Lin28a protects against diabetic cardiomyopathy through Mst1 inhibition
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.29321
Abstract: Lin28a has been found to enhance glucose uptake and insulin sensitivity. Lin28a alleviates cardiac dysfunction under various pathological conditions. However, the effects and underlying mechanisms of Lin28a on diabetic cardiomyopathy (DCM) are not well‐understood. The… read more here.
Keywords: mst1; mst1 inhibition; high glucose; lin28a ... See more keywords
Interactome analysis illustrates diverse gene regulatory processes associated with LIN28A in human iPS cell-derived neural progenitor cells
Sign Up to like & getrecommendations! Published in 2021 at "iScience"
DOI: 10.1016/j.isci.2021.103321
Abstract: Summary A single protein can be multifaceted depending on the cellular contexts and interacting molecules. LIN28A is an RNA-binding protein that governs developmental timing, cellular proliferation, differentiation, stem cell pluripotency, and metabolism. In addition to… read more here.
Keywords: neural progenitor; progenitor cells; gene regulatory; lin28a ... See more keywords
Overexpression of Lin28a induces a primary ovarian insufficiency phenotype via facilitation of primordial follicle activation in mice
Sign Up to like & getrecommendations! Published in 2022 at "Molecular and Cellular Endocrinology"
DOI: 10.1016/j.mce.2021.111460
Abstract: Lin28a is an RNA binding protein and increasing evidence has indicated its role in regulating female fertility. Lin28a has been reported to be involved in ovarian follicle activation. However, its role and mechanisms in regulating… read more here.
Keywords: follicle activation; lin28a; mice; activation ... See more keywords
Lin28a up‐regulation is associated with the formation of restenosis via promoting proliferation and migration of vascular smooth muscle cells
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Cellular and Molecular Medicine"
DOI: 10.1111/jcmm.15506
Abstract: To explore the potential role of Lin28a in the development of restenosis after percutaneous transluminal angioplasty, double‐balloon injury surgery and mono‐balloon injury surgery were used to establish restenosis and atherosclerosis models, respectively, so as to… read more here.
Keywords: proliferation migration; lin28a; restenosis; smooth muscle ... See more keywords
SAT0044 Lin28a is overexpressed in osteoarthritis and is essential for the stability and high level expression of il-6 and cox-2 in human chondrocytes
Sign Up to like & getrecommendations! Published in 2018 at "Annals of the Rheumatic Diseases"
DOI: 10.1136/annrheumdis-2018-eular.6011
Abstract: Background Osteoarthritis (OA), the most common type of joint disease, is characterised by progressive and irreversible degradation of articular cartilage. Dysregulated gene expression has also been linked to disease pathogenesis. Lin28A is an evolutionarily conserved… read more here.
Keywords: human chondrocytes; lin28a; cox; expression ... See more keywords
Hypothalamic Ventromedial Lin28a Enhances Glucose Metabolism in Diet-Induced Obesity
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DOI: 10.2337/db16-1558
Abstract: The Lin28a/Let-7 axis has been studied in peripheral tissues for its role in metabolism regulation. However, its central function remains unclear. Here we found that Lin28a is highly expressed in the hypothalamus compared with peripheral… read more here.
Keywords: metabolism; diet induced; lin28a; mice ... See more keywords
Blockade on Lin28a Prevents Cognitive Impairment and Disruption of the Blood-Brain Barrier Induced by Chronic Cerebral Hypoperfusion
Sign Up to like & getrecommendations! Published in 2022 at "Biomedicines"
DOI: 10.3390/biomedicines10040852
Abstract: Lin28a is an RNA-binding protein involved in the translation and regulation of multiple mRNAs. Lin28a is overexpressed in animal models of brain injury. Similarly, our preliminary study found increased Lin28a expression levels in the animal… read more here.
Keywords: lin28a; chronic cerebral; brain; cognitive impairment ... See more keywords