:
rna binding;
binding protein;
like properties;
yap1 ... See more keywords
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Published in 2020 at "Neuro-Oncology"
DOI: 10.1093/neuonc/noaa222.221
Abstract: Abstract Embryonal tumor with multilayered rosettes (ETMR), is an aggressive brain tumor primarily occurring in young patients (
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Keywords:
etmr;
odc1 inhibitor;
dfmo;
lin28 ... See more keywords
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Published in 2023 at "Journal of Cellular and Molecular Medicine"
DOI: 10.1111/jcmm.17739
Abstract: Human placental mesenchymal stem cells (PMSCs) can prevent liver ischaemia–reperfusion injury (LIRI). However, their therapeutic effects are limited. Therefore, additional research is required to elucidate the mechanisms of PMSC‐mediated LIRI prevention and enhance the related…
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Keywords:
pmscs;
lin28;
glucose metabolism;
ischaemia reperfusion ... See more keywords
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Published in 2022 at "Cancers"
DOI: 10.3390/cancers14194640
Abstract: Simple Summary Cancer stem cells (CSCs) are a small population of tumour cells bearing stemness characteristics. They have been deemed as a root of cancer development and a promising drug target for anticancer therapy. Herein,…
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Keywords:
tumour progression;
lin28;
cancer;
cancer cell ... See more keywords
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Published in 2020 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms21072549
Abstract: LIN28 inhibits let-7 miRNA maturation which prevents cell differentiation and promotes proliferation. We hypothesized that the LIN28-let-7 axis regulates proliferation-associated genes in sheep trophectoderm in vivo. Day 9-hatched sheep blastocysts were incubated with lentiviral particles…
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Keywords:
elongation;
proliferation;
lin28;
sheep conceptus ... See more keywords