DPP‐4 inhibitor linagliptin ameliorates imiquimod‐induced psoriasis‐like skin alterations in type 2 diabetic mice by inhibiting the MAPK/NF‐κB inflammatory pathway
Sign Up to like & getrecommendations! Published in 2022 at "Drug Development Research"
DOI: 10.1002/ddr.21966
Abstract: Studies have shown that the DPP‐4 inhibitor was effective in improving skin damage in patients with psoriasis, but the exact mechanism was not known. To investigate the therapeutic effects of linagliptin in mice with type… read more here.
Keywords: mapk inflammatory; dpp inhibitor; group; psoriasis ... See more keywords
Linagliptin attenuates chronic post‐ischemia pain: Possible anti‐inflammatory and anti‐oxidant mechanisms
Sign Up to like & getrecommendations! Published in 2018 at "European Journal of Pharmacology"
DOI: 10.1016/j.ejphar.2018.03.039
Abstract: ABSTRACT Complex regional pain syndrome (CRPS) is a debilitating neurologic disorder with an interlinked and yet incompletely defined pathogenesis. Treatment options remain a therapeutic challenge. Linagliptin is one of the dipeptidyl peptidase‐4 (DPP‐4) inhibitors which… read more here.
Keywords: inflammatory; linagliptin; post ischemia; pain ... See more keywords
Linagliptin mitigates experimental inflammatory bowel disease in rats by targeting inflammatory and redox signaling.
Sign Up to like & getrecommendations! Published in 2021 at "Life sciences"
DOI: 10.1016/j.lfs.2021.119295
Abstract: AIMS Dipeptidyl peptidase-4 (DPP-4) has been involved in the pathogenesis of inflammatory bowel diseases (IBD), yet the underlying mechanisms remain inconclusive. The present study aimed to investigate the potential of linagliptin, a potent/selective DPP-4 inhibitor… read more here.
Keywords: inflammatory bowel; jak2 stat3; linagliptin; hmgb1 ... See more keywords
Anti-steatotic linagliptin pleiotropic effects encompasses suppression of de novo lipogenesis and ER stress in high-fat-fed mice
Sign Up to like & getrecommendations! Published in 2020 at "Molecular and Cellular Endocrinology"
DOI: 10.1016/j.mce.2020.110804
Abstract: AIM To investigate the effects of linagliptin treatment on hepatic energy metabolism and ER stress in high-fat-fed C57BL/6 mice. METHODS Forty male C57BL/6 mice, three months of age, received a control diet (C, 10% of… read more here.
Keywords: fat fed; group; high fat; linagliptin ... See more keywords
Linagliptin, a DPP-4 inhibitor, ameliorates Aβ (1−42) peptides induced neurodegeneration and brain insulin resistance (BIR) via insulin receptor substrate-1 (IRS-1) in rat model of Alzheimer's disease
Sign Up to like & getrecommendations! Published in 2021 at "Neuropharmacology"
DOI: 10.1016/j.neuropharm.2021.108662
Abstract: Alzheimer's disease (AD) is the most devastating neurodegenerative disorder, accounting over 46 million cases of dementia globally. Evidence supports that Brain Insulin Resistance (BIR) due to serine phosphorylation of Insulin Receptor Substrate-1 (IRS-1) has an… read more here.
Keywords: insulin; linagliptin; bir; insulin resistance ... See more keywords
P0110DPP4- INHIBITOR LINAGLIPTIN ACCELERATES RESOLUTION OF CRESCENT FORMATION IN A RAT MODEL OF ANTI-GBM GLOMERULONEPHRITIS
Sign Up to like & getrecommendations! Published in 2020 at "Nephrology Dialysis Transplantation"
DOI: 10.1093/ndt/gfaa142.p0110
Abstract: Crescent formation is a severe glomerular damage in the pathogenesis of different kidney diseases. However the exact pathomechanism of crescent formation is unclear up to now. In human kidney biopsies we observed high dipeptidyl peptidase… read more here.
Keywords: linagliptin; treatment; term; crescent formation ... See more keywords
Efficacy and safety of linagliptin as add‐on therapy to insulin in Chinese patients with type 2 diabetes mellitus: A randomized, double‐blind, placebo‐controlled trial
Sign Up to like & getrecommendations! Published in 2020 at "Diabetes"
DOI: 10.1111/dom.14231
Abstract: This 24‐week, double‐blind, placebo‐controlled, phase III trial evaluated the efficacy and safety of linagliptin in 206 Chinese patients with inadequately controlled (glycated haemoglobin [HbA1c] 7.5%–10.0%) type 2 diabetes mellitus (T2DM) receiving insulin (basal or premixed) ± metformin.… read more here.
Keywords: insulin; safety; linagliptin; chinese patients ... See more keywords
Preferential prescribing of linagliptin in type 2 diabetes patients in an expanded post‐marketing surveillance study in Japan
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Diabetes Investigation"
DOI: 10.1111/jdi.13012
Abstract: To evaluate linagliptin prescribing in type 2 diabetes mellitus patients with different comorbidities, an expanded Japanese post‐marketing surveillance also collected baseline data for patients initiating other glucose‐lowering drugs. read more here.
Keywords: type diabetes; linagliptin; post marketing; marketing surveillance ... See more keywords
Linagliptin ameliorated cardiac fibrosis and restored cardiomyocyte structure in diabetic mice associated with the suppression of necroptosis.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of diabetes investigation"
DOI: 10.1111/jdi.14017
Abstract: AIMS/INTRODUCTION Linagliptin is a selective dipeptidyl peptidase (DPP)-4 inhibitor capable of successfully regulating blood glucose levels. The cardiovascular protective effects of several DPP-4 inhibitors have been shown in preclinical studies; however, the detailed influence of… read more here.
Keywords: necroptosis; cardiac fibrosis; diabetic mice; mice ... See more keywords
SGLT2 Inhibitor Empagliflozin and DPP4 Inhibitor Linagliptin Reactivate Glomerular Autophagy in db/db Mice, a Model of Type 2 Diabetes
Sign Up to like & getrecommendations! Published in 2020 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms21082987
Abstract: Recent data have indicated the emerging role of glomerular autophagy in diabetic kidney disease. We aimed to assess the effect of the SGLT2 inhibitor empagliflozin, the DPP4 inhibitor linagliptin, and their combination, on glomerular autophagy… read more here.
Keywords: glomerular autophagy; inhibitor; empagliflozin; linagliptin ... See more keywords
Thermodynamic and Computational (DFT) Study of Non-Covalent Interaction Mechanisms of Charge Transfer Complex of Linagliptin with 2,3-Dichloro-5,6-dicyano-1,4-benzoquinone (DDQ) and Chloranilic acid (CHA)
Sign Up to like & getrecommendations! Published in 2022 at "Molecules"
DOI: 10.3390/molecules27196320
Abstract: This study describes the non-covalent interactions of the charge transfer complex (CT), which was responsible for the synthesis of Linagliptin (LNG) with 2,3-Dichloro-5,6-Dicyano-1,4-benzoquinone (DDQ), or with Chloranilic acid (CHA) complexes in acetonitrile (MeCN) at temperatures… read more here.
Keywords: cha; dichloro dicyano; charge transfer; non covalent ... See more keywords